mrosett

11 ms·

181.
by mrosett 7y ago
The first immunotherapy was approved in March 2011. An article from 2017 listing diseases with approved immunotherapies misses fully 1/3 of the years (3 out of 9) in which immunotherapies have been approved.
182.
by mrosett 7y ago
Thanks!
183.
by mrosett 7y ago
Look, just because a bias exists doesn't mean that it explains every single bit of improvement. We have randomized controlled trials showing that these drugs work.
184.
by mrosett 7y ago
Most of the indications for immunotherapy are cancers with solid tumors. This source [0] is a bit dated (2017) but it contains a chart showing which cancers had an indication for immunotherapy at the time, and they're almost all solid
185.
by mrosett 7y ago
100% agree. In fact, even specific cancers are really a collection of disease. For instance, breast cancer is many different diseases defined by different mutations/receptors and with correspondingly different treatment approaches.
186.
by mrosett 7y ago
Sure, that can show up in aggregated statistics. But it used to be that there was no treatment for all sorts of metastatic diseases. Now there are. That's not a function of earlier detection. This isn't made up; we have real RCTs
187.
by mrosett 7y ago
Re: cost - you're conflating two different things. The cost of new drugs at the time of introduction has gone up. The new drugs of 2020 are more expensive than the new drugs of 2000. However, with a few high-profile exceptions, the cos
188.
by mrosett 7y ago
Thank you for writing a more concise version of what I tried to write below.
189.
by mrosett 7y ago
There are a lot of statistical fallacies like this: > The current age-adjusted mortality rate for all cancers in the U.S., 152.4 deaths per 100,000 people, is just under what it was in 1930, according to a recent analysis. The US is a ve
190.
by mrosett 7y ago
So I'm looking back over what he wrote: > Immune therapies, which seek to stimulate immune responses to cancer, have generated enormous excitement. Two researchers won the 2018 Nobel Prize for work related to immune therapies, and a
191.
by mrosett 7y ago
This article is a case study in “if you say something controversial enough, people will pay attention regardless of the quality of your argument.” There’s a lot of hype in the cancer industry and there are still many diseases that can’t be
192.
by mrosett 7y ago
They had no choice. I don’t give any weight to their denials.
193.
by mrosett 7y ago
I thought Apple pay was really dumb... and then I started using it. Especially with an Apple Watch: when I get to checkout, I can fumble with my wallet, dig out a card, wait ten seconds for the chip to read, and then put the card away.... o
194.
by mrosett 7y ago
Kaepernick landed as the face of Nike with a massive endorsement deal for his trouble, which I guess is sort of like being sent to a a work camp.
195.
by mrosett 7y ago
/r/exmormon has a very particular perspective, largely driven by the people who are active there are usually the ones who genuinely had the worst experience.
196.
by mrosett 7y ago
I think you underestimate the power of endorsements.
197.
by mrosett 7y ago
My point was that taxis should have been banned too.
198.
by mrosett 7y ago
I didn't realize that they allow taxis but not Uber/Lyft. How delightfully corrupt!
199.
by mrosett 7y ago
I have no doubt that this will be the messaging service that everyone coalesces on. Just like Allo before it. /s
200.
by mrosett 7y ago
I'm glad scraping isn't criminal. Applying the CFAA here is ridiculous. But saying LinkedIn can't put technical measures in place to prevent scraping seems like a huge stretch to me. Why should they have to pay server costs f
201.
by mrosett 7y ago
The integrations in Excel are actually very important for power users. There's a reason Thinkcell can charge a couple hundred dollars per user.
202.
by mrosett 7y ago
Doesn't mean it's not also a cryptocurrency :)
203.
by mrosett 7y ago
If you're going to be condescending, please actually engage with my point. I wasn't claiming that nobody pays for certification. I was specifically questioning why it's a government agency that they are paying. "Organic&
204.
by mrosett 7y ago
According to the article, there’s no way to distinguish organic grain from standard grain. So if by all accounts “organic” is a marketing ploy, why should the government spend money on an inspection program to facilitate that? Let the farme
205.
by mrosett 7y ago
Yeah, Ben is a big fan of Clayton Christensen. I doubt he would have written a post with that title if he didn't think Christensen got most things right.
206.
by mrosett 7y ago
I just want to add my voice to the long list of people saying that a) he was brilliant, and his work (particularly How Will You Measure Your Life) is worth reading and b) he was just a kind, decent human being. I met him once and his warmth
207.
by mrosett 7y ago
Not that I entirely agree with the parent, but as you said: > if one cannot make the payment, they are in trouble. That's a function of cost of borrowing, not the amount borrowed.
208.
by mrosett 7y ago
I respect your creed, but I'm not religious so I don't think I'll adopt it.
209.
by mrosett 7y ago
Absolutely. They mention immunotherapy in the article, and pembro (aka Keytruda) is the best-selling drug in that class. Another big one that was introduced around the same time is nivolumab (aka Opdivo). Immunotherapy has really transforme
210.
by mrosett 7y ago
Ha - I read the cruise ship essay on the flight home a very miserable week at Disney World and it was exactly what I wanted. But that was a while ago; skimming it now it doesn't seem to have aged well.

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