trevorkoob

8 ms·

1.
by trevorkoob 3mo ago
One interesting aspect of Vitamin D that is not regularly discussed is the photo-isomerization of Vitamin D into inactive isomers in the skin. I think of it similarly to Beta-Carotene, in that consuming the "natural source" has no
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by trevorkoob 3mo ago
When I did my master's thesis on Vitamin D supplementation the conclusion was that vitamin D testing is wildly inaccurate, and we needed to have studies based on a target level - ideally one based around sub-saharan African community l
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by trevorkoob 7mo ago
You may have a point about processing, but I think by talking about "most people" you have invalidated any future points you may be trying to make. For example: "single natural ingredient" not every cow is only fed with
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by trevorkoob 1y ago
I've stopped using photos entirely due to import bugs. So much wasted time, now I just use image capture to import and organize directly. Still get errors from time to time. Apple needs to hire more quality control, their software inte
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by trevorkoob 2y ago
The hypothesis was: is it beneficial to supplement vitamin D to reach the maximum levels achieved through sun exposure year-round? Conclusion: these types of studies did not exist at the time, but the risks of doing such studies would be mi
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by trevorkoob 2y ago
Thank you for replying!
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by trevorkoob 2y ago
Curious. Could you please share your physical activity level around the time of supplementation? One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massi
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by trevorkoob 2y ago
Other than the value you are aiming for (I personally aim for the upper edge of the normal range), I agree with the immense variability in dosage, and also would like to mention imprecision in vitamin D bloodwork tests as well. Thankfully t
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by trevorkoob 2y ago
Adding on this point, in my research I found blood serum testing to be wildly imprecise. The conclusion of my study was that we should do more studies where we take regular blood level samples and adjust dosage to achieve a certain average
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by trevorkoob 2y ago
Did a masters on Vit D. Multiple overdoses of over 1 million IU have been recovered from without obvious long-term damage present in near term follow up. Out of vitamin D’s many potentially clinically positive effects some of the clearest a
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by trevorkoob 3y ago
testing lying down as we speak. Much more comfortable. The killer market for this device is business airline travel.
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by trevorkoob 3y ago
15 minutes of full-body UV exposure from the sun is estimated to provide the equivalent of 20-30,000 IU Vitamin D3. There is a definite need for studies that better determine the effective dose for D3. My research led me to the conclusion t
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by trevorkoob 4y ago
Makes sense that we have been cooking for a long time. Our intestines look as though they have evolved around an environment of cooked food, and that takes many many thousands of years
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by trevorkoob 4y ago
Distributed ledgers are not a scam, and our true best hope for anti-corruption. I would like every elected official to have all their income and spending listed on a public ledger. True accountability of representatives to those they purpor
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by trevorkoob 4y ago
Chiming in to thank you. The access to quality information on the web, specifically Ebooks, is what gives me hope for the future.
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by trevorkoob 5y ago
I tried the exact setup of this 1000+ hours person, having been excited by the concept of a monitor-less office for years. My current setup is multiple 4k monitors in pixel-doubled resolution. It is relatively easy on the eyes and not too
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by trevorkoob 6y ago
Welcome! I highly recommend the study - even though the numbers are low, the data is very interesting.
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by trevorkoob 6y ago
I didn't mention K2 because I didn't study it. I make no claim to expertise, only familiarity. Personally, I eat dark green leafy vegetables every day - one serving of kale contains 443% daily value of vitamin K and I probably co
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by trevorkoob 6y ago
It depends - ancient ancestors had a lot of different lifestyles. For example, Soranus of Ephesus reported deformations in the bones of children as early as the 100 CE. However, this is I think what you are trying to get at: One particular
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by trevorkoob 6y ago
My thesis argued that we should not be testing supplementation levels, instead we should be testing the effects of maintaining people at various serum levels of vitamin D year-round.
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by trevorkoob 6y ago
In acute hypervitaminosis D, there can be organ calcification that has to be treated. These cases are rarely reported - one case occurred when the patient ingested crystalline vitamin D - dosing themselves in the range of 1-2 million IU D
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by trevorkoob 6y ago
There are many cases of kidney disorders causing issues in vitamin D metabolism - the majority of literature examples I read involved genetic kidney disorders which would not be be caused by increased calcium absorption. I hope you are rece
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by trevorkoob 6y ago
I noted the levels needed to maximize intestinal calcium absorption because this is the best studied aspect of Vitamin D. Rickets was the main reason Vitamin D was discovered and supplemented. Vitamin D level blood testing is imprecise - I
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by trevorkoob 6y ago
I personally aim for 10,000 IU D3 daily from either sun or supplement. In normal times, living in New York, I would supplement 10,000 IU D3 from November through March, and then I would make sure to be outside 1 hour a day with at least ar
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by trevorkoob 6y ago
Yes, this was overly brief and a tilde is not enough to qualify this statement, and I should have said noon equatorial sun. My point here was meant to be about how this is essentially the daily maximum dose from UV radiation due to the isom
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by trevorkoob 6y ago
7-dehydrocholesterol is photolyzed by UV to previtamin D. There is then spontaneous isomerization between this previtamin D, vitamin D and 2 inactive isomers. As vitamin D is used by the body, and the inactive isomers remain in the skin,
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by trevorkoob 6y ago
It is certainly a different mechanism. There are inactive isomers of pre-Vitamin D (tachysterol and lumisterol) that prevent over-production of Vitamin D from continued UV exposure. I list these numbers to give a general idea of the levels
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by trevorkoob 6y ago
Curious about your source for 3000 in 15 - I have read and reported more, and would like to read your source.
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by trevorkoob 6y ago
Did my masters on Vitamin D - It is very difficult to extract CLINICALLY RELEVANT information from retrospective epidemiological studies. However, there a a few things that are clear: 1. Calcium absorption from the intestine increases with