nwienert

20 ms·

301.
by nwienert 2y ago
My want is for relieving pain in the body without making me feel high, I actually assumed you want it in the body not brain, as the brain effects are the feel-good effects, but really not sure or familiar with how they work.
302.
by nwienert 2y ago
Yes but loperamide doesn't alleviate pain, which maybe just that opioids only alleviate pain if they do reach the brain, but I did see trials for non-bbb crossing ones that were for pain so not sure what's going on there.
303.
by nwienert 2y ago
Looks like the antagonist is only outside the brain, so it works to counteract the side-effects, pretty cool. I wanted sort of the opposite of this for opioids - work in the body, not the brain. There's been a few attempts but non that
304.
by nwienert 2y ago
I have plenty of nightmare stories to tell you about native deps.
305.
by nwienert 2y ago
You can make a disaster in any framework. SwiftUI is a mess, for example, and slow. React Native took a while to mature, but with the right tooling you can ship amazing UX now. I don’t doubt there’s a ton of crap out there. But you’re wrong
306.
by nwienert 2y ago
I'd say most of the time it's a handful of times or less. Uniswap is a good example of a large OSS three-platform app that shares almost all the code, uses very few native dependencies, and has great UX. I maybe biased since I wor
307.
by nwienert 2y ago
I was trying to get 4o today to do some medium-difficulty Typescript to map between two different ORM schemas. It's a great problem because it's really not too hard, pretty well constrained, and I can provide a ton of context and
308.
by nwienert 2y ago
Google controls information and the wider marketplace, Apple controls hardware and a smaller marketplace, imo they're going after the right one first.
309.
by nwienert 2y ago
The social good would be not carving out for OAI, if we want to maintain a culture that rewards human creative output (which also happens to be what models need, so it's a win-win). The good news is it's not true that OAI can&#x
310.
by nwienert 2y ago
The first reply on the issue you linked seems incredibly professional and well handled, and even recommends excluding the file from backups, I can't see a single issue there.
311.
by nwienert 2y ago
I don’t trust you or anyone to be the moderators of what’s rational and what’s working back from what they want, though, in all honesty. Further, the people working backwards sometimes end up right anyway. I just don’t see the risk of letti
312.
by nwienert 2y ago
if they can get the better screen from the pro into an air it'd be ideal
313.
by nwienert 2y ago
You didn’t say to slow down and wait, you made the claim that “something’s probably bad”, quite different.
314.
by nwienert 2y ago
I'm all for conspiracies, but didn't a rare type of storm hit the boat?
315.
by nwienert 2y ago
This is a "trust me bro" reply though, there are constant developments in research chemicals that aren't easily detected. I know a top-20 boxer who thinks doping is common it's just harder to detect now. Perhaps at lower
316.
by nwienert 2y ago
How do you know doping is rare?
317.
by nwienert 2y ago
Something can be highly rated and still under-rated, which is my claim. Almost no one knows about the effects beyond weight loss, and people who do often believe it's due to weight loss or fasting.
318.
by nwienert 2y ago
They are very, very different, almost not worth comparing.
319.
by nwienert 2y ago
GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people.
320.
by nwienert 2y ago
The person I'm replying to surely on the left based on: 1. their comment history here 2. the account on X they reposted 3. the motivated reasoning they are displaying and avoidance of acknowledging logical alternatives Further the left
321.
by nwienert 2y ago
if you believed it was real you are too easily motivated by your own bias, it was spaces compression seen many times in other spaces
322.
by nwienert 2y ago
It's orthogonal to the diet, I actually force myself to eat normally including eating carbs, I actually take it specifically only because it has a strong positive effect on my immune system. There's some research showing as much.
323.
by nwienert 2y ago
It's definitely not a fallacy that things that relieve pain can also help heal or prevent damage, NSAIDs are a great example. It mentions it may do more than just blocking the signal in the article.
324.
by nwienert 2y ago
Pathways that remove pain can be due to healing though, it's a mildly positive indicator.
325.
by nwienert 2y ago
I found some relief in the GLP-1 agonists, a surprising amount actually, and that was not due to any weight loss.
326.
by nwienert 2y ago
You can use Playwright with Webkit, which is much lighter weight than Chrome.
327.
by nwienert 2y ago
No it's separate from the obesity effects. For me I have both Familial Mediterranean Fever and hypermobile Ehlers Danlos, I get consistent effects from them (~monthly basis) but since Tirzepatide have had none now nearly 2 years. I can
328.
by nwienert 2y ago
Fixes immune system issues too, I can say firsthand it's a near miracle for mine, and I wasn't overweight or out of shape when I went on.
329.
by nwienert 2y ago
What are you selling?
330.
by nwienert 2y ago
So if someone after two weeks had their semen consistency change to be completely watery, would it be their eyes that produced the nocebo effect or? Or how is the doctor who went on it for a few months, lost erections, then gained them back

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