reasonattlm

16 ms·

61.
by reasonattlm 9y ago
There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that yo
62.
by reasonattlm 9y ago
What sort of evidence would it take to challenge my assessment of the data to date that methods of raising NAD+ levels with age, such as nicotinamide riboside supplementation, are not worth pursuing as a major area of focus in research and
63.
by reasonattlm 9y ago
A good recent paper on sources of inflammation in aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850851/ As it points out, the most obvious and promising of current prospects for reducing inflammation i
64.
by reasonattlm 9y ago
If you are old enough to remember the hype about resveratrol and sirtuins, that eventually resolved to nothing at all of any great use for human medicine, this is basically the same people singing the same song about roughly the same area o
65.
by reasonattlm 9y ago
Most stem cell therapies produce benefits through the signaling of the transplanted cells, near all of which die off rather than integrate. This is an example of an approach that goes beyond that, providing a set of more organized cells in
66.
by reasonattlm 9y ago
Biological age, as opposed to chronological age, is driven by the intrinsic processes of primary aging, the accumulation of molecular damage outlined in the SENS rejuvenation research proposals, but also by the influence of the environment,
67.
by reasonattlm 9y ago
Underneath it all, this is a manifestation of an important split in the cryonics community. One group is (I think overly) critical of present vitrification approaches and the planned future of those approaches. They believe that these appro
68.
by reasonattlm 9y ago
An aging research community already exists that is ten times or more larger than would be needed to get to a comprehensive implementation of mouse rejuvenation after the SENS Research Foundation model in ten to twenty years. They are just l
69.
by reasonattlm 9y ago
Mildly amusing, but basically silly. There is a reason why everyone in the past failed, and that is because they didn't have sufficiently advanced biotechnology to (a) understand the causes of aging in terms of specific low-level cell
70.
by reasonattlm 9y ago
Mildly amusing, but basically silly. There is a reason why everyone in the past failed, and that is because they didn't have sufficiently advanced biotechnology to (a) understand the causes of aging in terms of specific low-level cell
71.
by reasonattlm 9y ago
Given that this study focuses on declining naive T cell production and thymic tissue loss, it is interesting to look at another recent study that suggests these losses are the dominant cause of increased cancer rates with age. https:/
72.
by reasonattlm 9y ago
Publicity materials: https://theconversation.com/exercise-can-slow-the-ageing-pro... Paper: https://doi.org/10.1111/acel.12750 This age of biotechnology is also an age of comparative indolence and comf
73.
by reasonattlm 9y ago
Well, I suppose given the success of In Silico Medicine, after many years of grit and bootstrapping, it was inevitable to see other groups try the same model and find willing sources of funding. If these folk apply their technology to disco
74.
by reasonattlm 9y ago
Entropy arguments for the primacy of aging are fairly silly. For one, there are actually species that appear to be essentially immortal. Secondly, the germline. Cellular systems are clearly capable in principle of indefinitely maintaining t
75.
by reasonattlm 9y ago
Leaving aside for a moment the issues of healthcare being wrapped up in a system of regulation and entitlement that makes a healthy marketplace impossible, and growth in demand harmful rather than beneficial. Putting that to one side, the r
76.
by reasonattlm 9y ago
No radical developments? Near all medical expense is at present due to age-related disease. When the distinct and understood causes of aging can be treated as medical conditions, which at present they are not, then that expense will be redu
77.
by reasonattlm 9y ago
It is considered to be somewhere between very technically challenging and actually impossible to significantly increase life span without making people healthier. Without fixing the underlying damage that results in raised mortality with ag
78.
by reasonattlm 9y ago
Earlier findings from the same study data led with "Childhood intelligence was inversely associated with all major causes of death": https://doi.org/10.1136/bmj.j2708 There is definitely a conversation taking
79.
by reasonattlm 9y ago
Possibly so, which is a phenomenon that might explain how stochastic nuclear mutation at its given rates can possibly cause widespread enough harm to be significant. There is an interesting recent paper on that subject: https://d
80.
by reasonattlm 9y ago
Other age-related cell and tissue damage that raises the risk of cells becoming cancerous, or reduces the effectiveness of internal-to-the-cell controls that can shut down and destroy cancerous cells, would be the other variable, I'd i
81.
by reasonattlm 9y ago
Mice raised in a germ-free environment have improved health measures and longer average life span: http://dx.doi.org/10.1016/j.chom.2017.03.002 Not all pathogens are equal; cytomegalovirus may be far more important tha
82.
by reasonattlm 9y ago
Paper: https://doi.org/10.1073/pnas.1714478115 Which is a suggestive model, by the way, not direct evidence. The best direct evidence would be to restore the pace of immune cell creation - such as via regeneration of t
83.
by reasonattlm 9y ago
https://en.wikipedia.org/wiki/Immunosurveillance "Cancer immunosurveillance is a process by which an organism's immune system recognizes transformed cells in order to inhibit the growth of neoplastic tissue.
84.
by reasonattlm 9y ago
Original publicity materials: https://med.stanford.edu/news/all-news/2018/01/cancer-vaccin... Paper: https://doi.org/10.1126/scitranslmed.aan4488
85.
by reasonattlm 9y ago
No. Here are some views on aging that capture present thinking on the topic. https://doi.org/10.18632/aging.100640 "Why do humans live longer than other higher primates? Why do women live longer than men? What is
86.
by reasonattlm 9y ago
Some other items worth considering in the context of why mortality rates look the way they do: https://doi.org/10.1006/jtbi.2001.2430 "Reliability theory is a general theory about systems failure. It allows resear
87.
by reasonattlm 9y ago
http://dx.doi.org/10.1089/rej.2014.1636 "Can memory be retained after cryopreservation? Our research has attempted to answer this long-standing question by using the nematode worm Caenorhabditis elegans, a well-kn
88.
by reasonattlm 9y ago
You also were born in the past. Are you not comfortable with death by your own declaration? So why do you work to avoid it, rather than embracing it? Why are you still alive? Are you not, by your own ethics, outside your time, creating a me
89.
by reasonattlm 9y ago
Reversible vitrification of organs is a field starting to show some promise. It will revolutionize the transplant industry, and will bring more attention to cryonics. https://www.economist.com/news/science-and-technolog
90.
by reasonattlm 9y ago
Aging research as a whole is miserably underfunded. Perhaps $3-5B/year at most, if you take the NIA budget and then make some sketchy multiplications based on studies of public/private research expenditure and US/rest of worl

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