ramraj07

16 ms·

271.
by ramraj07 2y ago
Employees are fed up with managers who exist only to justify their existence as well.
272.
by ramraj07 2y ago
I agree with you that OPs ideas don't work. But I don't agree with you either. Let me point to a far more fundamental problem which is that even your well meaning lab is still a ponzi scheme that survives only because it gets chea
273.
by ramraj07 2y ago
Sometimes you do need to throw the baby with the bath water.. when you have sufficient evidence that the baby is dead lol. The amyloid hypothesis sucks ass, we have spent decades and hundreds of billions trying to make it work but we need t
274.
by ramraj07 2y ago
Given the current valuation of Tesla, it doesn't look very different from private market valuations. If anything private valuations seem more sane than the public market to me.
275.
by ramraj07 2y ago
It took me a second to figure out what the topic is, as a biologist. As a non biologist I feel this is an acceptable description of what's being described, I wouldn't consider this to be clickbait..
276.
by ramraj07 2y ago
How much of a slowdown did you estimate this bug caused?
277.
by ramraj07 2y ago
I would love to prove my point by actually becoming a billionaire, but my point is that the system is stacked against folks like me. Gotta have a nature paper to get a job in Genentech fresh out of PhD. Who gets nature papers? People who jo
278.
by ramraj07 2y ago
I am perfectly aware that this is the reason they blame for the insane costs - “we have to test so many drugs!” Yet you seem to have assumed I’m oblivious to the reality when I’ve already pressed I’ve been in the deep end and am aware. I’ve
279.
by ramraj07 2y ago
It’s ironic that you brought Alzheimer’s as an example since it exactly proves your point - drug companies pushed a therapy that targets a highly questionable _symptom_ of the disease, even though every single step of the process gave negat
280.
by ramraj07 2y ago
Have you experienced waymo in SF? It actually drives faster than regular folks and brakes much more harder because of that. The speed limit doesn’t apply to the streets of San Francisco and it typically accelerates to the limit as fast as p
281.
by ramraj07 2y ago
Absolutely, and if you recall, even YC tried to get in on this idea. Except they did the same mistake anyone who comes up with this disruption plan commits (including Google with Calico, or Zuck with CZI) - they recruit existing academics t
282.
by ramraj07 2y ago
Got my PhD from a lab that works on antibody drugs, they eventually even released one to the market. I’d argue that our current system is broken. There’s no reliable metric of drug effectiveness in any of our pre-clinical models, and thus w
283.
by ramraj07 2y ago
Author list, author affiliation and past history all suggest this might be a green card paper.
284.
by ramraj07 2y ago
Brilliant single line that is better than every other description above. Kudos.
285.
by ramraj07 2y ago
No one owes anyone open source. If they can make the business case work or if it works in their favor, sure.
286.
by ramraj07 2y ago
OP and the people who reply to you are perfect examples of engineers being clueless about how the rest of the world operates. I know engineers who don’t know Claude, and I know many, many regular folk who pay for ChatGPT (basically anyone w
287.
by ramraj07 2y ago
I think they’ll acknowledge these models are truly intelligent only when the LLMs also irrationally go circles around logic to insist LLMs are statistical parrots.
288.
by ramraj07 2y ago
Can’t remember anymore, but it’s either (a) the gp2 volumes were way too slow for the ops or (b) the IOPs charges made it bad. To be clear I didn’t do it on duckdb but hosted a Postgres. I moved to light sail instead and was happy with it (
289.
YC Isn't for Indian Startups(youtube.com)
2 points by ramraj07 2y ago|0 comments
290.
by ramraj07 2y ago
You just need to try it once to see the issue. Merely loading this amount of data onto a Postgres db will be hell.
291.
by ramraj07 2y ago
Test out the nvme drives though. It’s blazing.
292.
by ramraj07 2y ago
Lambda isn’t infinitely parallel. I thought it doesn’t do more than 100 parallel runners? I4i.metal has 96 cores and can be faster than that.
293.
by ramraj07 2y ago
Local drives. DONT USE EBS! you’ll incur a huge IO charge. You have to choose instances with attached nvme storage which means one of the storage optimized instances. Reading the data off s3 will mean you will be slower than offerings like
294.
by ramraj07 2y ago
I am just using duckdb on a 3TB dataset in a beefy ec2, and am pleasantly surprised at its performance on such a large table. I had to do some sharding to be sure but am able to match performance of snowflake or other cluster based systems
295.
by ramraj07 2y ago
It’s more accurate to say we are piecing together a thousand page book with just 20-50 sentences at random.
296.
by ramraj07 2y ago
Selfishness is the main reason life exists in the universe. Literally the only requirement for a lump of stuff to become alive is to become selfish. So you’re semi right that these LLMs can never become truly sentient unless they actually b
297.
by ramraj07 2y ago
Often they target the lowest performers for such layoff. Of course they rarely succeed in doing that, but the idea is that these people should have been let go anyway but weren’t for various reasons.
298.
by ramraj07 2y ago
US salaries are quite a lot more; lifestyle creep is a thing but at least for developers they get paid a lot more than the average worker in the US than say in the Europe. Factoring that, 4 months is amazing.
299.
by ramraj07 2y ago
FastAPI is a nobrainer choice of webserver backend for a python API server in 2024. If you’re not aware of that, then you really shouldn’t be commenting on this topic.
300.
by ramraj07 2y ago
Could you clarify what your problem with FastAPI here is? Also did I understand correctly that you’re not very well versed with python in general but still decided to criticize the decisions the model and the author made in that language?

More ›