stultissimus

5 ms·

1.
by stultissimus 8mo ago
PDX is a double edged sword. Human tumors are engrafted into mice with no immune system. Immune-cancer interface is incredibly important, yet completely lacking in these models. Consider that some of the greatest cancer drugs ever work spec
2.
by stultissimus 3y ago
Reading life science textbooks and substacks is a great way to get started (see [1], [2]). Also, there is a major deficit of software engineering talent in biology research (probably because pro SWEs are too expensive for academic labs, and
3.
by stultissimus 3y ago
This has actually been done for genetic circuits in E coli (bacteria) by Chris Voight's lab at MIT. Their platform is called Cello [1], and it enables interoperation between Verilog/HDL and genetic code. This kind of thing has not
4.
by stultissimus 3y ago
Synthetic biologist here. This is a good answer, but looking at man-made genetic programs can give us a simplified perspective. We've made significant progress engineering programs that enable human T cells to kill target (cancer) cell
5.
by stultissimus 4y ago
> If you don't mind me asking, how do you deal with this kind of culture, where a normal process is being purposefully obstructed with such behavior from the reviewer? A huge part of the explanation is survivor bias IMO. The vast ma
6.
by stultissimus 4y ago
In general we can conduct 'directed evolution' (selective breeding is an example). In this example, however, we're talking about improving the resistance of Halderia to the possible future mutations the viruses could develop
7.
by stultissimus 4y ago
Mutation rate ranges many orders of magnitude. See a figure here (linking a tweet (not mine) to avoid journal paywall, but underlying paper is linked in the tweet): https://twitter.com/DrCJ_Houldcroft/status/152724
8.
by stultissimus 4y ago
> 1. the parent raised questions in a neutral way. these questions seem essential for validating experimental design. why would peer reviewers present such questions in passive-aggressive ways, and how can we fix this? Peer review is obv
9.
by stultissimus 4y ago
Biophysicist here. Excellent questions – these are the kind of points peer reviewers would raise (though typically in far more esoteric and passive aggressive ways...). (1) could be addressed in experiments where the algae-consumers in ques
10.
How AI found the words to kill cancer cells(phys.org)
3 points by stultissimus 4y ago|0 comments