searine

26 ms·

301.
by searine 8y ago
As a volt owner, I agree. I love this car to death, especially because I'm not in a living situation that would make at-home EV charging easy (apartment). PHEVs are perfect. I drive EV 80% of the time but still have all the convenience
302.
by searine 8y ago
>Zalgo comic edits started on SomethingAwful Everything started on SomethingAwful many many years ago.
303.
by searine 8y ago
I have snowboarded for 20 years. Wear a helmet. Seriously WEAR A HELMET.
304.
by searine 8y ago
I have a 2011 volt and have had negligible degradation. Thats an N of 1 but from GMs data, degradation hasn't been an issue in volts.
305.
by searine 8y ago
>but that would make it even harder to find a place to rent Maybe i wasn't clear, but my point was that when renting is the most common way of living, it is not healthy for society. Ownership promotes community and responsibility. R
306.
by searine 8y ago
That just side steps the problems, and Airbnb is just an excuse. There needs to be regulation that makes it easier for the tenant to also be the owner.
307.
by searine 8y ago
>The human genome is still not complete by any normal definition Well considering that the human genome is a moving target, it can never be "complete". However, it can be 99.9% complete, which is all but complete for all scient
308.
by searine 8y ago
23andme is casual genetics, and misses a lot of the variants that are important clinically. These ancestry sites are the entry point, but not the definitive answer. SNP chips are on the way out and whole genome/whole exome are becoming
309.
by searine 8y ago
Nobody shares your genome. Promethease though allows for gvcfs and other formats so that you can upload more comprehensive sequencing data with full coverage.
310.
by searine 8y ago
Just stupidly high coverage. Something like 200x coverage over six replicates from blood and saliva. We needed DNA for QA purposes and I happen to have DNA, dontchaknow.
311.
by searine 8y ago
Word of warning. Take promethease with a grain of salt. For example, promethease predicted a deletion in my genome (didn't actually observe a call, just inferred the deletion from linked sites) for a highly pathogenic disease in my dat
312.
by searine 8y ago
> I wonder what proportion of couples knew each other directly or indirectly before they go together: A good proportion I bet, but they didn't meet on a dating app. Dating apps are used by people trying to "catch other fish in
313.
by searine 8y ago
By kids I mean parents posting photos of kids.
314.
by searine 8y ago
> the majority of users are between 18 to 44 Yes but what kind of people? The only young people I see on facebook are married couples and kids. Not exactly the prime dating demographic.
315.
by searine 8y ago
To play devils advocate : >Dating apps live and die by their userbase so we're already doing pretty good there. The only people on facebook are boomers arguing about politics. Dating is all about exclusivity and compartmentalization
316.
by searine 8y ago
Colorizing single images will always been a bespoke task. There are just too much missing data in the image to be able to create high quality colorizations from the photo alone. However, I think the real application here is colorizing frame
317.
by searine 8y ago
Great paper by good scientists. Also, cool that they put it on biorxiv.
318.
by searine 8y ago
Thats an expensive and dirty solution to a solved problem. Many opera houses have subtitles in the backs of seats. While not as ideal as in your glasses, it is certainly more comfortable, cheaper to buy and maintain, and clean. I get that y
319.
by searine 8y ago
Yes, but the volume is higher than granular sugar. It's a "bulking agent" to give the sweetener a pleasing volume.
320.
by searine 8y ago
Exactly. Most of that white powder in a sugar packet is dextrose filler.
321.
by searine 8y ago
Mastodon : https://news.ycombinator.com/item?id=13303346
322.
by searine 8y ago
23andMe as done several dozen publication performing GWAS using the genetic data combined with questionnaire data. This type of study aims to link symptoms with genetic cause. They have actually made a pretty significant impact in genetics
323.
by searine 8y ago
Agreed. People underestimate how excruciating it is to collect large sample-sizes of genetic data. The database 23andMe has is so stupidly valuable because 1. the sequencing is already done (and paid for) and 2. They can follow up with surv
324.
by searine 8y ago
Honest question. What is a hacker going to do with my genetic data? What threat does having my medical predispositions publicly available have? Is the hacker going to call me up and suggest I start taking high blood pressure medication?
325.
by searine 8y ago
I shouldn't have brought credentials into this, its bad form on my part. But anyway, I was just relating what I've heard from colleagues and my dis-taste for the articles definitive title.
326.
by searine 8y ago
It is worth noting that these SNPs aren't causal, they are just associated. The resolution of GWAS isn't at the level yet where we can pick out individual changes that cause a phenotype. Instead we can detect that a chunk of the g
327.
by searine 8y ago
>How much would it cost to build this? It's not just cost, but also logistics, education, and adoption. In the region where bed-nets are important, you don't usually have electricity, easy access, or deep understanding of anti-
328.
by searine 8y ago
I agree. I am taking issue with the articles title "CRISPR-Cas9 gene editing causes lots of mutations" From the current literature, there have been bad and good examples of this, but it is still a field in flux. We do not know con
329.
by searine 8y ago
>Some of it is garbage This is why it is controversial.
330.
by searine 8y ago
Speaking as a biologist. Among my colleagues, it is still very controversial. It should be noted that "controversial" scientifically means something different than in the general public. What I mean is that we see and believe the

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