ishishah

8 ms·

1. 1.▲
   by ishishah 5y ago

   Thank you! Long way to go, but the ride is fun.
2. 2.▲
   by ishishah 5y ago

   Thank you for that advice. I will work on that.
3. 3.▲
   by ishishah 5y ago

   Hi! Pasteurization is not known to impact the structure or function of human milk oligosaccharides. But there are certain heat labile molecules that are impacted by it, and raw milk may retain those. But there is a whole another story with
4. 4.▲
   by ishishah 5y ago

   Great question: The goal is to dramatically slow down the process of resistance by choice of molecules that are rapid in activity, and creative compositions. Milk, as a whole will remain to be very effective, like it has been during the mil
5. 5.▲
   by ishishah 5y ago

   :-) Thanks!
6. 6.▲
   by ishishah 5y ago

   Thanks! And I hear you, and recurrent & the secondary infections and the cyclic nature of it all are terrifying, to say the least, and the truth is also that in many cases, the recurrence is due to resistant bugs, that are just not elim
7. 7.▲
   by ishishah 5y ago

   Thank you! Yes, absolutely. Some of our candidate peptides impact bacteria across the spectrum and we are in the process of evaluating effects on viruses, specifically because the vaginal infections predispose patients to other secondary vi
8. 8.▲
   by ishishah 5y ago

   Amen to that. Restoration of the gut microbiome is key to life-long health, starting with infancy, where colonization by the "right" beneficial bacteria is really important. Infact, milk does a remarkable job with that. One exampl
9. 9.▲
   by ishishah 5y ago

   Yep. For us, production and scaling is/will continue to be COMPLETELY independent of donor milk.
10. 10.▲
    by ishishah 5y ago

    Thank you for your comment. We are evaluating the best path forward based on safety dossier requirements for topical applications. Longer term, we envision that the product should be a prescription based. Re your comment about founders&#x27
11. 11.▲
    by ishishah 5y ago

    Thanks for your question. Our initial analysis was from a small batch of milk, separation from other components, and evaluating function. Subsequently, we have been getting them synthetically made, determining dose and therapeutic index, to
12. 12.▲
    by ishishah 5y ago

    Thanks! Yes, I imagine that any industry with higher requirement of resources and de-risking of technology walk hand in hand with challenges. Getting off the ground challenge #1 is When?, #2 Funds? and #3 Determining precise timing to get t
13. 13.▲
    by ishishah 5y ago

    Thank you! We are all excited.
14. 14.▲
    by ishishah 5y ago

    :-)
15. 15.▲
    Launch HN: Matrubials (YC S21) Milk-derived therapeutics for infectious diseases

    94 points by ishishah 5y ago|36 comments
16. 16.▲
    Milk-derived therapeutics for infectious diseases

    3 points by ishishah 5y ago|1 comments