lysozyme

9 ms·

61.
by lysozyme 4y ago
That’s true, software for biology tends to be terribly, almost comically bad, with one-off file formats, brittle data interchange, and impossible-to-maintain code being the norm. With user interface and ergonomics being the most neglected a
62.
by lysozyme 4y ago
I’ve tried a lot of ad blockers over the years. Browsing mainstream news on the internet, in particular, highlights the absolute cesspool of pop ups and auto-playing videos that characterize the contemporary web. None, least of all Stop the
63.
by lysozyme 4y ago
There are many different types of plastic and they have surprisingly different molecular structures. Enzymes are remarkably specific catalysts, so an enzyme that eats PET [1] can’t eat another type of plastic, like HDPE [2]. So one solution
64.
by lysozyme 4y ago
In terms of the enzyme engineering challenge, it turns out to have been pretty straightforward to improve upon the starting enzyme. The designed enzyme sequence >contains five mutations compared to wild-type [1] In this case, the enzyme
65.
by lysozyme 5y ago
The technique used here to get pictures of the folded proteins (cryo-electron microscopy, or cryo-EM) has seen steady improvements over the past couple of decades. [1] It’s analogous to room temperature light microscopy like you might have
66.
How to become a tidy cook(clrcrl.notion.site)
3 points by lysozyme 5y ago|0 comments
67.
by lysozyme 5y ago
Thank you for posting this link. The video does a very good job of connecting the molecular details (even down to the geometry of a transition state structure) to the macro-scale movements of ATP synthase
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by lysozyme 5y ago
Myosin is a very cool protein because it’s a physical and direct link between the microscopic world of atoms and electrical charges and the macroscopic world of moving bodies. How myosin and other protein machines work at the atomic level i
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by lysozyme 5y ago
This tracks with your comment history https://news.ycombinator.com/item?id=567736
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by lysozyme 5y ago
Facebook may bring “a lot of good to the world”, but it brings a lot of bad, too. Is it worth the tradeoff?
71.
Could a Neuroscientist Understand a Microprocessor?(journals.plos.org)
2 points by lysozyme 5y ago|1 comments
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by lysozyme 5y ago
The strain of rat used in these experiments, the Sprague Dawley, is commonly used to study cancer because it has a higher baseline incidence of cancer and grows solid tumors faster than other strains [1]. Interestingly, it’s the same strain
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by lysozyme 5y ago
A related work, “MSA Transformer” [1], contrasts the strengths and weaknesses of language models using single sequences as input (as here) against language models using alignments as input. The authors of “MSA Transformer” perform ablation
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by lysozyme 5y ago
That’s a really interesting way of looking at the difficulty of the problem that’s being solved. I’m curious, how do you arrive at the number 10^9?
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Short fast history of protein design(bioinfo.rpi.edu)
2 points by lysozyme 5y ago|0 comments
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by lysozyme 5y ago
Pretty cool to see the success of PacBio (Pacific Biosciences) technology for long-read sequencing. PacBio is one of the few successful sequencing technologies using nature’s canonical high-fidelity DNA reading tool (DNA polymerase). Other
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by lysozyme 5y ago
If we say it’s nine rolls of two dice, and the probability of getting any particular pair of numbers in each roll is 1/36 (underestimate since we sometimes only care about the sum), then getting any specified sequence would be like (1&
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Ginkgo Bioworks S-4(sec.gov)
1 points by lysozyme 5y ago|0 comments
79.
Your problem with Vim is that you don’t grok vi(stackoverflow.com)
51 points by lysozyme 5y ago|4 comments