flobosg

34 ms·

541.
by flobosg 4y ago
(2008)
542.
Coffee vs. Tea Smackdown(washingtonpost.com)
1 points by flobosg 4y ago|0 comments
543.
by flobosg 4y ago
In a similar vein: https://www.jeffbridges.com/
544.
by flobosg 4y ago
The CSS stylesheet is available at https://github.com/rougier/emacs-gtd/blob/master/GTD.css
545.
by flobosg 4y ago
FWIW, I understood it as literally breaking (interrupting? halting?) a machine by mistake.
546.
Psychedelic microdosing hits a rough patch in clinical trials(nature.com)
3 points by flobosg 4y ago|0 comments
547.
In Chile's desert lie vast reserves of lithium – key for electric car batteries(npr.org)
12 points by flobosg 4y ago|0 comments
548.
The controversial embryo tests that promise a better baby(nature.com)
2 points by flobosg 4y ago|0 comments
549.
by flobosg 4y ago
This is already known. Structural models are usually not well suited for protein-ligand docking, where proper pocket modelling and accurate side chain positioning are key for the determination of true positive hits.
550.
by flobosg 4y ago
> that doesn't 100% accurately represent reality It could be argued that this is the case of every scientific tool ever used.
551.
by flobosg 4y ago
Related: “The perfect human is Puerto Rican” – https://liorpachter.wordpress.com/2014/12/02/the-perfect-hum...
552.
Quantum Computing Comes to the Rescue?(science.org)
1 points by flobosg 4y ago|0 comments
553.
by flobosg 4y ago
Cofactor- or chromophore-binding proteins are usually colored, which is quite useful during expression and purification. The quintessential example is GFP or GFP-tagged proteins.
554.
by flobosg 4y ago
One goal of protein design is to create bespoke enzymes that catalyze reactions of interest, such as the degradation of target compounds. Keep in mind that the vast majority of de novo designed proteins to date lack a defined function and
555.
by flobosg 4y ago
What other sites redirect HN referers? I only know of jwz’s one. (Don’t try it at work!)
556.
by flobosg 4y ago
There has been some applications of machine learning in the field of molecular dynamics (and therefore protein folding simulations). Here’s a review from 2020: http://public-files.prbb.org/publicacions/ca66c5f0-0f76-013
557.
by flobosg 4y ago
The same could be said of almost all research, but I see your point. Time will tell, I guess.
558.
by flobosg 4y ago
SDS-PAGE is the normal way, at least for an initial test expression. For a Western blot or ELISA you need antibodies specific to your protein, which you probably don’t have. An easier way to identify, for example, would be to cut the SDS-PA
559.
by flobosg 4y ago
Those 150 designs were probably early proofs of concept hallucinated using e.g. RoseTTAFold; Baker has been thinking about protein hallucination for a while already.
560.
by flobosg 4y ago
When you express recombinant proteins in bacteria, you grow them and then let them produce your protein of interest. Then you destroy the bacteria and separate the soluble parts (where you hope your protein stays) from the insoluble ones (p
561.
by flobosg 4y ago
DeepMind has a website highlighting some of the applications of AlphaFold ( https://unfolded.deepmind.com ), and apparently it has improved at least some lines of research.
562.
by flobosg 4y ago
Protein design protocols usually favor globular, soluble proteins, where the sort of interactions generating amyloids and prions are absent.
563.
by flobosg 4y ago
Snark aside, this is not AlphaFold per se , but sort of a reverse AlphaFold, the same way protein design can be defined as the inverse protein folding problem.
564.
by flobosg 4y ago
Something similar happens in Germany: https://en.wikipedia.org/wiki/Kevinismus
565.
by flobosg 4y ago
Link to the article: https://journals.plos.org/plospathogens/article?id=10.1371/j...
566.
by flobosg 4y ago
Discussion from a few days ago: https://news.ycombinator.com/item?id=32755009
567.
by flobosg 4y ago
The samples were stored at -80°C, where any chemical degradation process would be slowed down immensely if not come to a virtual halt.
568.
by flobosg 4y ago
Another data point: The Reitaisai[1], a convention focused solely on Touhou Project, where hundreds if not thousands of circles (groups) sell fan-made content, including music. [1]: https://en.wikipedia.org/wiki/Touhou_
569.
by flobosg 4y ago
If you want to have an idea of the molecular mechanisms involved, last year the structures of an insect odorant receptor in complex with two different odorants was published: https://www.nature.com/articles/s41586-021-0
570.
Konrad Hinsen – Nix/Guix and Reproducible Science(youtube.com)
3 points by flobosg 4y ago|0 comments

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