haldujai

8 ms·

61.
by haldujai 2y ago
You’re missing that we have treatments with known risk/benefits vs research treatment X with undefined risk and reward. It’s extremely challenging if not impossible to obtain informed consent in this situation. We’ve been through this
62.
by haldujai 2y ago
It’s similar in both countries with some slight variation in the US depending on the state. Unless the prescription is marked as “do not substitute” pharmacists generally have the discretion to substitute for a generic, in fact a few states
63.
by haldujai 2y ago
Sexual dysfunction is a real, widespread disease . With that said, Viagra was initially developed for high blood pressure and chest pain. Testing didn’t pan out but it worked wonders for erections so it was rebranded. It is also used in pu
64.
by haldujai 2y ago
I think you’re conflating plastics with aesthetics/cosmo. Only a small minority of plastic surgeons practice primarily aesthetics. Majority will have a micro, breast or hand practice and have a side hustle in aesthetics so the overall
65.
by haldujai 3y ago
Perhaps I got lost but I am discussing your original statement of “using the patients' symptoms and objective data may actually outperform current medical standards” which relates to the model predictions/inference not training. I
66.
by haldujai 3y ago
> Plus, even for the cancers we do have screening for, it's often not frequent enough to catch more aggressive variants early - a lot of these screenings are only once every ~2-5 years. Screening intervals are based on doubling time
67.
by haldujai 3y ago
Inference on the validation set is xray -> pain score. It does not incorporate patient symptoms to make the prediction. In real life a surgeon incorporates the xray + patient symptoms/pain score.
68.
by haldujai 3y ago
Colonoscopy is confusing because it is both screening and diagnostic/investigating. Most if not all of the complication/risk (perforation and major bleeding being the ones of note) is from the polypectomy / biopsy part of the
69.
by haldujai 3y ago
The explainability/methodology is lauded. Not sure what a letter to the editor would accomplish. The nature paper only interpreted radiographs and the only claim of the authors was basically that the model is a better predictor of pain
70.
by haldujai 3y ago
> Sure, of course you would make practical decisions about what kinds of tests to administer, and not proactively administer the tests that have significant negative side effects. The harm is from investigating the screening test result
71.
by haldujai 3y ago
I don’t know about that, speaking to oncology as I work in a NCI designated cancer center (i.e. somewhere that spends dizzying amounts) and it skews younger than you might think these days. I’m not sure what you mean by “very, very few year
72.
by haldujai 3y ago
> Even though we know prognosis is much better for cancer, and many other diseases, if you catch it early, 5. Diagnosing cancer/disease early does not necessarily improve outcomes. https://en.wikipedia.org/wiki/
73.
by haldujai 3y ago
> It's a nice example of where using the patients' symptoms and objective data may actually outperform current medical standards I think you’re jumping the gun here, this paper was a hot topic when it was published. Patient sym
74.
by haldujai 3y ago
LLMs don’t have insight, these outputs cannot be assumed to be accurate. Due to current hardware limitations it is not feasible to have a 1T parameter model without MoE.
75.
by haldujai 3y ago
Thank you for adding adding that. I should have phrased it as: “it is permitted to not offer the futile intervention / heroic measure.” As an example this is typically something like not offering CPR when death is imminent for another
76.
by haldujai 3y ago
You wash, irrigate, and provide prophylactic antibiotics but shit happens, this was a very unfortunate case especially as there was no implant. Pseudomonas infections are rare in healthy patients and few antibiotics work.
77.
by haldujai 3y ago
The drying is probably the more effective part for mechanical disruption. Similarly why bleach wipes > soaking in bleach for disinfecting surfaces, as alluded to in this paper.
78.
by haldujai 3y ago
> Do you take issue with ... the idea that these were a gigantic leap? Yes, the gigantic leap was transformers. No one thought we peaked with 340M or 1.5B parameters, in fact expectations from early work was that massively scaling was go
79.
by haldujai 3y ago
It is not up to physicians to decide whether the resulting quality of life reduction and morbidity from heroic interventions is worth it for a patient. If the intervention is unequivocally futile for preserving life it is permitted to not o
80.
by haldujai 3y ago
This is a real life case. This article explores surface disinfection (commonly bleach in the hospital). Although provider gowns are removed after entering contaminated rooms, disinfected surfaces commonly come into contact with provider scr
81.
by haldujai 3y ago
Yes, the relevance is providers don’t change scrubs between patients (although do wear typically disposable gowns and gloves when entering a patient room with c. diff). Also relevant for things that travel between rooms and are disinfected
82.
by haldujai 3y ago
Glad to hear approval for vanco is relaxed, this was 2015 when I think vanco first line was still new. I was also on the university drug plan which required documented treatment failure at that time. I remember we used to give patients vanc
83.
by haldujai 3y ago
I wouldn’t jump to the conclusion that the fear is justified, not every broken bone is “simple” and while most fractures are nonoperative some do require surgical fixation. Pain reduction isn’t the main reason to operate or the metric of in
84.
by haldujai 3y ago
Not really because moral hazard occurs when you’re protected from consequences. Missing an early nosocomial infection means you’re now on the hook for very long admissions with expensive treatments and interventions. Personal experience in
85.
by haldujai 3y ago
It’s become a lot more accepted to wear scrubs in the US post-pandemic as well. Some places are still old fashioned though, I believe Mayo is still suit and tie.
86.
by haldujai 3y ago
Not sure about Canada anymore, Queens was doing this in select cases when I was there, but FMT is also increasingly used for initial episode fulminant CDI in the US as well (varies by institution). I was unlucky enough to get CDI in medical
87.
by haldujai 3y ago
I doubt it would be hard for Microsoft to rebuild, Microsoft Research has made many excellent contributions to transformers for many years now, DeepSpeed is a notable example. I don’t think they’ve had the will/need to have done this b
88.
by haldujai 3y ago
I believe his total comp since becoming CEO passed 1B this summer, 9 years or so.
89.
by haldujai 3y ago
As in liquidate a billion in one raise? Is that kosher these days?
90.
by haldujai 3y ago
I randomly chose 30% to represent a seemingly large non majority sample which may not be representative of the underlying population. I have no idea what the actual proportion is, nor how investors feel about this right now. The true propor

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