r0ze-at-hn

8 ms·

61.
by r0ze-at-hn 2y ago
I bought a NYC to Boston ticket for a few weeks from now for $35 this morning. Depends on many factors but once you know you can easily buy the cheap tickets.
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by r0ze-at-hn 2y ago
Hmm, couldn't that example be simplified to: SetUpdatedToNow - set %content.updated% as %now% in the file "file.txt" The whole reading and writing feels like a leftover from the days of programming. Reading it in, m
63.
by r0ze-at-hn 2y ago
> hire professional fakers and let them drive the company into the ground. This sounds like someone who is looking for someone to blame. If founder after founder is having this problem what are the odds that there is something else going
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by r0ze-at-hn 2y ago
The connection between autism and atypical estrogen signaling has been something I have been studying for a while. This paper explicitly mentions Aromatase, but there are other routes to have estrogen signaling insufficiency or excess such
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by r0ze-at-hn 2y ago
A way to look at this is that death is an evolutionary advantage for the species. Vertebrates have a PVN that control the HPA-Axis. As anything that contributes to the HPA-Axis such as pain, stress, or inflamation increases, the PVN shrinks
66.
by r0ze-at-hn 2y ago
This isn’t a surprise or shock. The Jaw bone development is highly influenced by sex hormone exposure. I personally look at the jaw bone (followed by the rest of the skull) before the pelvis when guessing the probable sex of a skeleton.
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by r0ze-at-hn 2y ago
The author is writing about the common story of how to grow and scale. Each team gets a product, spinning off teams, etc. What if like most products there is a ramp up period where you need a full team (or teams) and then a few years later
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by r0ze-at-hn 2y ago
I mean it is complex. You have genes like ADCYAP1R1 that are part of the turn on stress -> turn off stress loop. Variants in it lead to higher stress, but lower cortisol so so higher neurogenesis. So the group with the variants associate
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by r0ze-at-hn 2y ago
Actual paper: https://www.nature.com/articles/s41467-024-48153-z
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by r0ze-at-hn 2y ago
Which aspect of the Amazon design doc culture that you loved the most?
71.
by r0ze-at-hn 2y ago
Devs straight up tell you that they write design docs for the promo committee. That is their goal, everything else is secondary. Given that they never know which design docs they will use in their promo packet they put everything they wor
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by r0ze-at-hn 2y ago
The wording might have changed, but the culture is 100% still there and is draining fighting against it.
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by r0ze-at-hn 2y ago
I have a special interest in the post-mortem story of tech companies from the 70's, 80's, 90's, 00's. The HP, DEC, IBM, WordStar, RIM. I love the stories and the patterns they provide. Most companies reach a size and t
74.
by r0ze-at-hn 3y ago
Ah, well let me tell you about my pull request reviewer LLM project.
75.
by r0ze-at-hn 3y ago
For those that have not visited your local library lately. Along with books, I regularly borrow audiobooks, whole tv series, movies, switch and ps5 games. And they give me access to yet another movie and music streaming service that they
76.
by r0ze-at-hn 3y ago
Browsers often need to guess a file type
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by r0ze-at-hn 3y ago
I am already working with a doctor and have talked with those in academia. They find it neat, but are not going to jump projects, they already have their area of study that they are working to publishing something on, not this. There absol
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by r0ze-at-hn 3y ago
If you know one that wants to talk I am happy to. In the meantime it is being put to practical use today.
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by r0ze-at-hn 3y ago
For those old enough to program on punch cards you could say that is closer. We load the program into ram and then the env can and often does modify the program on the fly and we do dumb thing like use the current line number to save a by
80.
by r0ze-at-hn 3y ago
There has been some research mostly into gay men. But honestly the transgender data set is much richer. At the end of the day it is a minority that is being politicized so not exactly being investigated, but once you figure it out it is
81.
by r0ze-at-hn 3y ago
Been interviewed by a medical news journal and this has all been done in the public over the last year so there was never a “release date” or anything. Honestly at the start I was just another person with a guess. There are some scary imp
82.
by r0ze-at-hn 3y ago
To be clear this is/was a hobby project. Getting access to DNA files is required yes, but sequencing wasn't really the limiting factor. It started with simply poking around my DNA file and then some friends many of which were o
83.
by r0ze-at-hn 3y ago
I have given a few genetics talks this past year to technical groups and I start the talk by saying "This is no more difficult to understand than any event based system" [insert image of the Netflix micro services architecture] Th
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by r0ze-at-hn 3y ago
On #2 I have seen low dose naltrexone work really well which is amusing given its counterintuitive nature as an opioid antagonist. This was a fun puzzle to think about. My current best guess on how it work starts with the fact that when ta
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by r0ze-at-hn 3y ago
Sorry if you were looking for a single SNP or something simple. If that was the case this would have been found long ago. Same goes for a b vitamin. Giving vitamin b wont "cure them all". This is complex and happy to discuss o
86.
by r0ze-at-hn 3y ago
It is all pre-print stuff at this point. Here is a presentation that I gave last summer. Slightly out of date with some details given what has been learned since, but the main aspects are all there. The presentation focus's primarily
87.
by r0ze-at-hn 3y ago
Sure, email me (my email is in my about)
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by r0ze-at-hn 3y ago
It is not uncommon in the transgender community when someone transitions they will do a "full 180 switch". And of course this is never motivated by religion. This was actually one key point in helping me understand and figuring o
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by r0ze-at-hn 3y ago
When I was younger I learned that Sed was turing complete. So I did was any young woman would do. I build an entire search engine in Sed. But it wasn't like a useless little search tool that provided bad search capability for a web
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by r0ze-at-hn 3y ago
Option 3) Most businesses have a lifetime, most software has a lifetime, and one day they are run for the very last time. The same will happen for code written in C++, most of it will simply die. Some might live on in a GitHub repositor

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