tominous

44 ms·

151.
by tominous 11y ago
Let's cover these one by one. "Ridiculous": the whole point of the OP is that we don't have good predictive models for what treatments will be effective. We have hunches and theories but it is currently too costly to go
152.
by tominous 11y ago
You'll note I'm proposing this accelerated approach only for terminally ill volunteers, not healthy children. I haven't edited my comment. Strangely enough, we already test vaccines and other drugs on healthy volunteers.
153.
by tominous 11y ago
If you treat a terminally ill patient and they die, then you can still learn something. Maybe there was no effect at all on the target illness, e.g. the cancer spread and grew anyway. Maybe there was a large effect but the side effects were
154.
by tominous 11y ago
The authors argue for using better predictive models to screen drugs at an early stage, because too many drugs are failing at costly clinical trials. In my opinion we already know the best predictive model to use, but we choose not to use i
155.
by tominous 11y ago
The article focuses on how a high list price can deceive consumers into thinking they're getting a good deal. That's true but it's not the whole story. Sometimes a high list price is combined with custom discounts to extract
156.
by tominous 11y ago
If you know a bit about optics it's not hard to derive. The difference between correction at 6m vs infinity is 1/6 - 1/inf = 0.166.. dioptres. On top of this, one thing that surprised me was the difference in correction betwe
157.
by tominous 11y ago
I think your friend isn't as lucky as you think. The eye/brain should automatically make the focus as sharp as possible so all that you can do consciously is make it worse. Then again, if your vision isn't perfect there are t
158.
by tominous 11y ago
One symptom of cancer, especially late-stage cancer, is cachexia: unintended weight loss. It is associated with a higher risk of death and lower quality of life. [1] In addition, cancer treatments like surgery, chemotherapy and radiation af
159.
by tominous 11y ago
Oh absolutely. That's why I've tried to make that decision ahead of time and plan the details so that it's almost an automatic trigger, hopefully before all insight is lost. It's hard because I'm a very independent,
160.
by tominous 11y ago
This story struck a nerve because (in hindsight) I saw the same thing happening to my brother when he was about 19. He was suddenly interested in astrology, reiki, "tachyon energy disks", epiphanies, angels and demons, the vibrati
161.
by tominous 11y ago
That's true but not particularly relevant to database performance. As I mentioned, random reads on an SSD do not suffer from a head seek penalty so it doesn't matter how the blocks are allocated. On the other hand with spinning di
162.
by tominous 11y ago
It's also tricky with a COW filesystem like ZFS in which the order of data on-disk may not match the logical order of the file. So your database may decide to dispatch a bunch of sequential 1MB reads to the filesystem, only for the fil
163.
by tominous 11y ago
One way to approach an announcement like this is to wait until everything is wrapped up nicely in a neat paper. Another approach is to investigate further using the tools available: look up the authors' past work on Google Scholar, che
164.
by tominous 11y ago
Thanks, I certainly have my eyes peeled for news about metastatic ACUP (or any related diagnoses) but as far as I'm aware there's no silver bullet anywhere yet. Right now the strategy is to kick the can down the road until there i
165.
by tominous 11y ago
From a sociology point of view, yes you should distrust any signs of p-hacking or selective reporting, especially when there is a low effect size. From a technology point of view, I think we are already well past "no one.. really knowi
166.
by tominous 11y ago
I'm biased. My wife was diagnosed with metastatic cancer 6 months ago. With current standard treatments there is a 3-year survival rate of practically zero, so to me the most important thing is getting new effective treatments develope
167.
by tominous 11y ago
I came here to make the same comment. Overlaying the images with crossed eyes, you can easily see that snails A and C share the most similar pixels. The mistake is in Figure 1 of the original paper and has been copied to the article.