flobosg

15 ms·

1. 211.▲
   by flobosg 2y ago

   I still remember his “The Art of Code” talk, highly recommended: https://www.youtube.com/watch?v=6avJHaC3C2U
2. 212.▲
   by flobosg 2y ago

   Along the same topic: Obituary for a quiet life (2023) – https://news.ycombinator.com/item?id=40028643
3. 213.▲
   by flobosg 2y ago

   Feed aggregators: https://en.wikipedia.org/wiki/Planet_(software)
4. 214.▲
   by flobosg 2y ago

   http://archive.today/rNjf1
5. 215.▲
   by flobosg 2y ago

   (2023)
6. 216.▲
   by flobosg 2y ago

   Here’s a text editor written with LÖVE: https://akkartik.name/lines.html
7. 217.▲
   by flobosg 2y ago

   I like the Jetstream, but for some reason they dry out or the ball seems to get clogged (with skin oils or paper fibers, maybe?) after some time using them.
8. 218.▲
   by flobosg 2y ago

   Are the colors swapped? From the article: > The colors are a mix of oranges (for temperatures) and blues (for precipitation).
9. 219.▲
   by flobosg 2y ago

   (2021)
10. 220.▲
    by flobosg 2y ago

    (2019)
11. 221.▲
    by flobosg 2y ago

    > Television? The word is half Greek and half Latin. No good will come of this device. ―C. P. Scott
12. 222.▲
    by flobosg 2y ago

    (2014)
13. 223.▲
    by flobosg 2y ago

    Unintended rubrication, perhaps? – https://gwern.net/red
14. 224.▲
    by flobosg 2y ago

    It seems that Google Translate assumes Chinese as the source language, instead of Japanese.
15. 225.▲
    by flobosg 2y ago

    > this is what I mean by "a shitty answer fast" - structure prediction isn't a canonical answer A proper protein structural model is an all-atom representation of the macromolecule at its global minimum energy conformation
16. 226.▲
    by flobosg 2y ago

    > Rosetta used sequence homology Rosetta used remote sequence homology to generate the MSAs and find template fragments, which at the time was innovative. A similar strategy is employed for AlphaFold’s MSAs containing the evolutionary
17. 227.▲
    by flobosg 2y ago

    AlphaFold and Folding@home attempt to solve related, but essentially different, problems. As I already mentioned here, protein structure prediction is not fully equivalent to protein folding.
18. 228.▲
    by flobosg 2y ago

    Same with Rosetta, and even Foldit[1]! – https://www.nature.com/articles/nsmb.2119 [1]: https://en.wikipedia.org/wiki/Foldit
19. 229.▲
    by flobosg 2y ago

    > and used just tiny fragments from the PDB 3-mers and 9-mers, if I recall correctly. The fragment-based approach helped immensely with cutting down the conformational search space. The secondary structure of those fragments was enough t
20. 230.▲
    by flobosg 2y ago

    > Let me get the most important question out of the way: is AlphaFold’s advance really significant, or is it more of the same? I would characterize their advance as roughly two CASPs in one ― https://moalquraishi.wordpress.com&
21. 231.▲
    by flobosg 2y ago

    > A breakthrough in folding would have produced folding rules that are universal. Protein folding ≠ protein structure prediction > I think those who invented pairwise and multiple alignment dynamic programming algorithms deserved some
22. 232.▲
    by flobosg 2y ago

    AlphaFold2 has correctly predicted novel folds: https://www.nature.com/articles/s42003-022-03357-1
23. 233.▲
    by flobosg 2y ago

    (2021)
24. 234.▲
    by flobosg 2y ago

    My comment from a few months ago ( https://news.ycombinator.com/item?id=40857263 ): > In the 2000s the Chilean state railway company was involved in a huge corruption scandal as well as bad administrative practices. It’s b
25. 235.▲
    by flobosg 2y ago

    For reference: List of artists and entertainers with advanced degrees – https://en.wikipedia.org/wiki/List_of_artists_and_entertaine...
26. 236.▲
    by flobosg 2y ago

    The repository seems to have been moved to https://codeberg.org/nibbula/yew/src/branch/master/lish
27. 237.▲
    by flobosg 2y ago

    The topic was hyped a few years ago, for example on https://www.quantamagazine.org/a-newfound-source-of-cellular...
28. 238.▲
    by flobosg 2y ago

    > I won't have a career in academia.
29. 239.▲
    by flobosg 2y ago

    Mate cocido as well: https://en.wikipedia.org/wiki/Mate_cocido
30. 240.▲
    by flobosg 2y ago

    Don’t overthink it: add some yerba mate into a container, put the straw ( bombilla ), use a thermos to pour some hot water[1], sip it, pour again. [1]: Or cold if you fancy – https://en.wikipedia.org/wiki/Terer%C3%A9