gmorainbows

3 ms·

1. 1.▲
   by gmorainbows 6y ago

   I'm honestly not familiar with "deep mutational scanning." Can you share a link? I'm first author on papers related to the structural biology of coevolution and I competed in CASP about a decade ago, but I haven't k
2. 2.▲
   by gmorainbows 6y ago

   It doesn't matter so much how they perform the feature extraction, so much as what their inputs to the feature extraction are. This model requires a collection of wild-type proteins in an accurate MSA. Producing an accurate MSA is hard
3. 3.▲
   by gmorainbows 6y ago

   The method relies on multiple-sequence-alignment (MSA) of homologous proteins. This cannot fold arbitrary proteins, only biologically relevant ones that have high quality MSAs available. It's also worth pointing out that the gold-stand