4 ms·

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases?publication_id=89120&post_id=147025858&isFreemail=true&r=3l29m&triedRedirec

GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases?publication_id=89120&post_id=147025858&isFreemail=true&r=3l29m&triedRedirect=true https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers, and heart and kidney disease. I also think they are underrated and there may be some alpha in them for a few reasons: 1. People seem to hate the idea that someone can "cheat" at losing weight, almost seeming to hope they have some unknown side effect. 2. People seem to dismiss them as "only working because obesity causes all those issues", probably the biggest fallacy as we have evidence already, and I think will find much more, that the addictive, immune, kidney and heart effects are not due to weight loss/fasting. 3. People don't seem to realize how huge a deal it is if they do have a strong effect on immune issues - immune system issues underly so many health issues of different names from allergies to Alzheimers to all sorts of terrible diseases, and I now know a couple non-overweight people who have reported nearly miraculous results with them. 4. Their effects on addiction likewise just by themselves are big. Another friend/smoker since high school, smokes nearly a pack a day tried it and for the first time since HS didn't smoke a cigarette for a whole day - multiple days in a row. BTW it seems tirzepatide is significantly better for at least some of these effects than semaglutide.

user_7832 2y ago
What's slightly interesting to me is that some effects of adhd medications (particularly methylphenidate) sound quite similar - it too (can) change motivation regarding food (and actually can make unhealthy donuts seem disgusting) and of course suppresses apptetite (sometimes a little too much). I'd love to know if anyone who's taken both mph & a GLP-1 agonist how similar/different they are. (There's other interesting aspects of mph too - like how it can change sensitivities - and actually make light mode not feel like your eyes are on fire! - but that's a comment probably for another time.)
- nwienert 2y ago
  They are very, very different, almost not worth comparing.
_nalply 2y ago
There’s one dangerous effect of a GLP-1 agonist: delayed emptying of the stomach during surgery. Usually, the stomach should be empty due to the risk of complications (like aspiration). But when one takes a GLP-1 agonist, it is not enough to fast on the same day. When planning surgery, you need to talk with your surgeon. One solution could be to stop taking the agonist seven days before surgery and fast for 24 hours. There’s an insidious issue: uninformed people tend to quickly assume that the patient is weak-willed and ate even if instructed to come NPO.
Vecr 2y ago
The "with diet and exercise" clause is not a joke. You need to think about your nutrition, including protein. Even with a good diet, you're going to lose muscle mass if you don't exercise.
marcinzm 2y ago
> I also think they are underrated Not sure if one can call a set of drugs that are so in demand as to be basically impossible to get at times underrated. Possibly random people online say otherwise but the market says the opposite very strongly.
- nwienert 2y ago
  Something can be highly rated and still under-rated, which is my claim. Almost no one knows about the effects beyond weight loss, and people who do often believe it's due to weight loss or fasting.

user_7832 2y ago

What's slightly interesting to me is that some effects of adhd medications (particularly methylphenidate) sound quite similar - it too (can) change motivation regarding food (and actually can make unhealthy donuts seem disgusting) and of course suppresses apptetite (sometimes a little too much). I'd love to know if anyone who's taken both mph & a GLP-1 agonist how similar/different they are. (There's other interesting aspects of mph too - like how it can change sensitivities - and actually make light mode not feel like your eyes are on fire! - but that's a comment probably for another time.)

nwienert 2y ago
They are very, very different, almost not worth comparing.

_nalply 2y ago

There’s one dangerous effect of a GLP-1 agonist: delayed emptying of the stomach during surgery. Usually, the stomach should be empty due to the risk of complications (like aspiration). But when one takes a GLP-1 agonist, it is not enough to fast on the same day. When planning surgery, you need to talk with your surgeon. One solution could be to stop taking the agonist seven days before surgery and fast for 24 hours. There’s an insidious issue: uninformed people tend to quickly assume that the patient is weak-willed and ate even if instructed to come NPO.

Vecr 2y ago

The "with diet and exercise" clause is not a joke. You need to think about your nutrition, including protein. Even with a good diet, you're going to lose muscle mass if you don't exercise.

marcinzm 2y ago

> I also think they are underrated Not sure if one can call a set of drugs that are so in demand as to be basically impossible to get at times underrated. Possibly random people online say otherwise but the market says the opposite very strongly.

nwienert 2y ago
Something can be highly rated and still under-rated, which is my claim. Almost no one knows about the effects beyond weight loss, and people who do often believe it's due to weight loss or fasting.