5 ms·
>"so far all symptoms of prion-type disease for which a cause has been found have turned out to be associated with errors in PRNP." Thanks, this is an interest
by nonbel 8y ago
>"so far all symptoms of prion-type disease for which a cause has been found have turned out to be associated with errors in PRNP."
Thanks, this is an interesting new fact to me if true. Is there a source for it?
I don't mean a source proving there are no others or something else silly like that. I mean like a review article that mentions they couldn't find any publication about any amyloid beyond PRNP-derived ones being transmitted.
- escape_goat 8y agoI can't give you a source like that. From the Wikipedia article on prions, it appears that several prion-based diseases are suspected, but that so far the only proven cause for such a disease has been the "major prion protein." In 2015 a hypothesis was advanced that multiple system atrophy (Shy–Drager syndrome) was caused by a prion form of the alpha-synuclein molecule. However, if any subsequent proof has followed, neither the wikipedia pages on prions or alpha-synuclein have caught up with that.