gwerbret

17 ms·

151.
by gwerbret 5y ago
I'm going to make what is probably a controversial statement, which is that, in my experience, most meta-analyses are trash. A meta-analysis is usually grounded on the assumption that an aggregation of multiple, well-conducted studies
152.
by gwerbret 5y ago
...in a heavy, almost incomprehensible (to his audience) southern accent.
153.
by gwerbret 5y ago
You make a very sound argument about the engineering perspective. Unfortunately, many of the folks writing such software aren't (formally-trained) engineers. Would you suggest that they receive training which allows them to think of so
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by gwerbret 5y ago
> You people have lost your minds...the vaccines are a poor risk proposition for huge segments of the population they're being administered to, and Covid is a virus on par with the 1968 influenza season whose threat is being vastly
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by gwerbret 5y ago
Hired goons?
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by gwerbret 5y ago
I'll rephrase the GP's question because I'm also curious, and I don't feel your response answered the question. Is there a signal which suggests that "public creativity" equals "good engineer", partic
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by gwerbret 5y ago
> And it's for excellence, not accidents. It so happens that many, many seminal discoveries in science are accidents. The discovery of the cosmic microwave background is probably one of the more popular examples of this, and certain
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by gwerbret 5y ago
As has been pointed out by others, there already exist databases that annotate many key metabolic pathways; however, I think the reason the database you describe doesn't exist is that there's a LOT more very customized work in rec
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by gwerbret 5y ago
This is probably the clearest example of rasengan's thought processes so far. It's remarkable how nothing he was told -- about why #python was moving, about what actually constitutes a "community" -- even registered, so
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The Lawnmower IRC Server(jotunheimr.idlerpg.net)
6 points by gwerbret 5y ago|0 comments
161.
by gwerbret 6y ago
Off topic, but the manner in which you and GP resolved your disagreement (with respect, active "listening", and acknowledgment of counterpoints) represents some of the very best of HN. It was a pleasure to see; thank you both.
162.
by gwerbret 6y ago
Indeed, as I wrote elsewhere. (I can't directly respond to your other comment, with which I also agree). But there are two relevant questions: first, does this constitute orthotopic neurogenesis in any meaningful way? The progenitors a
163.
by gwerbret 6y ago
This has been a topic of intensive research for several decades [0]. In a nutshell, people have looked, repeatedly, and have failed to find very much. There are two main stem cell populations in the brain, which produce new neurons in two d
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by gwerbret 6y ago
To return the goal posts to their original location, my premise was that the title "Parkinson's gene may impair how new neurons are made throughout our lifetime" is misleading, as the neurons in question are not actually made
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by gwerbret 6y ago
> demonstrating that this gene has an effect on neurogenesis of human dopaminergic neurons from the substantia nigra. But there is no neurogenesis of human dopaminergic neurons in the adult substantia nigra. To create the organoid mode
166.
by gwerbret 6y ago
They are misrepresenting the state of knowledge in that field. It has indeed been known -- since the 90s -- that there is ongoing neurogenesis in the human brain after birth. However, it is also well-known that these new neurons are produce
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by gwerbret 6y ago
"Parkinson's gene may impair how new neurons are made throughout our lifetime." This title is rather misleading, as the neurons relevant to Parkinson's disease are generally not made at all, after birth.
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by gwerbret 6y ago
In the example you gave, I have the opportunity to interact with this third party, demand to know why they're there, and may choose to leave, with my privacy intact, if I don't like their presence. This is all part of the process
169.
by gwerbret 6y ago
> I stopped caring if my students cheat a long time ago. It's not worth the hassle and it does lower my completion rate which is the only thing administration cares about. Cheating increases the passing rate so I'm all in favor
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by gwerbret 6y ago
This is also incorrect. "Prevention of disease" and "prevention of infection" are two related but clinically-distinct objectives for these vaccines. So far, early clinical trials were generally testing the first objectiv
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by gwerbret 6y ago
> What I hate when I'm reading these things is the colorful, biography-like nonsense that major publications (and self-important "journalists") like to toss into stories I've noticed that many supposedly serious, non-
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by gwerbret 6y ago
> I understand for pricing purposes we're on the higher end, as mentioned in the note, this is intentional to validate we provide enough value What exactly do you mean by "validate we provide enough value"?
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by gwerbret 6y ago
> I eventually decided I felt that way because he didn't make his expectations for me finishing and tailoring those expectations to my career goals clear up front, and very few advisors do so. I come at this from a different field (
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by gwerbret 6y ago
> You’re correct that a “dysfunctional society” failed this kid. But society that’s missing here is the society of people who are supposed to keep an eye on this kid. That social infrastructure has been destroyed—for a variety of reason
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by gwerbret 6y ago
> Electric passenger aircraft are not and will never be viable Why not? "Never" is a very significant word, but if you have sound reasons for using the word here, I'm genuinely interested in your thoughts on the matter.
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by gwerbret 6y ago
> There's a difference between a theory being untestable even in principle and being untestable because we have not yet understood the theory well enough. If the theory is neither testable nor verifiable, then how do you (or anyone
177.
by gwerbret 6y ago
This is a bit off-topic, and is probably a naïve question, so forgive me in advance for both. I've always been under the impression that "engineer" was a protected professional title, just like "medical doctor" or &
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by gwerbret 6y ago
> No to be clear I'm saying you are comparing things that are way more different than our friends at Cloudflare would like you to think. Care to expand on that? What exactly do you mean by "things are way more different"?
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by gwerbret 6y ago
> Who are you accusing of a "dangerous misunderstanding" here – her, or me? I wasn't accusing anyone specifically, merely commenting on the idea you shared. However, since you asked, I would say that the misunderstanding i
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by gwerbret 6y ago
> She simply argues that the symptoms are caused by numerous unknown diverse causes in the brain, and the concept of a single disorder (ASD), or even a spectrum of related disorders (ASDs, the DSM-IV PDDs, and more recent ASD sub-typing

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