The classic antiviral* is a modified nucleotide, e.g. 5-fluoro-Uracil, that buggers up viral DNA/RNA reproduction and causes substrates to stick to the enzymes

The classic antiviral* is a modified nucleotide, e.g. 5-fluoro-Uracil, that buggers up viral DNA/RNA reproduction and causes substrates to stick to the enzymes that transform them causes them to not work. The resistance is developed by the enzymes changing to not stick to the drugs. This in contrast seems to be membrane disruption, i.e. bursting and disintegration of the viral membrane, which is host derived and thus the virus has no control over apart from any proteins it add to it (e.g. gp120 for HIV) and is therefore much. *that isn't aiding the immune system in some way N.B I haven't finished reading the paper yet. so take it with a grain of salt.