In terms of the enzyme engineering challenge, it turns out to have been pretty straightforward to improve upon the starting enzyme. The designed enzyme sequenc

In terms of the enzyme engineering challenge, it turns out to have been pretty straightforward to improve upon the starting enzyme. The designed enzyme sequence >contains five mutations compared to wild-type [1] In this case, the enzyme used as the starting point for engineering turns out to need only a few small changes to improve its ability to efficiently depolymerize PET. Choosing which of those small changes to make is the aim of the machine learning algorithms the authors used. The authors provide a visualization of exactly where those changes are inside the protein on their website >Interactive visualizations of MutCompute for Fig. 1 are available at https://www.mutcompute.com/petase/5xjh https://www.mutcompute.com/petase/5xjh and https://www.mutcompute.com/petase/6ij6 https://www.mutcompute.com/petase/6ij6 1. https://www.nature.com/articles/s41586-022-04599-z https://www.nature.com/articles/s41586-022-04599-z