koeng

12 ms·

91.
by koeng 2y ago
That’s not true. Here is a go playground of pretty much that exact code running just fine https://go.dev/play/p/v7OM9s_pRqY
92.
by koeng 2y ago
It’s hard to see how it would be evidence based if the evidence’s premise is fundamentally flawed - just in such a niche way that people not in my field wouldn’t be able to see it. They’re kinda preying on the fact that people like you can’
93.
by koeng 2y ago
No. But I feel like it is unlikely I'll find much value in it. Part 1 being on the Venter work does NOT inspire confidence at all. Not to dismiss them - they're great I've worked with them on a couple projects - but it frankl
94.
by koeng 2y ago
There was an RNA molecule or molecules that could make more of themselves (probably really poorly, at first)
95.
by koeng 2y ago
> where random gene modifications are just not probable enough to drive evolution. 3 billion DNA pairs cannot evolve randomly, there is not enough time and matter in the universe to randomly try successful generations of life forms. As a
96.
by koeng 2y ago
I'd love to see some benchmarks on your fastmath package
97.
by koeng 2y ago
Teal can't be total. The generics can get real annoying, I noticed. Still, was worthwhile to use for the most part.
98.
by koeng 2y ago
I've had very good experiences with swing dancing. People are so nice (LindyGroove in Pasadena). No pressure, and everyone is very accommodating to newbies. I'm not sure why, but there is a very high percentage of engineers.
99.
by koeng 2y ago
Eh, I think I disagree with this. The point is that I can make very complicated libraries in Teal, and those compile down and are usable in lua scripts. This is where I actually used it - very simple scripts, very large and complicated libr
100.
by koeng 2y ago
Nope, you can embed it. Teal is written in teal, and compiles down to lua - so you can simply put teal as a lua dependency. I used it with gopher-lua (Golang lua environment). https://github.com/teal-language/tl/pu
101.
by koeng 2y ago
I’m learning swing dancing. It’s been humbling. It’s humbling because all my life, I’ve been really good at technology - I specialize in biotechnology and manipulating DNA, but am also fluent in programming (mainly python, go, lua) and am a
102.
by koeng 2y ago
I’ve used teal before, the statically typed Lua that is mentioned at the end. It’s actually really good! There are some limitations (especially around generics) that can be annoying, however. Overall, I really enjoyed using it and would use
103.
by koeng 2y ago
Testing Elicit gave me quite a bit worse results than using PaperQA by futurehouse. While paperqa could understand a bit of the nuance of a scientific query, elicit did not. Too bad the internal paperqa system at scihouse isn't availab
104.
by koeng 2y ago
I got a tube of this probiotic. They asked me not to sequence it, but I'm a little suspicious of putting it in myself, so trust-but-verify (probably Nanoporing). I literally cannot see why sequencing it is a "dick move", so I
105.
by koeng 2y ago
Definitely interested in this for your wasm Go bindings!
106.
by koeng 2y ago
Hmmmm, I don't know if I buy their claim of primary endosymbiosis being so rare. Almost all insects have heritable endosymbionts. https://doi.org/10.3389/fphys.2013.00046
107.
by koeng 3y ago
What is the search engine that it uses?
108.
by koeng 3y ago
The reasons I ask for a counter example is because the number of “what ifs” are pretty much unlimited and easy to come up with, whereas I have to do a lot more thinking to answer them. It’s asymmetric and gets tiring Answer is: no, not prov
109.
by koeng 3y ago
can you give a specific instance of a sequence that would be dangerous in a cloning strain and not screenable?
110.
by koeng 3y ago
Thanks!
111.
by koeng 3y ago
Personally, I think the threat from the biologics itself is a little overstated. If COVID was released from a lab (I think it was natural), it was most likely due to bad governance and management of the lab. For DIY things - most DNA can be
112.
by koeng 3y ago
The oldest sequenced DNA is 1.6 million years old. In the right conditions, it lasts far longer than pretty much any storage method right now. Plus I also sometimes store things in Bacillus subtilis, which is very hardy https://k
113.
by koeng 3y ago
No, I know pretty much everything I synthesize. Once I don't, I'll just connect some screening software.
114.
by koeng 3y ago
I sometimes derive protocols from off-shelf ones, but pretty much everything beyond that is in-house. Most off-shelf protocols work for 1 sample in 1 tube - I had to adapt them to working on 1 plate of 384 tubes (and get those to work with
115.
by koeng 3y ago
A bespoke freelance industrial adhesive maker sounds like such a niche job, that's awesome. I would love to see a hackernews-type post with details of how he thinks about making a specific adhesive.
116.
by koeng 3y ago
I never went to university or anything, but did work for 4 years at UCI in directed evolution / mitochondrial engineering, then 3 years at Stanford on the FreeGenes project (got invited to work at both). Barely passed high school cause
117.
by koeng 3y ago
I use restriction enzymes + ligase to cut DNA, then paste it back together at specific sequences. It's pretty simple honestly! https://www.khanacademy.org/science/ap-biology/gene-expressi... The key is doing
118.
by koeng 3y ago
I found a virology textbook at the local Catholic book fair when I was in 6th grade, got hooked, teacher in 7th grade let me order GFP transformation kits to the school that I could do at home, then off to the races from there. I was in thi
119.
by koeng 3y ago
That's how Twist/Agilent do oligo pool synthesis (and Dynegene now). I'm pretty interested in the Genscript / Avery digital method of electrochemical synthesis. Turns out those pools ain't good enough to be used in
120.
by koeng 3y ago
I can share a few things! (but definitely not all) - One is finding different T7 RNA polymerases with unique properties by manipulating the backbone. They can be used for things like in-vitro RNA production for vaccines - Another is synthes

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