pbreit

47 ms·

631.
by pbreit 7y ago
Can you point to evidence that in vitro efficacy rarely translates to in vivo? I've seen the one situation of chloroquine showing promise in vitro against SARS CoV but no others. Is there literature on others?
632.
by pbreit 7y ago
There is absolutely evidence of effectiveness against COVID-19 in humans from China, South Korea & France.
633.
by pbreit 7y ago
There was a lot of resistance until Elon & Trump mentioned it. The negative reaction to the French study has been pretty intense.
634.
by pbreit 7y ago
It's been confirmed effective against SARS CoV in vitro [1]. Before you say it, yes, I know treatments in vitro do not always work in vivo. Reports from China, South Korea and France have suggested efficacy in humans against COVID-19.
635.
by pbreit 7y ago
90 years. By millions of people. Also for arthritis and Lupus.
636.
by pbreit 7y ago
The main reason chloroquine is getting criticism is because Trump mentioned. This is utterly insane.
637.
by pbreit 7y ago
There is...both in vitro and in vivo. The pushback on chloroquine is completely insane. It's a 90 year old, well-understood drug used safely by millions with mild side effects.
638.
by pbreit 7y ago
It's a prescription drug (unless you're ingesting the aquarium cleaner). No one is recommending self-medication. Two people having a bad reaction suggests highly improper usage. Do you dislike it mainly because Trump mentioned it?
639.
by pbreit 7y ago
"The suggestion on the table is to give this drug to extremely ill patients" No. Likely needs to be given closer to onset of symptoms. "The suggestion was to massively prescribe it." No. The suggestion is to generate mor
640.
by pbreit 7y ago
I'm not sure if any of what you wrote is accurate. The drug is 90 years old, has been used by millions, has relatively modest side effects, is relatively well-understood, has shown efficacy against coronavirus in vitro.
641.
by pbreit 7y ago
"no reason to think that they couldn't have done that in the same amount of time with the same amount of effort" There is EVERY reason to think they were not in a position to a "proper" test. They are in the middle
642.
by pbreit 7y ago
Does this doc record actual usage? What are you basing "it has at best a marginal effect" on?
643.
by pbreit 7y ago
I’m wondering what took so long? Shouldn’t we be ready to do something like this almost immediately? Still seems chloroquine is required to meet a higher bar than the others which continues to be odd.
644.
by pbreit 7y ago
Even if true (I don't really believe it), very temporary. The article I cited suggests 200 million doses are on their way.
645.
by pbreit 7y ago
You shouldn't be getting it. It's prescribed in most 1st world countries. It should not be used as a prophylactic at this time. Its use should be prescribed and monitored by a doctor.
646.
by pbreit 7y ago
Supply is not an issue: https://www.fiercepharma.com/pharma/new-commitments-mylan-an... We need testing that the medical community will accept.
647.
by pbreit 7y ago
Do you have a link?
648.
by pbreit 7y ago
OP called it "quite flawed". But it is most definitely evidence.
649.
by pbreit 7y ago
Agree with all except wondering what you mean by the safety profile being not great? It's been around for 70 years, taken by millions over very long periods of time with relatively minimal negative side effects.
650.
by pbreit 7y ago
I don't know. But there's more than enough available now. https://www.fiercepharma.com/pharma/bayer-preps-u-s-donation...
651.
by pbreit 7y ago
It's taken regularly by millions. Are the side effects really that nasty?
652.
by pbreit 7y ago
It may not work as a prophylactic (preventative measure) and in fact, as an immunosuppressant, may actually make things worse. For example, it enhances influenza: https://www.ncbi.nlm.nih.gov/pubmed/25715935
653.
by pbreit 7y ago
WARNING: the above is almost certainly wrong. Citation should be provided. The preponderance of the evidence suggests that it's a well-understood drug that has been around for decades, used by 10s of millions for not only malaria but a
654.
Covid-19: Could Hydroxychloroquine Be the Answer?(medscape.com)
3 points by pbreit 7y ago|0 comments
655.
by pbreit 7y ago
If you're having problems with Stripe, you're probably going to have more problems elsewhere.
656.
by pbreit 7y ago
This made me think id need to do something on the DB server which I cannot: “On your database server, run the following to install autossh”
657.
by pbreit 7y ago
How is this virus related? Can anyone confirm this is new behavior or that there is not an explanation?
658.
by pbreit 7y ago
If I understand, it involves changes to the DB server? That would be a show-stopper for me.
659.
by pbreit 7y ago
Looks interesting. Alas, no support for VPNing into DB. Like what mode.com is doing with its "bridge": https://mode.com/help/articles/how-mode-connects/#bridge
660.
by pbreit 7y ago
I wonder if selling, perhaps at a discount, to a relatively passive secondary buyer like Industry Ventures would have been an option?

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