r0ze-at-hn

8 ms·

31.
by r0ze-at-hn 7mo ago
Nearly 20 years ago after reading Diffusion of Innovations I decided to use everything in the book. The company ran off a few svn servers (formally cvs) and so I ran a handful of Git courses at my work to help us ultimately migrate to Git (
32.
by r0ze-at-hn 8mo ago
After spending years tracking through the genetics, conditions, lab work, research papers and seeing individuals years into the condition, this model is the best I have and explains everything I currently know. Why the cluster of condition
33.
by r0ze-at-hn 8mo ago
Cure is the wrong word. Alzheimer’s can be best described as a failure of a system and "debris" accumulates faster than it can be "cleared". There are many moving parts and everyone is unique about the cause of their sy
34.
The Alzheimer's Equation(metamagic.substack.com)
1 points by r0ze-at-hn 8mo ago|0 comments
35.
by r0ze-at-hn 9mo ago
> Benjamin, compared muscle stem cells isolated from young and old mice and discovered that a protein called NDRG1 increased dramatically with age—reaching levels 3.5 times higher in old cells than in young cells. So ERa down-regulates N
36.
Manifesto for AI Software Development: Code Is Cattle, Not Pets(metamagic.substack.com)
2 points by r0ze-at-hn 10mo ago|1 comments
37.
by r0ze-at-hn 11mo ago
My own my generic and more powerful git-map lets you run any git command on all repos at the same directory level. Simply putting the shell script in your path and then $git map status or $git map fetch etc https://github.com&#x
38.
by r0ze-at-hn 11mo ago
I suspect AI company want improved efficiencies and developing a framework that can be applied in determining the minimal-energy, maximal-efficiency architecture for ai models. Calculating the precise limits, like a Cognitive Event Horizon,
39.
by r0ze-at-hn 1y ago
I read the whole book. Sure an editor could have tightened it up, but it was an enjoyable tour of so many topics that I enjoy. So often I will read a paper or book on just one of the topics, seeing so many of them together was fun and made
40.
by r0ze-at-hn 1y ago
There are papers showing the common variants associated with intelligence. For example myelin sheath variants linked to intelligence as it increases fatty insulation around nerve fibers which speeds up transmission. But ones like that are s
41.
by r0ze-at-hn 1y ago
Something fun, you have a CYP11B1 rs4541 g;a Wouldn't surprise me if don't like Licorice. You also have something I don't see too often The CYP17A1 −34 T>C, rs743572(A;G) which compounds on that. Depends on the sum of all
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NCAH gene in Neanderthals led to intelligence, grain preference, and agriculture(metamagic.substack.com)
1 points by r0ze-at-hn 1y ago|0 comments
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by r0ze-at-hn 1y ago
Perhaps this is why creatures keep evolving eyes.
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by r0ze-at-hn 1y ago
> What I’ve found is that given a tool that can detect mistakes, the agent can often correct them This is the most important line of the entire article When iterating on a Manifesto for AI Software Development ( https://metamag
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Manifesto for AI Software Development: Code Is Cattle, Not Pets(metamagic.substack.com)
3 points by r0ze-at-hn 1y ago|0 comments
46.
A short history of Neanderthal intelligence(metamagic.substack.com)
1 points by r0ze-at-hn 1y ago|0 comments
47.
by r0ze-at-hn 1y ago
TikTokification of the browser by AI is the killer feature, not writing an email. When on a page it automatically suggests the next site(s) to visit based on my history and the page I am on. And when I say killer, this kills google search b
48.
by r0ze-at-hn 1y ago
Armchair geneticist: So in the group of genes that are deleted in particular LIMK1 stands out. After it is deleted there is only 1 copy behind. The other copy could be less effective as sometimes seen, but Estrogen in particular inactivates
49.
by r0ze-at-hn 1y ago
This is within the larger story of Homo Sapiens. Because CYP21A2 variants are much older and come from the primate tree there would have been continuous and separate adaptations on each branch. Homo Erectus improved language today and is as
50.
by r0ze-at-hn 1y ago
100% they were more advanced than early homosapiens. In fact I will argue that they are what made humans human. I went digging through their dna last year and Altai, Vi3315, and Vi3319 have the CYP21A2 rs6467 (C;T) variant Their DNA is u
51.
by r0ze-at-hn 1y ago
Very much related to this is "Chain-of-draft" https://arxiv.org/abs/2502.18600 Similar level of results in a fraction of the tokens resulting in similar quality for less cost for longer runs. But also when in
52.
by r0ze-at-hn 1y ago
I remember back in the early 2000's that discussion, but now with the the tonnage that systems like npm can pull in I laugh that we ever thought it wouldn't get worse.
53.
by r0ze-at-hn 2y ago
This is my educated guess on the topic having spent time investigating the intersection of poor memory, human growth patterns etc where this topic intersects: Norepinephrine is a key regulatory of memory. Before a certain age the body is mu
54.
by r0ze-at-hn 2y ago
And for the curious as I can't go back and edit the comment it was the Altai, Vi3315, and Vi3319 that have the CYP21A2 rs6467 (C;T) variant
55.
by r0ze-at-hn 2y ago
And there is so much still to uncover. Just the other day I was going through Neanderthal DNA during lunch and noticed that three of the four existing DNA samples show that they were carriers for the rs6467 form of Congenital Adrenal Hype
56.
by r0ze-at-hn 2y ago
Biologically I have low melatonin and low cortisol. This means I have trouble falling asleep and then I have trouble waking up. Countless times in my life I have lived 26-28 hour cycles and otherwise I am in a never ending struggle to live
57.
by r0ze-at-hn 2y ago
The ~2% that is kept in some humans and I have them and am walking among you. The majority of dna has to do with non-visible changes.
58.
by r0ze-at-hn 2y ago
Yes, the last few years there has been a big push to try to hide levels, don't celebrate promos as publicly, etc, but the overall you can't overnight change (if ever) a culture that has been built for two decades around this conce
59.
by r0ze-at-hn 2y ago
> author seems like they were only there for a promotion It is more the other way around. Internally google taught/teaches engineers that their only goal is promotion. All parts of this used to be very very public. There are whole p
60.
by r0ze-at-hn 2y ago
AGI. Writing up a paper on defining core principles of general intelligence on which artificial general intelligence can be built with a POC of an artificial life system that can evolve better AGI systems.

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