robwwilliams

7 ms·

61.
by robwwilliams 7mo ago
Very well done study with a cautious interpretation of potential translational relevance in humans. The paper is open access. The discussion does a fine job of providing a full context for interpreting their findings. https://www
62.
by robwwilliams 7mo ago
> We can steer our own learning corpus This is critical. We have some degree of attentional autonomy. And we have a complex tapestry of algorithms running in thalamocortical circuits that generate “Nows”. Truncation commands produce sequ
63.
by robwwilliams 7mo ago
Well worth reading from Pam Vagata. Some important insights and predictions. Her vision of autonomy is not true autonomy, but a vision of AI servants on slightly longer chains. Is that fair? Yes, I think so. The key questions are not being
64.
by robwwilliams 8mo ago
The review should have expanded on this at a practical level even mom and dad could understand—the standard “better life through chemistry” angle.
65.
by robwwilliams 8mo ago
Perfect! I read this “heart-warming” overview of two papers in Science and learned zero about why this is of any significance. The discovery is significant but I had to probe Opus 4.6 to find out why. The personal focus is a distraction. I
66.
by robwwilliams 8mo ago
Quitting their jobs? How is that the pragmatic or effective response?
67.
by robwwilliams 8mo ago
Sure you can grade “commendable” if you want, but this counts as commendable to me even if wealthy. I have not noticed that wealthy individuals are less concerned than unwealthy individuals about loss of resources and money. In fact, wealth
68.
by robwwilliams 8mo ago
All excellent points to add to the motivation to hold the line just where it has been.
69.
by robwwilliams 8mo ago
Agree: Humans are much more frightening as an existential risk than AI or AGI. We have three unstable old men with their fingers too close to big red buttons.
70.
by robwwilliams 8mo ago
This is almost too damn funny/perfect to believe. All it had to add: "And you will get some good exercise too."
71.
by robwwilliams 8mo ago
Sonnet 4.6 failed for me. “Walk. It’s 50 meters—a 30-second stroll. Driving that distance to a car wash would be slightly absurd, and you’d presumably need to drive back anyway. “ Opus 4.6 nailed it: “Drive. You’re going to a
72.
by robwwilliams 9mo ago
Somewhat different type of problem and perhaps a useful precautionary tale. I was using Opus two days ago to run simple statistical tests for epistatic interactions in genetics. I built a project folder with key papers and data for the anal
73.
by robwwilliams 9mo ago
This was my experience too over Dec 2025. Thereafter marginal Claude Pro utility. They are struggling with demand.
74.
by robwwilliams 9mo ago
Love this idea. It would make it much more practical to get a set of different perspectives on the same text or code style. Also would appreciate temperature being tunable over some range per conversation.
75.
by robwwilliams 9mo ago
Not too dissimilar to the situation of the well known neurosurgical patient Henry Molaison (H.M.) who had very limit long term memory of his childhood and young adulthood but little after surgery at 27 years of age. He retained cognitive ab
76.
by robwwilliams 10mo ago
There is at best modest support that shortened leucocyte telomeres cause differences in lifespan. Results of Mendelian randomization studies are weak and causality is uncertain. Some evidence that longer telomeres may increase cancer risk.
77.
by robwwilliams 10mo ago
The paper is concerned mainly with one of several glutamate receptor subtypes.
78.
by robwwilliams 10mo ago
That quote is over the top. Given the imbalance between groups it is also embarrassing to read.
79.
by robwwilliams 10mo ago
The reduction of mGluR5 was reported 10 years ago in postmortem tissue. doi: 10.1016/j.bbi.2015.05.009
80.
by robwwilliams 10mo ago
Classic academic public relations piece. Not bad but more fluff than insight. Authors often have to grin and bear this PR machine, praying peers will forgive them their trespasses. But here there’s a basic design flaw. This is a study of 16
81.
by robwwilliams 10mo ago
Agreed. In my opinion, too much strange embodied experience in this engaged and engaging Part 1. If I told you stories from my childhood as an 10-year old child of an undercover operative in West Germany in 1962-1963 I think many would clai
82.
by robwwilliams 10mo ago
Thanks for this context. Here is one specific link to the project by Adam Binksmith from April 2025. https://theaidigest.org/village/blog/introducing-the-agent-v... Would have been a safer experiment in a sandbox
83.
by robwwilliams 10mo ago
Please provide a breakdown. I find this 4X of base salary implausibly high. 2X strikes me as closer to my reality at a large academic medical center.
84.
by robwwilliams 10mo ago
Brilliant <ttul>! I would have needed help from Claude to tangle it up so well and on topic. But that last lucid sentence is rubbish.
85.
by robwwilliams 11mo ago
And Anthropic Claude
86.
by robwwilliams 1y ago
Only if you ask it to or let it lead you. Just say no.
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by robwwilliams 1y ago
Agreed. This short target piece is an amusing Luddite rant. No true content other than to bemoan our first stumbling steps toward using AI to write and think. I am a reasonably good (but sloppy) writer and use Claude to help improve my text
88.
by robwwilliams 1y ago
No, nothing to do withPenrose’s idea. No quantum effects just the traditional use of microtubules for transport of cargo — in this case between adjacent dendrites.
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by robwwilliams 1y ago
Could be helpful. I often edit scientific papers and grant applications. Orienting Claude on the frontend of each project works but an “Editing Skill” set could be more general and make interactions with Claude more clued in to goals instea
90.
by robwwilliams 1y ago
Yes, I share some of your concerns about groupthink and research cliques. The best and balanced critique is Karl Herrup’s book at MIT Press: “How Not To Study a Disease”. Your comment is over the top with respect to NIH-funded researchers d

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