i_love_limes

6 ms·

1.
by i_love_limes 2mo ago
That was kind of my initial point... there are far too many permutations that alter what you want to maximise to consider this as a good option right now. Environment, gene-environment interactions, epigenetics, polygenecity, pleiotropy, e
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by i_love_limes 2mo ago
Great question! It maybe can be, but what is the maxima that is being solved for exactly? There are usually tradeoffs, the most common and prevalent is our body's immune response. If it's under-active, we might die from an infe
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by i_love_limes 2mo ago
I think people in HN (and in general) have to remember the central axes of evolution before digesting this kind of article. I've already seen comments like it's "odd that no species has ended up evolving a continuous mainten
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by i_love_limes 4mo ago
This is a pretty egregious misreading of both Hardin and Ostrom, where on earth did you get this from? Hardin did not argue that private industry was more efficient. His paper described that with an unmanaged, private, unregulated open pas
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Wikipedia at 25: A Wake-Up Call(meta.wikimedia.org)
30 points by i_love_limes 9mo ago|3 comments
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by i_love_limes 1y ago
I have to disagree with your take on "High critic score / low audience score". There is a swathe of more challenging, experimental, or art house movies that fall into this category. These reviews fill the void where another
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AlphaGenome: AI for better understanding the genome(deepmind.google)
529 points by i_love_limes 1y ago|176 comments
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by i_love_limes 2y ago
The old hacker news hug of death...
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by i_love_limes 2y ago
Great idea! The scrolling is a bit broken though. I can't scroll down the text on my trackpad without it going to the next article, and also it just a lot of articles with a tiny movement of the trackpad. Otherwise it's a really
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by i_love_limes 2y ago
I'm having a hard time googling the book you mentioned. Is it by any chance called 'They Thought They Were Free: The Germans 1933-45'? That's the closest thing I could find. https://en.wikipedia.org/wik
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by i_love_limes 2y ago
Well no. It's not uncommon for p-values to be even lower than that. We are talking about a specific SNP (allele) having a specific mutation being predictive of a phenotype / outcome. So, a specific SNP mutation being predictive
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by i_love_limes 2y ago
So, it is like that, but it's also not. A couple decades ago, with the advent of GWASes, because of all the multiple testing that was going on, there was an agreed new p-value threshold p < 5e-8. This was to account for multiple t
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by i_love_limes 2y ago
I have never heard of FireDucks! I'm curious if anyone else here has used it. Polars is nice, but it's not totally compatible. It would be interesting how much faster it is for more complex calculations
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by i_love_limes 2y ago
Other high ranking military officers that have worked closely with Trump disagree. I might be inclined to believe them over you, unless you've also worked with Trump? Or are you just someone that he would call a 'sucker'?
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by i_love_limes 2y ago
I have a question that hopefully a molecular biologist can answer. Can tools like this potentially create protein structures that specifically bind in certain cells? Or is this more about a way of being able to create proteins for genes &
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by i_love_limes 2y ago
I suggest you read 'Study Size' under 'Methods'. Detecting an odds ratio of 1.3 with 80% power, and rounding way up to 3000 cases. To me that's not a small sample size, but definitely not the highest OR to aim for
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by i_love_limes 2y ago
You are trying to justify one strand of unethical behaviour (how humans have bred dogs) with another. Not sure that holds up.
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by i_love_limes 3y ago
For those not in Academia, it's worth noting that when you get to his level, it's more like being a VP or senior leader. Ultimately, yes you are responsible for the quality of output of your team, but you are absolutely not looki
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by i_love_limes 3y ago
I ran into this too. I run a very silly slack bot for my friends, and it randomly cycles through pictures that we all have created. Initially it was completely random choice per invocation. Had to change it to a randomly sorted list that
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by i_love_limes 3y ago
> Best Things First. By Bjorn Lomborg Wait, this is the social scientist who wrote The Skeptical Environmentalist, whom a Danish Science committee found to be "scientifically dishonest through misrepresentation of scientific facts,
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by i_love_limes 3y ago
A lot of people... in fact a huge portion of statisticians, epidemiologists, econometrics, use it as their primary language. I do genetic epidemiology (which is considerably more compute intensive than regular epidemiology), and R is still
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by i_love_limes 3y ago
In my field (genetic epidemiology), there are annoyingly un-standardised toolsets. There are libraries in R, python, and C/C++ binaries. Being able to string these together in one notebook is helpful. That being said, I usually just
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by i_love_limes 4y ago
So, this peer reviewed analysis of real data is wishful thinking science compared to your anecdotal observations? I might suggest you rethink your stance based on new information. It's also interesting, how if school didn't play
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by i_love_limes 4y ago
In 2015, GitHub sent me a DMCA takedown notice for a repository of dotfiles. When I tried to convince them how ridiculous that is, their only suggestion was to file a DMCA counter notice. Glad they've come a long way since then.
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by i_love_limes 4y ago
Is this a real opinion? My god. Thinking that aborting female embryos because they will be considered less important in society is wrong, AND think that removing a women's right to choose entirely based on religious teachings is wrong
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by i_love_limes 4y ago
This has garnered quite a lot of reactions from the comments. I'd like to ask a genuine question about this, from the perspective of assuming that Nature is acting in good faith about this. Let's say someone has calculated the po
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by i_love_limes 4y ago
This thread has quietened down now, so I'd like to ask about those forums you were talking about. I'm really curious about them and would love to have a closer look, but I completely understand if you don't want to divulge t
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by i_love_limes 4y ago
I'm sorry, but you did not dub the term toxic positivity.
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by i_love_limes 4y ago
Have to disagree on this one. Something as basic and out of the box as a migration / data backfill is not only complicated but also very expensive (both time and cost wise) on Dynamo. Not to mention all the other things that come nic
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by i_love_limes 4y ago
In the interview he seems to be more loose with his words, but that also doesn't say causation. In the paper the conclusion is "This study demonstrates that influenza vaccination is associated with reduced AD risk in a nationwide

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