reasonattlm

11 ms·

31.
by reasonattlm 8y ago
Calorie restriction is probably the most important aspect of short term fasting of the sort achieved by eating only in some parts of the day. Animal studies show that isocaloric intermittent fasting, altering eating schedules, to e.g. alter
32.
by reasonattlm 8y ago
Autopsies of supercentenarians suggest that transthyretin amyloidosis and consequent heart failure is the limiting process. Since methods of removing transthyretin amyloid are somewhere in the pipeline (Covalent Bioscience, Pentraxin Therap
33.
by reasonattlm 8y ago
This is why one has to read papers in context. You can't just read a paper: you have to then go off and read some reviews that cover the surrounding science. Then read some other papers on the topic of interest. Pay attention to dates
34.
by reasonattlm 8y ago
Not all of the benefits. There are some significant benefits to the immune system that require at least 72 hours of fasting in humans. https://www.fightaging.org/archives/2014/06/fasting-can-be-u...
35.
by reasonattlm 8y ago
Microbial theories of Alzheimer's don't change the amyloid cascade hypothesis picture - that the disease begins with high levels of amyloid aggregates, then proceeds to high levels of tau aggregates enabled by the amyloid, and it
36.
by reasonattlm 8y ago
Arguably one dose per year. Arguably several in close sequence, but still very intermittently, such as once a year. Senescent cells accumulate slowly, so there is no reason to dose frequently on an ongoing basis. Different mouse studies of
37.
by reasonattlm 8y ago
Want to help the elderly? Then help with the logistics needed to get current first generation well-characterized senolytic drugs into widespread use. The failing health of the elderly is the root of every challenge related to old age, and t
38.
by reasonattlm 8y ago
The present rate of increase of life expectancy at birth is 1 year every 5 years. The rate of increase of life expectancy at 65 is 1 year every 10 years. These are highly artificial measures, a metric of what will happen if technological pr
39.
by reasonattlm 8y ago
Oxidative stress and inflammation go hand in hand. Aging has rising levels of both. Mitochondrially targeted antioxidants such as SkQ1 were first approved for use against inflammatory eye conditions. They act to dampen the consequences &#x2
40.
by reasonattlm 8y ago
No, this really is breaking the mice, not inducing something that looks like SENS-relevant damage in mitochondria. The details matter. Many means of breaking cell biology can produce things that look superficially like accelerated aging in
41.
by reasonattlm 8y ago
In the case of infectious disease, clearly your scenario isn't what happens in the real world. Otherwise no disease could be cured. In the case of aging, everyone ages for the same reasons. A few types of underlying molecular damage th
42.
by reasonattlm 8y ago
It is quite possible to succeed and still fail your trial. Which is one of the many reasons these things should be thrown out in favor of patient choice. You could spend 1/10 of the cost of later trials on publishing risk assessments a
43.
by reasonattlm 8y ago
If you run through the ~15 years of my blog, Fight Aging!, you'll find scores of promising lines of work that never made it much further than the initial reports. Medical science has a huge chasm of death between research and commercia
44.
by reasonattlm 8y ago
Quercetin on its own is not significantly senolytic. Only in combination with dasatinib. See: https://doi.org/10.1371/journal.pone.0190374 Another argument against quercetin on its own having any significant effect is
45.
by reasonattlm 8y ago
Senescence is a tool of embryonic development repurposed to wound healing and cancer suppression. Cells need to be suppressed once the finger is done being built at the end and the edges, and senescent cells do that job. Cancerous tissue ne
46.
by reasonattlm 8y ago
The paper: https://doi.org/10.1038/s41591-018-0092-9 The usual sources for bypassing journal paywalls will work. The lifespan curves in the paper are very nice: same slope, shifted to the right all the way down to 100%
47.
by reasonattlm 8y ago
One would have to speculate; it is very unclear. Proficient regeneration seems like it would be a good thing to pair with restoration of stem cell function, but without the restoration of stem cell function it might not be too helpful. As a
48.
by reasonattlm 8y ago
In terms of gaining knowledge about the most relevant mechanisms in proficient regeneration, ARF seems important, and human ARF can shut down zebrafish regeneration [1]. That implicates the evolution of cancer suppression mechanisms as the
49.
by reasonattlm 8y ago
The continued failure of efforts to remove amyloid by immunotherapy is provoking a lot of diversity in theory in the Alzheimer's community. This is economics 101: theorizing is cheap, running trials is expensive. Expect to see more of
50.
by reasonattlm 8y ago
This really has nothing to do with limits to longevity in any practical sense. That's just the publicity machine at work, the first line in mangling and misrepresenting the relevance of research. This paper is to do with a long-running
51.
by reasonattlm 8y ago
This study reports on attitudes to longevity that are reminiscent of the 2013 Pew survey [1]. When asked, people want to live a little longer than their neighbors, at the high end of the normal life span for old individuals today. When aske
52.
by reasonattlm 8y ago
The lead researcher here is the CSO of Oisin Biotechnologies, a company using programmable suicide gene therapy to kill senescent and cancerous cells. He is pretty productive.
53.
by reasonattlm 8y ago
Most of the cost is regulatory. But there is a meaningful difference between a world in which it costs $1M to screen and a world in which it costs $100k to screen. In the latter world, startups become viable with intent to find a drug candi
54.
by reasonattlm 8y ago
I think one of the bigger challenges facing Unity is that dasatinib plus quercetin may be just as good as anything they are rolling out. All of the animal studies of senolytic compounds fall into the category of either no meaningful effect
55.
by reasonattlm 8y ago
It is funny what does and does not catch the attention of the popular science press. This really isn't all that important as an example of research. It is a very incremental increment in exploring the connections related to cellular ho
56.
by reasonattlm 8y ago
"Healthy aging" is a oxymoron and people should stop using it. Aging is by definition a rise in mortality risk occurring due to the progressive failure of bodily systems. It is the opposite of health. You cannot age healthily. It
57.
by reasonattlm 8y ago
On the day it comes to you that living a longer, healthier life is something you'd like to do, that an extra year or ten of good health (or hell, why not more?) would be just peachy keen, think of the transhumanists - because you just
58.
by reasonattlm 8y ago
This captures the fundamental issues of incentives in this sort of thing. It takes a lot of money to run trials, and regardless of what is said about risk and what participants agree too, anyone suffering an adverse effect has a strong ince
59.
by reasonattlm 9y ago
Now think about how much better being old would be given the medical technology to repair the causes of frailty, functional decline, and age related disease.
60.
by reasonattlm 9y ago
https://www.scienceexchange.com $100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.

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