nicwilson

9 ms·

61.
by nicwilson 5y ago
The determination of whether to proceed with medical intervention is usually done with a metric called quality adjusted life years (QALY: which is life years adjusted by quality of life), or rather they are never done if QALY is negative. A
62.
by nicwilson 5y ago
I'm guessing something like e.g. Alzheimers or some other quality of life degrading, but not lethal, disease that makes life (not as) worth living, at least past a certain point in the progression of the disease. But because its not le
63.
by nicwilson 5y ago
I think you mean something other than circumvents, circumnavigates? Also https://en.wikipedia.org/wiki/Arctic_tern
64.
by nicwilson 5y ago
This one is very recent: https://www.youtube.com/watch?v=OXtq4a8829g
65.
by nicwilson 5y ago
With no context, that sounds like a trading term to me, like "a put".
66.
by nicwilson 5y ago
Probably computational fluid dynamics
67.
by nicwilson 5y ago
> - kids under 16 cannot get to any high school other than their assigned one because they can’t drive (and at 16 they’d need a car, which not everyone can afford) Is the density of high schools _that_ low and availability of transport _
68.
by nicwilson 5y ago
This was also available for people who were going into apprenticeships
69.
by nicwilson 5y ago
presumably increased metabolic activity which equates to increased (epi)dermal turnover (among many other factors, e.g. immune surveillance). Increased turnover leads to more chance for errors during replication
70.
by nicwilson 6y ago
> We decided on compiler error instead of emulation DMD does that, LDC (based on LLVM) does the sensible thing and vectorises with the widest available native SIMD. No idea what GDC (based on GCC) does.
71.
by nicwilson 6y ago
Ah good, you are still hiring. I sent you an email a couple of weeks ago but never heard back, I guess I got stuck in your transition from angel.co or got sent to spam? I'll send another.
72.
by nicwilson 6y ago
Very interesting, I was going to do something very similar, I've sent you an email.
73.
by nicwilson 6y ago
The problem is the 'collateral', which is facebook covering their asses, includes such useful services as the Bureau of Meteorology and government health departments in addition to the expected targets.
74.
by nicwilson 6y ago
> No he's not. He's a left-leaning centrist, like both major Australian parties What? He's a money worshiping pentecostalist (and I mean that in a literal sense). The LNP are pretty far right. They're no one nation, b
75.
by nicwilson 6y ago
> because sexual orientation is immutable, Not entirely true, I remember there was a case where an English rugby player received a concussion and was put in an induced(?) coma and was gay after he woke up. However we certainly don't
76.
by nicwilson 6y ago
because thats not what mRNA and normal cellular processes do and there is no mechanism in the body to allow that to happen. Reverse transcription only happens when a reverse transcriptase (found in retro-viruses, e.g. HIV-1, HIV-2, Hepatiti
77.
by nicwilson 6y ago
They are made by https://en.wikipedia.org/wiki/Thymic_epithelial_cell (see the section on Positive and negative selection) as part of the selection process.
78.
by nicwilson 6y ago
Without knowing which auto-immune disease its hard to give more information (which is fine, this is not medical advice). > So if I understand you correctly, the self-recognition system is something built-in Yes. before immune cells are r
79.
by nicwilson 6y ago
Ah, I had assumed you were talking about the vaccine immune response. > we would all die 100% of the time if adjuvent was required to mount immune response, to infection. Indeed, but it is required for a vaccine to function properly.
80.
by nicwilson 6y ago
> assuming that host cells start expressing the spike protein, and the immune system learns to react to it, Firstly they only express it as long as the mRNA remains intact. mRNA are degraded naturally so there is a finite time window as
81.
by nicwilson 6y ago
What? > adjuvent [sic] is not neccesary[sic] for immune response, Completely false. Unless the immune system has been exposed to something similar before (e.g. SARS/MERS n.b. made up example I have no idea if the spikes of SARS or M
82.
by nicwilson 6y ago
It doesn't. The vaccine is a piece of mRNA (in this case part of the spike protein) which has a cap on one end to stop degradation from the start of the message (which would garble it completely). This piece of RNA is not replicated.
83.
by nicwilson 6y ago
No. Yes. This approach is like sneaking in blueprints to a factory (cell) that makes (proteins using mRNA) whatever it has blueprints for, and gets inspectors that come around occasionally (immune surveillance), or very frequently under act
84.
by nicwilson 6y ago
It still dilates the northern hemisphere and squashes the southern hemisphere though.
85.
by nicwilson 6y ago
Yeah, think of it like Nettle. Except painful enough to cause horses to jump of cliffs. Read the wikipedia article of them, its great. I love the part that recommends applying dilute hydrochloric acid to the exposed skin to dissolve the nee
86.
by nicwilson 6y ago
When you use it to hide the breath of an alcoholic, yes.
87.
by nicwilson 6y ago
The only way that analogy works is with some kind of self replicating prion disease, which would get selected out pretty quickly. The main fallacy that people tend to make drawing comparisons with biology and computers is the degree to whic
88.
by nicwilson 7y ago
> Droughts are caused by depleting the water supply, not by warm weather. Warm weather increases rain. It also increases evaporation an even the size and geography at play they don't even come close to cancelling out. >>seas t
89.
by nicwilson 7y ago
This misses the use of the AI model for prediction, search and optimisation, backed up by simulation for verification. > it is basically useless, as presumably the verification of a solution takes as long as a classical simulation. If an
90.
by nicwilson 7y ago
The classic antiviral* is a modified nucleotide, e.g. 5-fluoro-Uracil, that buggers up viral DNA/RNA reproduction and causes substrates to stick to the enzymes that transform them causes them to not work. The resistance is developed by

More ›