michaericalribo

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by michaericalribo 4y ago
No doubt. But It’ll be a more favorable comparison to you if you are focused on achieving your manager’s expectations, and proactively contributing to the larger org — not comparing yourself to others as your personal performance metric. It
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by michaericalribo 4y ago
Later: > Variants (SNP/ InDel) generated with this method were compared with a normal dataset using Archer’s analysis pipeline to distinguish noise from a true call. The normal dataset was created with sequencing data from seven you
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by michaericalribo 4y ago
No reasonable person reads “found genetic mutations in every astronaut” to plausibly mean “found bog standard genetic mutations everyone’s got.” This is pop science communication—journalism—not the actual scientific study. The goal isn’t sc
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by michaericalribo 4y ago
You’re eliding an entire body of research with “>2% of something.” That assertion is cited, and links to a full study. This is an observational study, and you may be analyzing it as a designed one. There was no randomization, no large sc
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by michaericalribo 4y ago
Maybe the scientists manufactured the data with CRISPR. /s In seriousness, we can come up with lots of out-there scenarios. But this finding is intrinsically interesting enough to warrant discussion, critique, and further analysis. You
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by michaericalribo 4y ago
I agree; that is basically my take, with two slight amendments: I didn’t have the sense there was a value judgement (more/less severe), so much as that CHIP is “typical” mutation seen in the wider population, associated with aging (its
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by michaericalribo 4y ago
I mean, yes, sunburn is excess ultraviolet radiation, but there are lots of other (more severe) forms and it’s pretty straightforward to understand they mean “excess [beyond the type experienced in the comparison populations, namely, the ge
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by michaericalribo 4y ago
I’m confused…did you read the Science paper itself? In their _first paragraph_ they reference baseline genetic variation, and age-related mutation versus the mutations seen in cancer survivors and—as it turns out—astronauts, in the second p
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by michaericalribo 4y ago
And hey if it’s pleasing to the ear do I even care?
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by michaericalribo 4y ago
Your memories of Adal seem unreliable Are you sure you are remembering correctly is it possible it was a different name There Is No Musician Named Adal I’m sorry your query “Adal” did not return any hits The name Adal is invalid please re-e
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by michaericalribo 4y ago
Farewell to Arms by Hemingway. I didn’t set out to read it, it just happened to be in the car I was driving. The plot is straightforward and the dialogue clear; but the story is powerful. Not something I’d’ve read on paper but I’m glad I di
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by michaericalribo 4y ago
This reads like a marketing presentation to spur user adoption. Since WA was released I’ve found it befuddling. It’s clever and cool…but what do I use it for? I see the same problem here: lots of solutions (hook in your web app! Ask questio
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by michaericalribo 4y ago
A weird little section in the talk page: > What's the deal with there being a million edits on this page in one day? > Articles get edited a lot, for all kinds of reasons… The fact that a page is being edited doesn't itself
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by michaericalribo 4y ago
Press and hold back on iOS to choose the page to return to
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by michaericalribo 4y ago
But to add my own, more substantive comment: I do have an intense hate of crypto. Not sure why you want to ignore tulips — speculative financial instruments seem like a very valuable comparison to crypto… For my part, I object to (a) the sh
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by michaericalribo 4y ago
This is not a constructive contribution and is addressed in the HN Guidelines: > Please don't comment about the voting on comments. It never does any good, and it makes boring reading
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by michaericalribo 4y ago
I think that ship sailed a long time ago…this may be a symptom but is definitely not the cause for fragmentation along ideological lines.
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by michaericalribo 4y ago
Much like Kim Stanley Robinson anticipated in the Mars trilogy.
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by michaericalribo 4y ago
For those interested in a more detailed history of the roguelike genre, I can’t recommend enough David Craddock’s book Dungeon Hacks: How NetHack, Angband, and Other Roguelikes Changed the Course of Video Games. It’s a really neat delve int
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by michaericalribo 4y ago
Disagreed. These are the end goals, but the very first step is to write as many words as possible. Editing is cutting what's there to something that actually works -- cleaning up.
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by michaericalribo 4y ago
A different take, but I use Freedom.io to block social media sites except for short periods during the day...it helps me both reclaim time that I would otherwise spend endlessly scrolling through garbage, and it makes the less frequent visi
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by michaericalribo 4y ago
I’d pay all my money for my mom not to be dead.
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by michaericalribo 4y ago
R itself was first released in 1993, and is based on S / S-Plus which date to the 70s...moreover, these have been standard tools since the 80s at least, well before Gretl...
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by michaericalribo 4y ago
In context, it’s pretty unambiguous he’s uncomfortable and doesn’t think it was an excellent experience
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by michaericalribo 4y ago
The language is a bit glib / inappropriate for something like depression. But behavioral training like this (I commented elsewhere abt it) can be successful even for people experiencing acute, clinical mental health problems. Those tec
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by michaericalribo 4y ago
Despite the way this is presented as a productivity / life hack, the broad principles are backed by good science. Specifically, the process of positive reinforcement and challenging assumptions is a cornerstone of Cognitive Behavioral
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by michaericalribo 5y ago
Good point! “Experiment” was probably a bad word to use. It’s important to work with a medical doctor, preferably a psychiatrist, to try any sort of pharmaceutical solution like SSRIs. They can offer professional guidance and informed super
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by michaericalribo 5y ago
OP’s comment was a bit flippant, but I interpret it as encouragement to try something new, and reassurance that it’s not as bad as you fear—someone else’s anecdata that the billion stupid reasons your brain generates aren’t valid signal for
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by michaericalribo 5y ago
I take Wellbutrin. It came after a long string of SSRIs, and I take it with Effexor (an SSRI) to manage obsessional symptoms. The side effects of Wellbutrin are on average lesser than SSRIs, but be aware / mindful that SSRIs are a very
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by michaericalribo 5y ago
One thing to highlight: there's no "beating" depression--setting that as the goal will be discouraging. But as you alluded to, there are ways to cope, and to manage it, and to live a good + fulfilling life in spite of the dep

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