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Just to add to this, the last thing that will be taken over by computers is tox testing. This is the last step that says "this drug is safe enough in primates t
by jonlucc 4y ago
Just to add to this, the last thing that will be taken over by computers is tox testing. This is the last step that says "this drug is safe enough in primates to test in humans". It's the most complicated type of animal testing, because it is necessarily the interaction of every system in the body that could cause a tox issue.
So sure, we use modeling, and it's getting better, but it's not going to replace toxicology studies any time soon, unless every other human system is replicated in silico first.
- duckmysick 4y agoA comment by bsdz links a research paper and says that a computer model for cardiotoxicity has higher accuracy than animal models. The paper title mentions in silico as well. Are those the same things you're talking about or is there something I'm missing. I'm not that familiar with drug development. https://news.ycombinator.com/item?id=32048391 https://news.ycombinator.com/item?id=32048391
- oaktrout 4y agoThe paper linked by bsdz checks for one specific cardiac side effect, it is not anywhere close to being a model for cardiotoxicity as a whole, a very important distinction.
- duckmysick 4y agoOk, that makes sense. Is there a meta analysis of such models?
- oaktrout 4y agoI'm not sure tbh, this really isn't my area of expertise. Sorry, I was hopeful someone more knowledgeable would reply.