mjewkes

5 ms·

1.
by mjewkes 5mo ago
>an awful lot of modern professional life consists of producing artifacts whose primary audience is other people producing artifacts. Slide decks for slide decks, strategy documents about strategy documents This is because thinking, comm
2.
by mjewkes 2y ago
Sure, they can build it here—but protectionism doesn’t deliver long-term success. In the short term, it drives up prices and makes consumers poorer. In the long run, tariffs shield companies from global competition and limit their ability t
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by mjewkes 2y ago
How do you get 55%? Wikipedia says 49.8%. https://en.wikipedia.org/wiki/2024_United_States_presidentia...
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by mjewkes 2y ago
CAR-T may have a ~50% cure rate for blood cancers: https://ashpublications.org/blood/article/141/19/2307/494672...
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by mjewkes 2y ago
I agree completely with the first part. But SWA-1380 was a commercial operating fatality in 2018. Not a crash into terrain, but the engine definitely crashed into the fuselage.
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by mjewkes 2y ago
Centrifugal forces on the spinning object will tear it apart once it goes “really fast”
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by mjewkes 2y ago
The FDA approves new modalities that do things “in their own way” all of the time! Yescarta, Kymriah, the mRNA vaccines, the approved VHH, scVF and “mimetics” in the article. Here’s a whole page of cell/gene therapies, many of these we
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by mjewkes 2y ago
>I can say this with pretty strong confidence: had the FDA not being so strict about its trials, lots of these experimental type of antibodies would have already received massived research and commercialization If the FDA was not so stri
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by mjewkes 2y ago
If you are truly netflix-to-be, you should be able to affordably incentivize your 12 key employees with equity. An exit for Employee < 50 at a netflix-to be will be in the hundreds of millions.
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by mjewkes 2y ago
Apples are better than bananas. Cherries are worse than apples. Are cherries better than bananas? -- GPT-4 - wrong gpt2-chatbot - wrong Claude 3 Opus - correct
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by mjewkes 2y ago
Notably, if you ask it to transform the statements to formal logic, you get a correct response! This stuff is truly magic. https://chat.openai.com/share/81e45fef-a72b-4258-98d6-5c8190...
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by mjewkes 2y ago
For sure. It's not a fair prompt at all. I'm super bullish on LLMs and am using GPT-4 in production right now. This stuff is magic. It's actually hard to find short, simple, "plain english" failure cases like the ab
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by mjewkes 2y ago
My current favorite “LLM breaker” below. GPT4, Claude, and this all fail. —- Apples are better than bananas. Cherries are worse than apples. Are cherries better than bananas?
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by mjewkes 3y ago
Editorial write-up: https://archive.ph/0T2XI
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The Economist's Ukraine war-fire model(github.com)
2 points by mjewkes 3y ago|1 comments
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by mjewkes 3y ago
Worth checking out the talk page. Looks like this whole article is out of date and that much of the problem is resolved.
17.
by mjewkes 4y ago
This seems credible: https://ascopubs.org/doi/full/10.1200/EDBK_288015
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by mjewkes 4y ago
As fabiancook mentions, credible sources all end up on pubmed within a year or two of publication, so it's an excellent resource. That said, Pubmed is an aggregator, not a curator. So you'll find a fair amount of crap there too. A
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by mjewkes 4y ago
https://www.rand.org/pubs/research_briefs/RB9412.html and The Great American Drug Deal, by Peter Kolchinsky. Specific claims: - The US pays more for new drugs than the rest of the world - The US contribution is di
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by mjewkes 4y ago
No assumptions. The rand article addresses that directly.
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by mjewkes 4y ago
Hey biorach - I would suggest: https://www.rand.org/pubs/research_briefs/RB9412.html and The Great American Drug Deal, by Peter Kolchinsky. Specific claims: - The US pays more for new drugs than the rest of the w
22.
by mjewkes 4y ago
The claim is largely true for drug development, but not for routine procedures. Those are expensive for unrelated, and largely pathological, reasons. I would suggest: https://www.rand.org/pubs/research_briefs/RB941
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by mjewkes 4y ago
The claim is largely true for drug development, but not for routine procedures. Those are expensive for unrelated, and largely pathological, reasons.
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by mjewkes 4y ago
I work in the drug development industry, its a shame this has been downvoted, it's largely true - at least for new drug innovation. The fact that routine procedures are expensive in the US is unrelated. The US is ~35% of the global pha
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by mjewkes 4y ago
>Do you have any data to backup your claim? I would suggest The Great American Drug Deal, by Peter Kolchinsky. Also - https://www.rand.org/pubs/research_briefs/RB9412.html >For example Cuban healthcare/
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by mjewkes 5y ago
Does anyone here recommend a modern-ish guide to GRF/settings/Gamescripts? It seems like there are so many features like CargoDist/FIRS/City growth - many of which are "essential", but don't play well toge
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by mjewkes 5y ago
Exact phrase matching is what google (sometimes? used to?) do for you if you put your search terms in double "full quotes". It returns only results that contain the exact multi word sequence in exactly the same order.
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by mjewkes 5y ago
ILIKE itself is a linear scan. The only way to index them are trigram indicies, which are very inefficient (and sometimes not usable) if you're searching document-length content. Whether or not it works in your specific situation depen
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by mjewkes 5y ago
Try https://simonwillison.net/search/?q=%22your+own+benchmarks%2... Looks like we get 37 results, of which 2 are true positives. Looks like "your" and "own" are both contained in the english.stop st
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by mjewkes 5y ago
Exact phrase matching. This generally requires falling back to ILIKE, which is not performant.

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