klmr

42 ms·

391.
by klmr 8y ago
Original paper: https://www.nature.com/articles/s41557-018-0046-3 Full text PDF: https://paperpile.com/app/p/ce9c364d-416a-0ede-9233-adf31910...
392.
by klmr 8y ago
> The DNA is changing real-time We already knew this. DNA is a highly dynamic molecule, and it’s changing constantly, as it’s involved in biochemical processes in the cell. i-motifs aren’t special or new in this sense.
393.
by klmr 8y ago
> 2 - If so, could the use of CRISPR be premature, if not dangerous? This is really an ill-posed question. First off, CRISPR is a tool. Its novelty is the fact that it makes an experiment vastly simpler and more reliable — but, fundament
394.
by klmr 8y ago
> The book was printed with wide outer margins and very narrow inner margins. The typical rule is to have the inner margins that are half as wide as the outer margins, so that the two inner margins, being adjacent, visually add up to the
395.
by klmr 9y ago
That’s plausible but it turns out not to be true. Disk read latency is larger than the overhead of our decompression, even on fast storage media. As a consequence, better compression actually leads to (slight) performance improvements. Addi
396.
by klmr 9y ago
That’s why compression of sequencing data is becoming so important. CRAM is nowhere near the theoretical limit (CRAM achieves ~2x over BAM; commercial products currently achieve up to 6x). (COI disclaimer: I work for such a company.)
397.
by klmr 9y ago
Their 40% number comes from the paper I referenced (i.e. that’s the one the Darwin paper references). I completely agree with your point 2. I’m not sure I agree with your first point: I think it’s pretty reasonable for it to have been publi
398.
by klmr 9y ago
> I don't really know what to make of the idea that it "has been discredited as a pseudoscience by experts" The Wikipedia article actually does a fairly good job of listing the evidence for this claim (further down). In pa
399.
by klmr 9y ago
> The long read technology comes with a drawback though – high error rates in sequencing of between 15%-40% These error rate estimates are seriously outdated (the quoted number is from a 2015 paper but it was obsolete pretty much as so
400.
by klmr 9y ago
No, a given assembly is easy to verify. The complexity in actual application comes from the fact that performing the sequencing part (the biological/mechanical part) again will yield a different assembly due to biological and technical
401.
by klmr 9y ago
The original Packrat parser explicitly defines it as using memoisation : > Packrat parsing provides the simplicity, elegance, and generality of the backtracking model, but eliminates the risk of super-linear parse time, by saving all in
402.
by klmr 9y ago
> What kind of PEG are you talking about? I’m talking about the Packrat algorithm which, as far as I know, is the only practically used PEG algorithm. The memory requirement comes from the fact that the algorithm handles partial match fa
403.
by klmr 9y ago
> The article says that PEG handles non-deterministic grammars by becoming non-deterministic itself. Wait, where? As noted here, PEGs are certainly deterministic, so I just double-checked the article: it doesn’t claim that PEGs are non-d
404.
by klmr 9y ago
As far as I understand (I haven’t lived in France since 2004), the import and export restrictions are essentially unenforced, and nobody cares (as long as you’re not actively trading with embargoed nations). But if you’re working in cryptog
405.
by klmr 9y ago
There is no paradox: Plastics have really only been around for less than a century. Modern plastics are all synthetic, and sufficiently distinct to all naturally occurring biopolymers. So bacteria only had ~100 years to evolve this capabili
406.
by klmr 9y ago
> But structurally that's about the only thing they have in common. Sure, but it’s — at least in principle — enough: the whole point of my answer was to highlight that the same fundamental catalytic reaction can attack the bonds of
407.
by klmr 9y ago
It’s not quite the same though because all/most plastics are relatively simple organic polymers that have similarities in their chemical structure, which might in principle be exploited by an enzyme (or, more realistically, a class of
408.
by klmr 9y ago
> Wasn't PGP illegal in France in the 1990s? Essentially yes (and not just PGP), strong cryptography fell under arms regulations and required, essentially, the equivalent of a firearms license (but was, by contrast, almost impossibl
409.
by klmr 9y ago
The computer science formalisation of these operations is known as “relational algebra”, which is based on set algebra. That said, the assertion that all elements in a set be equal doesn’t really make sense — or rather, it’d be written as “
410.
by klmr 9y ago
As an aside: > (overly processed and HFCS added) Orange Juice In Europe and the US this can’t be sold as “fruit juice”. The regulations are as strict as they are clear: “juice” can’t have sugar or HFCS additives, it must be 100% fruit, a
411.
by klmr 9y ago
Fair enough, everything in moderation. Two litres strikes me as truly exceptional. That said, even that amount probably doesn’t have averse long term health effects if you ensure sufficient water and electrolyte uptake to offset its diureti
412.
by klmr 9y ago
If you’re refusing to hire men this would be illegal. If you hire men but pay them only 90% of their market value, then your company will be known as not paying competitive salaries and won’t attract candidates (not just men — any job app
413.
by klmr 9y ago
> these days most workplaces have a strict no-alcohol policy I’d be curious where you’re working because this definitely isn’t true in the UK (Friday afternoon pints at work are customary), nor in France (most canteens stock wine for lun
414.
by klmr 9y ago
> it's quite accepted to mandate your day with a high volume of coffee, cigarettes then cool down with alcohol One of these things is not like the other: Consuming even high volumes of coffee isn’t only completely safe, it probably
415.
by klmr 9y ago
> but hey, oxygen use to be a toxin too. It still is. Oxidative stress is a major threat to cells. There’s a lot of expensive machinery to keep the damage in check but it’s not foolproof.
416.
by klmr 9y ago
Assuming you’re actually serious: Companies don’t pay men more, they pay women less — because they pay everyone as little as they can: it’s well established that women systematically under-estimate their own value, compared to equally-qua
417.
by klmr 9y ago
> The tie-breaker is financial. It can be both financial and social: individual institutes are all too happy to pay for Mathematica licenses, and consequently institute members can use it to produce reproducible research with it. However
418.
by klmr 9y ago
By contrast, I found that my Facebook dump was extremely devoid of information. Sure, a few advertisers have my data (but much fewer than in the article, < 200!). Beyond that, the dump contains very little information that I didn’t expli
419.
by klmr 9y ago
There’s also the Ford Pinto. In Brazilian (!) Portuguese, “pinto” is close to the male equivalent of “cona”.
420.
by klmr 9y ago
> also can use = sometimes too (and I think has different semantics) That’s a common misconception (even the official documentation is misleading). In reality, assignment `<-` and assignment `=` have the exact same semantics (exce

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