sradman

71 ms·

271.
by sradman 6y ago
We are talking about two alternative architectures, Cloudflare Workers and Fastly Compute@Edge, solving the same problem: how to run server-side untrusted code. Cloudflare runs a sandboxed V8 runtime in-process with its Nginx servers while
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by sradman 6y ago
Good question. The article says: > These drugs face the challenges of targeting mRNA to specific tissues and giving strong, lasting benefits without excessive side effects. This innovation reminds me of Virginia Postrel's book The
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by sradman 6y ago
They use CRISPR/Cas9 [1] techniques on animal models, mice in this case. They knock out the gene that transcribes the protein in question and observe the impact in the lab. [1] https://en.wikipedia.org/wiki/CRISPR
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by sradman 6y ago
From the paper Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis [1]: > Regulation of glial activation and neuroinflammation are critical factors in t
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by sradman 6y ago
The Olkiluoto Nuclear Power Plant [1] is located on an island off the west coast of Finland. A problem was identified during an inspection on Dec 10th: > When the pump of the cooling system was stopped, one of the valves was broken. For
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by sradman 6y ago
Since I have your ear, in hindsight do you think the promotion of IndexedDB over SQLite/WebSQL was a good move? I think persistent SQLite is on the verge of returning to the browser via WebAssembly but it needs a proper POSIX-like WASI
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by sradman 6y ago
> A mystery to discuss another time. The article discusses four strategies and I think your (assuming you are the Brendan Eich) strategy for Brave falls under 3. Technological pessimism, though it needs a better name. You are correct,
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by sradman 6y ago
The following *PCR Vs Rapid Antigen" 7min YouTube video [1] is the best summary of the Michael Mina $Dollar-a-Day-Lick-a-Stick strategy that I've come across. I find it fascinating how this seemingly simple idea has been received.
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by sradman 6y ago
And that Eich went on to create the privacy focused Brave browser based on Chromium. Yet, these mistakes didn’t really change the downward trajectory. Apple and Google are the dominant mobile platforms and I can’t see how an independent des
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by sradman 6y ago
The article is based on the book A Libertarian Walks Into a Bear: The Utopian Plot to Liberate an American Town (And Some Bears) by Matthew Hongoltz-Hetling [1]: > A Libertarian Walks Into a Bear is the sometimes funny, sometimes ter
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by sradman 6y ago
> The often-outspoken Jack Ma, Alibaba's founder, recently paid a high price for another public jab at regulators. Days after Ma likened traditional banks to pawnshops and labeled the existing financial regulatory framework an &quot
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by sradman 6y ago
The paper A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon [1]: > In U.S. Pacific Northwest coho salmon (Oncorhynchus kisutch), stormwater exposure annually causes unexplained acute mortality when adult
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by sradman 6y ago
> I think this move was a mistake. They've thrown away the benefits of a incredible wiki-based platform Ideally, you want to cater to both the CLI centric workflows of developers/build-systems and the WebUI centric workflows of
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by sradman 6y ago
> it has literally no purpose beyond mining peoples' data Its main purpose is targeted ads while repurposing or reselling peoples’ data is a nefarious secondary use. Multi-sided markets are important revenue models that are tailored
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by sradman 6y ago
The API is good for general purpose book metadata. I found the Goodreads database a good source for series order; maybe I just didn’t look very hard.
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by sradman 6y ago
https://www.goodreads.com/api
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by sradman 6y ago
Exactly, very cool but unsurprising. The Wikipedia article starts: > Beaked whales are a group of cetaceans noted as being one of the least known groups of mammals because of their deep-sea habitat and apparent low abundance. Only three
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by sradman 6y ago
TL;DR: Eight years of sun arcs were captured using long exposure solargraphy [1] at a teaching observatory near London. The pinhole camera was forgotten and left out longer than the typical 6-12 months. [1] https://en.wikipedia.o
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by sradman 6y ago
Spatial audio comes from 5.1 surround sound and I am guessing that the sound source aware orientation comes from Ultra Wideband. I don’t know if Bluetooth has a profile that supports surround sound. Maybe the spatial audio only works on dev
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by sradman 6y ago
And macOS Catalina deprecated 32-bit apps which set the stage for a pure 64-but Rosetta 2 emulator for the M1. The 32-bit deprecation makes more sense now.
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by sradman 6y ago
From the article: > In early November, Bloomberg first reported that Hyundai was in talks to acquire Boston Dynamics from Tokyo-based SoftBank Group. The Japanese conglomerate is selling off non-core business assets after it was hit hard
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by sradman 6y ago
2018 study Energy compensation in response to aerobic exercise training in overweight adults [1] and 2020 study Incentive sensitization for exercise reinforcement to increase exercise behaviors [2]. My key takeaway is that we consume up
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by sradman 6y ago
Or a wiki page [1]. The question then turns to what value the long form book adds. I think one aspect is that consuming content over multiple days approximates the first few cycles of a Spaced Repetition system [2]. [1] https://e
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by sradman 6y ago
> $549!? ...I don't understand why you would buy these when there are a lot of established professional audio companies offering better sound at a cheaper price. In addition to brand trust which other commenters describe, there is m
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by sradman 6y ago
The pdf Jean-Louis Gassée links to in the 2nd paragraph is an excellent source for the evolution of Apple silicon up until the A12X: > An Hungarian researcher by the name of Dezsö Sima offers an exhaustive history of Apple processors [1]
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by sradman 6y ago
OAuth 2.0 PKCE (pronounced "pixy") [1] is described in RFC 7636: Proof Key for Code Exchange by OAuth Public Clients [2]: > OAuth 2.0 public clients utilizing the Authorization Code Grant are susceptible to the authorization
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by sradman 6y ago
> Of 23 activities of daily life that the survey asked about, there were only three that the majority of respondents had done in the last month: gathering outdoors with friends; bringing in mail without precautions; and running errands,
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by sradman 6y ago
There are many ways to skin a cat. Some considerations: 1. Random value vs. string Hash (e.g. git SHA-1) 2. If Hash, string(s) and/or Salt used for the Hash 3. Fixed Length Key vs. Variable Length URLs/IDs 4. DB Storage: INTEGER,
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by sradman 6y ago
Several Big Tech vendors are designing ARM SoCs as outlined in the recent HN post The Tech Monopolies Go Vertical [1]. The Snapdragon 888 seems to compete with the Apple A14. I wonder why there isn’t more comparisons between the A14 iPad
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by sradman 6y ago
Netscape had LiveWire, Microsoft had ASP, and Sybase had PowerDynamo. The first version of ASP was interpreted and supported pluggable scripting engines including JScript and VBScript. The Netscape and Sybase DynaScript interpreters ran on

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