nfusi

4 ms·

1. 1.▲
   by nfusi 9y ago

   No, there was no leakage. We trained on one dataset and evaluated on a completely different one, then did the reverse to show that the model generalized well irrespective of the training data (Figure 2). The decision of which model to deplo
2. 2.▲
   by nfusi 9y ago

   Yes, this is correct. We developed a series of ML models to predict 1) whether a given guide RNA is likely to result in the knockdown of a gene 2) whether a guide RNA is likely to produce unintended effects somewhere else in the genome. Als
3. 3.▲
   by nfusi 9y ago

   I'm one of the authors. Predictive models like ours are useful for sorting through thousands of potential guides/sites and scoring them. In the paper associated with the service https://www.nature.com/articles&#x2F