m-ee

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241.
by m-ee 6y ago
I recently started contracting for a consulting shop I had a relationship with, took some back and forth to get them to agree to $100/hr and I felt pretty good about it. Then I got placed a project for a FAANG client where I'm the
242.
by m-ee 6y ago
In theory nothing, in reality a head start counts for a lot. I’m sure companies like Apple and Sony would love to stop paying Immersion exorbitant license fees for the privilege of making things vibrate, but they’re still doing it.
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by m-ee 6y ago
You can also make things tough on competitors by filing a new patent that’s different enough from the original to get approved, but close enough to the original that it would be difficult to use the older patent without infringing on the ne
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by m-ee 6y ago
Be careful, a lot of the “uncured” or “no added nitrites” have fine print that say “except those found in celery salt”, which is a natural source of nitrites
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by m-ee 6y ago
You can actually do much worse than nothing with antibody dependent enhancement. Let's say you make something that at first glance appears similar to the virus but is a little off. Maybe you chose the wrong proteins, or maybe you used
246.
by m-ee 6y ago
The goal of the vaccine is to train the immune system to recognize the real virus when it shows up. If you get it wrong, the vaccine may not simulate the virus very accurately which can lead to a number of issues. You may not mount an immun
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by m-ee 6y ago
Wage theft is by far the largest source of theft by dollar amount in America
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by m-ee 6y ago
This already exists, it’s called BARDA
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by m-ee 6y ago
Moderna and Pfizer/Biontech did not do regular screening to check for asymptomatic cases, aside from some samples taken in between the shots. Oxford/AZ did regularly screen some participants, but the primary efficacy analysis only
250.
by m-ee 6y ago
A subset of people in the AZ study were tested weekly. However the primary endpoint was prevention of symptomatic disease. For someone to count in the top line efficacy number they would have to show symptoms and test positive on PCR. This
251.
by m-ee 6y ago
You’re absolutely right, but I didn’t want the overall message to get lost in the details. I’ve been seeing people parrot the “AZ is actually much better than it looks because they included asymptomatic patients” for months now and it’s jus
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by m-ee 6y ago
The half dose and longer time efficacy numbers have confidence intervals around 50-60% wide, definitely need to do more testing on that. I agree its the biggest question to answer for them (aside from just getting cleaner data through the U
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by m-ee 6y ago
If they didn't have symptoms, they weren't counted in the headline efficacy numbers we're talking about. "The primary outcome was virologically confirmed, symptomatic COVID-19, defined as a NAAT-positive swab combined wi
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by m-ee 6y ago
This hasn't been tested but there's little reason to think this would be an issue. If anything having two different vaccines might be an advantage.
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by m-ee 6y ago
They do not have different measures of eficacy. AZ did more testing to look at symptomatic infections but that was not used in the primary efficacy calculation. https://www.thelancet.com/journals/lancet/article&#x2
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by m-ee 6y ago
This does not mean that this is reflected in the efficacy numbers. Read the paper and protocols they very clearly specify symptomatic disease confirmed with PCR.
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by m-ee 6y ago
It's quite literally one of the first things mentioned in the trial protocols and journal articles https://clinicaltrials.gov/ct2/show/NCT04516746 "The efficacy of 2 IM doses of AZD1222 compared to place
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by m-ee 6y ago
They did do more PCR but that isn’t reflected in the efficacy numbers. The end point for all trials has been prevention of symptomatic disease.
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by m-ee 6y ago
This presupposes that this tracking heavy targeted advertising has positive ROI for these small businesses. Is there any evidence this is actually true?
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by m-ee 6y ago
Harder to use the grandfather clock to signify your wealth when out and about
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by m-ee 6y ago
I agree that it was a dog whistle, less sure about the “just regular guys” part of Uber and Lyft. One of the reasons I used the services when they came out was that my driver was likely to be a local who generally knew where things were, bu
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by m-ee 6y ago
A friend worked on a blender. The wattage number was derived from the inrush current when first turned on.
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by m-ee 6y ago
I think those average numbers get skewed by expensive SUVs and luxury cars. You don’t need to spend $30k to get something decent and new, I think my Mazda 3 was like $17k in 2016. I think we’ll need a combo of good used prices like you ment
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by m-ee 6y ago
This was how we graded exams when I was a TA. Graders were assigned a specific question and would pass it off to the next station when done.
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by m-ee 6y ago
They’ve been getting injured at a higher rate since Amazon introduced robots to the warehouses and Amazon tries to limit their access to healthcare to avoid workers comp claims. This is definitely something a union would address.
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by m-ee 6y ago
Box seems to be taking some of the enterprise market share.
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by m-ee 6y ago
Not a virologist so I might butcher the explanation, but I think the strategy for universal flu is to target the “stalk” part of the virus since it’s similar across strains. We currently target the surface proteins since it’s easier to make
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by m-ee 6y ago
Some more detail in this article from July, they’re using mRNA to make the body produce virus like particles https://www.aidsmap.com/news/jul-2020/novel-vaccine-induces-...
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by m-ee 6y ago
I wish all drivers were written. Aside from things like arduino/pyboard the choice in my experience has been using some massively bloated questionably tested vendor code or just going to the data sheet and writing it yourself.
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by m-ee 6y ago
NIH is working on it, but it’s taking a backseat to covid

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