rgejman

18 ms·

121.
by rgejman 12y ago
If they are in fact small enough to escape via biliary excretion, that would be great. But just skimming the literature it looks like they can accumulate and persist for weeks in the liver—a situation which would suggest hepatotoxicity is a
122.
by rgejman 12y ago
I am very pessimistic about the likelihood of this being a non-toxic visualization strategy in mice or men. These "microdiamonds" are unlikely to clear the kidneys, leading to kidney toxicity. This is the problem with all ≥ nanosc
123.
by rgejman 12y ago
The idea that DNA length is costly to the organism is a venerable, but increasingly controversial theory. The existence of disproportionally huge genomes belies the hypothesis. While it's possible that some organisms derive benefit fro
124.
by rgejman 12y ago
OP: I'm sure the service you offer is great. Moreover, I'm sure that not requiring any identifying information greatly improves the experience you give to first-time users and increases conversion. However, you are inevitably doin
125.
Coding fail on Silicon Valley TV Show (S01E06)(pic.twitter.com)
4 points by rgejman 12y ago|0 comments
126.
by rgejman 12y ago
Cows ought to be on that list as well. They kill 10-20 people per year in the US alone. http://tierneylab.blogs.nytimes.com/2009/07/31/dangerous-cow...
127.
by rgejman 13y ago
I think that they will incubate CD8 and CD4 T cells from the same mouse together. The CD8 (cytotoxic) T cells, if they recognize the antigen, should kill the infected CD4 cells. A caveat is activation/co-stimulation. The CD8 T cells s
128.
by rgejman 13y ago
That's an interesting approach. Re not knowing if the human analogs are immunogenic yet: An alternative way to to answer your question would be to identify a T cell receptor (TCR) clone that recognizes your peptides of interest. There
129.
by rgejman 13y ago
#1 suffers from the critique I mentioned above. The peptide(s) you are using are designed for H2d. Do you have evidence that their human analogs* are immunogenic? #2 I assume now you are using the human version of the peptide? I'm not
130.
by rgejman 13y ago
Another thing I want to point out is that your home page touts safety as a design point. The text under "SAFE" says "Our vaccine does not contain killed viruses, live viruses, or genetically-modified viruses." I STRONGLY
131.
by rgejman 13y ago
There are a lot of moving parts, so it's really hard for me to estimate the cost here. It's done somewhat routinely in some institutions (although it is very, very expensive). You first need to make humanize mice (i.e. mice with h
132.
by rgejman 13y ago
Some thoughts on this white paper, with the caveat that I'm not sure how much of what is discussed they have done and how much of it is what they are planning to do. The white paper is light on details and I re-iterate my appeal for th
133.
by rgejman 13y ago
I'm confused as to why you would encourage anyone to donate money to your organization without providing any data. I'm also confused about why you care about publication in traditional scientific mediums. You are starting a compan
134.
by rgejman 13y ago
This article is fear mongering with incomplete information. There are huge problems with the current techniques we use to introduce DNA into cell lines of all kinds (human or other mammals). For instance, the virus techniques he describes
135.
by rgejman 13y ago
Judging by her article history, she seems like more a tech columnist and not a science news writer.
136.
by rgejman 13y ago
A fundamental problem with this strategy is that is may bias the results towards prolific haters—i.e. people who are frequently hateful on Twitter. These people may live in places where social norms permit online hateful speech without repe
137.
The Dark Side of Energy Independence(nytimes.com)
2 points by rgejman 13y ago|0 comments
138.
by rgejman 13y ago
I wasn't familiar with that. Is that stress-related? Mastectomy without chemo should not induce menopause, as far as I understand the physiological processes at work. If the patients are also being treated with tamoxifen or other estrogen r
139.
by rgejman 13y ago
Just as an FYI: Women can also have some loss of sexual function, either physically (due to ligation of the 4th intercostal nerve that supplies the nipple), psychologically or both.
140.
by rgejman 14y ago
The comments about the use of percentiles biasing the data are very true, in particular because there are effectively 3 pools of patients in the US: private/employer insured, Medicare/Medicaid and uninsured. Medicare and Medicaid pay far le
141.
by rgejman 15y ago
This seems like a problem ripe for solving with a markov model.
142.
by rgejman 15y ago
Sorry, I didn't mean to propose that all of this data would be included when you download the document. A downloaded document could be as simple as a hash or a document identification # (or a magnet link :)). You open this document in a pro
143.
by rgejman 15y ago
Right, but you can provide a platform for solving these problems over time if you make publishing work off of an extensible, data-presentation separate document model. PDF isn't it. More directly to your point: I agree that the "telling a
144.
by rgejman 15y ago
This argument quickly tends towards absurdum. Even with all of the materials, equipment and original experimenters, you cannot reproduce the context of the original results. But we can do our best to ensure that we can try to reproduce the
145.
by rgejman 15y ago
A Github for scientific code doesn't go nearly far enough. The transition from paper journals to electronic publications has only converted dead-paper into "electronic" paper. With some exceptions, e.g. video recordings, animations and supp
146.
by rgejman 15y ago
Aren't boyfriends/girlfriends/spouses/partners the obvious confounders here? They don't seem to address that point, yet they observe that the "best friend" is usually of the opposite sex. That may be true, but the study seems to be making a
147.
by rgejman 15y ago
Based on anecdotal evidence from my friends and my own renting experience: Salaries: between 60 and ~100k for 0-2 years out of college (those are my friend's age ranges). Rent: Highly dependent on where you live. Assuming you want to live d
148.
by rgejman 16y ago
This is possibly the most poorly written article I have ever read on HN.
149.
by rgejman 16y ago
I wonder how these prices change over time. e.g. are tickets for travel in February cheapest if bought in July?
150.
by rgejman 16y ago
Evolution does not typically work at those timescales (100-200 generations) unless there is extreme pressure—and even if it did, your argument still would not apply unless you believe that success in moneylending and other professions were

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