oasisbob

22 ms·

301.
by oasisbob 4y ago
This reminds me of what I've seen happen with the internal health-check endpoint often added to APIs. Simple at first, but eventually there are endpoints to cause the health-check to synthetically fail for deployment purposes; the heal
302.
by oasisbob 4y ago
> Yes, I'm not from USA, and we don't have any cards with real cash-back. Typically exchange rate for all banks in my country is like xe.com + 3-5%. It is terrible. Ahh, now I understand where the disagreement is coming from. F
303.
by oasisbob 4y ago
I've been to most of those countries, and they're no exception to the rule that the best exchange rates will be provided by the credit card networks. Though, Cambodia is strange--at least to someone from the US--since the USD is s
304.
by oasisbob 4y ago
Most people agree the best rates are obtained if the transaction is done in local currency with the network providing the conversion. However, some ATMs and credit card terminals give the option to either send the transaction to the network
305.
by oasisbob 4y ago
re: sink washing... I spent most of 2019 in SE asia, and full-service laundry was just too good, universal, and cheap to pass up. About a euro/kg everywhere. Never any problems. Sink washing and dealing with damp clothing was a time su
306.
by oasisbob 4y ago
You would think so... On the other hand, Zwave radio spectrum varies depending on region, so you need to be very careful that you don't spend hours troubleshooting something that doesn't work because it's a device intended fo
307.
by oasisbob 4y ago
ploink Enjoy your sealioning.
308.
by oasisbob 4y ago
I think it might be productive to dive in on this part > Loosely, that's the observation that (stochasticity of spread aside) we'd expect the earlier lineage A to have more and more diverse descendants than the later lineage B.
309.
by oasisbob 4y ago
> (with p ~ 10%) in a single human-to-human transmission. That math is absolute garbage. One, the odds of a C/T -> T/C double mutation in a single transmission for the clade-defining markers isn't the same as T/C -
310.
by oasisbob 4y ago
> Not only is their argument for two introductions not a standard molecular clock approach, but it's not a molecular clock approach at all, since "Inferring" provides no support Okay, lets revisit this now that some of the
311.
by oasisbob 4y ago
Yeah, I think we're basically on the same page with their methodology and models now. I didn't realize you were nicknaming the models based on applying them to the result titles, so was quite confused, especially when we both used
312.
by oasisbob 4y ago
> Even if SARS-CoV-2 really entered humans in December, with minimal cryptic spread, that's still enough time for the two lineages to evolve in humans, since they're (sorry) just two SNPs apart. This isn't the evidence the
313.
by oasisbob 4y ago
Their results of the simulations are stochastic. They discuss this in-depth, as it complicates their analysis. I don't understand what you're trying to say. Everyone agrees that the spread is stochastic. Why are you starting with
314.
by oasisbob 4y ago
Glad we're on the same page about the multiple techniques now. Statements you made like, "Pekar et al. do some complicated phylogenetic modeling that purports to show the MRCA in humans is too recent" and "This isn'
315.
by oasisbob 4y ago
> In particular, why choose to study robustness against doubling time (which seems intuitively like it wouldn't affect the shape of the tree much) As I understand it, the doubling times observed in the simulations were primarily th
316.
by oasisbob 4y ago
Yes, I've reviewed the supplemental materials. > because nothing else excludes an earlier (even September) first introduction into humans. With an earlier introduction and thus more extensive unsampled spread, it's much harder
317.
by oasisbob 4y ago
> A typical molecular clock approach wouldn't give anywhere near the accuracy necessary to exclude evolution of lineage B (just two SNPs away) in humans You're ignoring other data which is counter to the idea of B evolving from
318.
by oasisbob 4y ago
Canopy coverage is a fine measure. It's equating the number of trees with canopy cover with carbon sequestration which is at issue. The original study isn't what I'm commenting on. eg, Younger forests are not as productive as
319.
by oasisbob 4y ago
The writer is clearly conflating canopy coverage area with individual trees.
320.
by oasisbob 4y ago
I believe this piece is referring to this 2018 Nature paper: https://www.nature.com/articles/s41586-018-0411-9
321.
by oasisbob 4y ago
> Daszak made strenuous efforts to hide [...] that the signatories to the letter had any connection to EcoHealth Alliance or the Wuhan Institute That's a strange thing to argue given that Peter Daszak's position within EcoHealt
322.
by oasisbob 4y ago
> 2. There is also no evidence that the epidemic had no lab involvement The timing of the A and B lineages spreading at the same time strongly indicates multiple spillover events.
323.
by oasisbob 4y ago
> If you read the papers that claim natural origin, these turn out to be extremely weakly argued. What didn't you like about Pekar 2022?
324.
by oasisbob 4y ago
Arris DOCSIS modems probably still have a lot of Motorola DNA in them since Arris's 2012 acquisition of Motorola Home. I have a box somewhere with near-identical Motorola/Arris surfboards other than the logo and color.
325.
by oasisbob 4y ago
Numerical sludge. Got it. Enjoy your criticism.
326.
by oasisbob 4y ago
> all of Worobey's or Pekar's reasoning starts from the assumption that there was no significant cryptic (unsampled) human spread. They don't assume that. See the discussion in Pekar. ("The high extinction rate [...]
327.
by oasisbob 4y ago
I don't take two lineages to be conclusive evidence of multiple zoonotic events. However, the multiple polytomies for each are not easy to explain away. Have you read Pekar's most recent paper in Science? I raise this in earnest,
328.
by oasisbob 4y ago
> They're just two single-nucleotide polymorphisms apart The problem with that argument, is that it doesn't explain the polytomies and is misleading, as you accuse Worobey of being. "Just a few SNPs" is disingenuous a
329.
by oasisbob 4y ago
> There were two variants in the market... No, there were two distinct lineages in the market. That's different than variants. The lineages are important because although the differences between the sequences are small, they are dis
330.
by oasisbob 4y ago
> This is of course a lazy theory and would be nearly impossible to test out. Even this hypothetical theory doesn't explain the early lineage A / lineage B split and is not supported by existing data.

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