nonbel

22 ms·

181.
by nonbel 8y ago
Yes, they are grouping together the (lets call them) "DARE drugs" with "medical drugs". Presumably this is strategic to hide whatever issue is going on with the "medical drugs" and inflate the apparent problem
182.
by nonbel 8y ago
You may be interested in this: https://news.ycombinator.com/item?id=19328202 Apparently the mortality rate from ICD-10 X44 (stuff like blood pressure medication, antibiotics, etc) causes has risen more than 5x over the last
183.
by nonbel 8y ago
Funnily enough, I happened to be on the page that answers this. Page 160: "Alcohol-induced deaths and drug-induced deaths are mutually-exclusive. However, these deaths may also be considered suicide deaths." Also, I can't fin
184.
by nonbel 8y ago
I wanted to see what ICD-10 codes they used for "drugs" since I have seen similar claims before that grouped in "drug" over/under-doses in a general sense. Ie, it included stuff like deaths from blood pressure medic
185.
by nonbel 8y ago
The ~600 BC Egyptians claimed it was because the proximity to water protected them from periodic "great conflagrations" and the lack of rain from catastrophic flooding: > "There have been, and will be again, many destruct
186.
by nonbel 8y ago
I'm not clear on what "new physics" means in that paper. It could mean "standard model + this new particle", but I will take your word for it if you say otherwise.
187.
by nonbel 8y ago
I always wonder about the "bump" from a few years ago when hundreds of possible explanations (presumably all consistent with the standard model) were published before it was decided to be "random noise". > "In th
188.
by nonbel 8y ago
Thanks. It seems technically possible to stop a great deal of these robocalls with that info.
189.
by nonbel 8y ago
How does it identify spoofed numbers?
190.
by nonbel 8y ago
It never made much sense to me that the providers would not offer some kind of robocall-free plan. I would instantly switch to avoid getting any more of these spoofed calls, which would block the vast majority of robocalls. It turns out tha
191.
by nonbel 8y ago
> "When your looking at preclinical trials it’s more like 300 people and 5000 mice per trial and god knows how many trials before something goes through." This is sampling to a foregone conclusion. It is guaranteed to yield unr
192.
by nonbel 8y ago
How many of these drugs actually do work in mice? Every study that comes out on the topic shows at least 50% and often closer to 90% of preclinical research does not replicate or even is not replicable in principle.
193.
FRIN: Further Research Is Needed(en.wikipedia.org)
3 points by nonbel 8y ago|0 comments
194.
by nonbel 8y ago
> "But the amount of energy being used to mine bitcoin is a real problem - it's not just a technical challenge (like the problems above). This is something that literally affects every human being ... But we need to talk about
195.
A review of explanations of anomalous observations during solar eclipses(arxiv.org)
2 points by nonbel 8y ago|0 comments
196.
by nonbel 8y ago
Which is easier for a rich person? 1) To pay off a few politicians 2) To sell a product/service to millions of people I'd say it is usually the first. If you are already rich and powerful it is in your interest for the government
197.
by nonbel 8y ago
Can they get a polynomial regression to play mariokart from screenshots and button push data? https://www.kevinhughes.ca/blog/tensor-kart
198.
by nonbel 8y ago
Where did you learn about the concept of "free markets" though? Is it the school system of a certain country? A website? I don't mean to try to hide why I am asking, it is because trying to tie a situation like this to "
199.
by nonbel 8y ago
> "the free market won't fix this." I've been seeing a large increase in comments like this across the internet. Can you share where you learned the definition of "free market"?
200.
by nonbel 8y ago
Interesting, thanks for the history.
201.
by nonbel 8y ago
Thanks. It is also not clear to me after a quick search whether any amyloid has been called "infectious" other than ones derived from the PRNP sequence. It is very interesting.
202.
by nonbel 8y ago
> "so far all symptoms of prion-type disease for which a cause has been found have turned out to be associated with errors in PRNP." Thanks, this is an interesting new fact to me if true. Is there a source for it? I don't
203.
by nonbel 8y ago
Or a symptom of aging. As for a proxy I doubt it would be much better than actual age.
204.
by nonbel 8y ago
I would think it is a good idea to assume they are a symptom but could also cause further problems. Just like sneezing/coughing does occur normally, but is also a symptom of many different health issues, and in the worst cases could le
205.
by nonbel 8y ago
You don't share any links, but how would you reconcile this with the claims that amyloids are widespread. I posted about it here: https://news.ycombinator.com/item?id=19129157 Is it really the case that PRNP ( https:&#
206.
by nonbel 8y ago
Not a bad idea in principle. In practice you have to figure out a way to detect them non-destructively (eg via light interacting with it in the tissue or some metabolite in excretions).
207.
by nonbel 8y ago
I plan to. I was similarly ignorant until I looked into the topic of natively unfolded peptides for a different reason (anomalous western blot results). If you have any examples of these "uninformed scientists" on display it may b
208.
by nonbel 8y ago
An increase in amyloids will be observed any time cells are malfunctioning for whatever reason. They are the most thermodynamically stable structure that polypeptides can form, and require constant housekeeping to prevent. Accumulation of a
209.
by nonbel 8y ago
Amyloid-Beta is a specific instance of amyloids, while prions are a class of amyloids: > "Some amyloid proteins are infectious; these are called prions in which the infectious form can act as a template to convert other non-infectio
210.
by nonbel 8y ago
You could just go to that site and experience the "infinite scrolling" to figure out that this is "information" meant for fools.

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