jonlucc

7 ms·

31.
by jonlucc 2y ago
> Even Twitter was having problems Is that a surprise? They're not who I would think of first as a gold standard for high viewership live streams.
32.
by jonlucc 3y ago
I'm not sure how much I can say; I don't work for a CGM company, but my company is very interested in diabetes. There are non-device reasons you can't use a CGM indefinitely. The site becomes less reliable over time, and it v
33.
by jonlucc 3y ago
I'm not sure of the current progress, but I was at a conference a couple years ago, and the Dupixent folks were presenting. It was right after the approval for pediatric atopic derm, and they were hopeful that for people with severe al
34.
by jonlucc 3y ago
Most companies don't have 2.1M employees.
35.
by jonlucc 3y ago
At my work, there are certain areas that we are not allowed to have any cameras, and that includes all personal cell phones. I have a colleague whose daughter was at school during an active shooter incident, and she was able to use her phon
36.
by jonlucc 3y ago
I've worked on studies of mice that went to ISS. I understand the ethical concern. Ultimately, mice are used regularly as a model of human disease. The study I worked on specifically considered whether a particular treatment could help
37.
by jonlucc 3y ago
That is why doctors are supposed to consent their patients and weigh those risks. For what it’s worth, the risk of incontinence form prostate cancer surgery has been dropping quickly as traditional surgery is replaced by robotic surgery, sp
38.
by jonlucc 3y ago
At least in pre-clinical research, there’s also a mechanism by which regulatory agencies can sometimes force industry to pay for replication studies. It’s a little complicated, because sometimes there aren’t many groups who can reliably do
39.
by jonlucc 3y ago
Completely anecdotally, I find this to be true. I do pre-clinical research (disclaimer: for a pharma company), and if you hand me a paper describing some research result in my field, it’s much more likely to reproduce in my hands if it’s fr
40.
by jonlucc 3y ago
Hank Green just posted a video about this recently, and he addresses this. In the past, helium was extracted alongside natural gas, but there is no reason the two need to be linked. As natural gas prices go down and helium prices go up, it
41.
by jonlucc 3y ago
Grimes isn't her given name. It's a chosen name, which is common in performers.
42.
by jonlucc 3y ago
I work in preclinical pharma research, so I have spent a good amount of time trying to recapitulate published data in animal models, so not quite clinical trial data. People who do this work learn how to evaluate trustworthiness. It can be
43.
by jonlucc 3y ago
Every clinical trial paper I've read has a discussion of inclusion and exclusion criteria. I think for the trial to be registered, it has to include this information.
44.
by jonlucc 3y ago
Why would the statisticians be anonymous? I'm aware of at least a couple cases in which an independent set of statisticians were provided the data from a clinical trial specifically for a re-analysis. In one case, they showed some pret
45.
by jonlucc 3y ago
I purchased hardware (a wheel), a new game, and started playing it because a streamer whose taste generally aligns with mine was playing that game this weekend. Then, I had him playing on one monitor while I played on the other. I don'
46.
by jonlucc 4y ago
While technically true, and is, in my opinion, one way to avoid jailing political enemies just to take them off the ballot, there's a reason candidates do a lot of rallies while they're campaigning. If a candidate is actually in j
47.
by jonlucc 4y ago
I know this isn't going to be the most popular solution, but I find that Twitch Turbo isn't much discussed. I think it's $8 and eliminates ads from all channels. It may make more sense financially for some viewers, but it doe
48.
by jonlucc 4y ago
All they have to do is allow sorting by total cost. It shows it on the search results, but will not allow you to sort by it.
49.
by jonlucc 4y ago
AirBnBs can have yards, kitchens, multiple bedrooms, and locations hotels don't exist. I think those are the main things that benefitted them as they grew, and that market is still largely only served by AirBnB and VRBO. I haven't
50.
by jonlucc 4y ago
Well based on their materials and methods, the antibiotics were all ordered from Sigma, which is not a pharma company, and I doubt they stand to gain much from the study. What kind of manufacture do you think benefits from this outcome?
51.
by jonlucc 4y ago
Honestly, for PCR, this is a larger N than I would guess is needed. In general, rats kept in constant conditions don't have a ton of variation, even in fairly high-sensitivity assays. I would expect a lot more samples if you were sampl
52.
by jonlucc 4y ago
I don't work with antibiotics or directly with the microbiome, but I have some questions about how these rats were housed. As background, I work in autoimmune pharma discovery, and my role is primarily with rodent models of disease. I
53.
by jonlucc 4y ago
Isn't that just a longer way to say that it's a shortage of pay rate, benefits, and willingness to train? If the market is booming, and pay rates haven't caught up, aren't they short?
54.
by jonlucc 4y ago
Just to add to this, the last thing that will be taken over by computers is tox testing. This is the last step that says "this drug is safe enough in primates to test in humans". It's the most complicated type of animal testi
55.
by jonlucc 4y ago
Short answer: we are. Clinical trials are expensive. NHP (Non-human primate) studies are also expensive, but orders of magnitude less expensive than human studies. We pharma researchers don't want to put stuff into humans if there&#x27
56.
by jonlucc 4y ago
Yes, alopecia areata is generally a progressive disease. It might be worth discussing with your doctor early. I'm not too familiar with the European regulatory landscape, but I would guess any JAK inhibitor would need to prove efficacy
57.
by jonlucc 4y ago
Practically, then, how do researchers access Elsevier articles? I work in big pharma, and if there's an article I don't have access to, I just request it through our information services office, and it is emailed to me almost inst
58.
by jonlucc 4y ago
> 3 or 4 12 hour shifts a week is normal for salaried nurses. $5200/wk isn't. It's over double. It's a normal shift schedule, and they pay travel nurses much more than staff nurses to work the same shift schedule. The
59.
by jonlucc 4y ago
Hospitals have been paying 4x staff rates for travel nurses for multiple years now, though.
60.
by jonlucc 4y ago
I replied to the parent, but the highest quotes are probably emergency contracts for 5 or 7 shifts of 12 hours but only for a week. Longer contracts are often 3 months at 3 or 4 shifts per week.

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