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f6v
searching PlanetScale…
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106 ms
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781.
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f6v
5y ago
GTA 5 came before everyone felt the need to be offended though. It’s almost like we live in a satire reality already.
782.
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f6v
5y ago
GTA online is the reason there was no GTA 6 yet. It’s just making too much money to care.
783.
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f6v
5y ago
I was thinking that GTA in Mexico or Colombia would be lit. But they keep it to the US.
784.
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f6v
5y ago
> for both - immigration Yes, let some county train those guys and we’ll just get them for free.
785.
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f6v
5y ago
Anecdotally, haven’t seen a young tradesmen in Germany while I lived there.
786.
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f6v
5y ago
Where can I read that message? I don’t follow many news channels. But I visited CDC website and their primary message is that vaccines protect from getting seriously ill.
787.
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f6v
5y ago
Because some times you have to make a call. Some studies are now revealing that booster shots might be less effective in those who recovered (watched a guy present his unpublished data the other day). But it’s not that obvious.
788.
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f6v
5y ago
Workers expect that incredible progress in automation (all the computers) would allow them to work less than before the automation has been made possible. And instead the Dutch will take the bridge apart to let Bezos’ mega yacht out into
789.
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f6v
5y ago
One reason would be that CD4 and CD8 populations undergo major changes with age. There’s a shift towards exhausted phenotype. Immune system produces fewer and fewer naive T cells in the bone marrow, thymus is less efficient in adulthood as
790.
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f6v
5y ago
Not familiar with tumor immunology but I’d imagine it could be challenging to get CAR-Ts to infiltrate the tumor on demand.
791.
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f6v
5y ago
Europe has rail. Does anyone know if they use fewer trucks than in the US?
792.
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f6v
5y ago
> Most people are not nerds like us and prefer to interact with people in person. People are also glued to phones. Children are making TikTok videos. My point is that people do interact online. The issue with VR is fidelity. It just does
793.
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f6v
5y ago
If Facebook and Instagram proved something it’s that you either need dancing half-naked teenagers or conspiracy theories on your network to keep the engagement.
794.
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f6v
5y ago
Telegram is very much about content sharing. News, hobby groups, paid adult content, crypto scams, memes - it has it all. Although primarily in Russian.
795.
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f6v
5y ago
At the moment I’m working in genomics analyzing the next-generation sequencing data. My primary academic interest is in ageing. I’d love to turn that into a business interest as well. But something in the area of genomic disease markers wil
796.
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f6v
5y ago
I was working on enterprise Google Glass apps in 2014. The problem was lack of applications. You could do very few things with it beyond showing some text and pictures.
797.
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f6v
5y ago
People are discussing whether AR device could be worn in public. But I’m wondering: should it? I mean, I’m the last guy to question novel technology. I was desperate to get the first smartphones. But why would you want an always-on screen i
798.
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f6v
5y ago
Do we forget that AirPods solved a real pain? No more tangled wires, and they were the first in-ears I actually found comfortable.
799.
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f6v
5y ago
A long short but I’m a PhD student in medicine with focus on bioinformatics. I have extensive prior experience in software development. Hit me up at i.am.filippov at gmail if you have something deep tech healthcare-related in mind.
800.
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f6v
5y ago
It seems you’re debunking the claims I’ve never made. My point was that it doesn’t matter that mRNA vaccine can be developed extremely fast compared to others, like adenovirus-based. The logistics and production will even it out.
801.
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f6v
5y ago
Don’t get me wrong, I got my 3 Covid shots. But that’s within 6 months. No other vaccine is that frequent.
802.
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f6v
5y ago
I think you underestimate the effort needed to create an immunogenic vaccine candidate that doesn’t have unwanted side effects. That’s one of the reasons CureVac failed: https://www.nature.com/articles/d41586-021-01661-
803.
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f6v
5y ago
I somewhat agree, but condoms aren’t just for HIV and save from other potentially lethal diseases. So the benefit is just enormous, yet folks still don’t use them. At the same time, look the vaccination rates in the Eastern Europe. I suspec
804.
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f6v
5y ago
If we had robust enough theory of vaccine testing it wouldn’t matter what kind of vaccine you develop, right?
805.
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f6v
5y ago
What I’m trying to say is that mRNA vaccines might not be faster to deliver to market because you still need to go though testing and approval.
806.
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f6v
5y ago
> The traditional vaccines don't work any better. Didn’t say they were. Rather that mRNA don’t seem to be approved faster for the new variants. > This is evidence MRNA is better than traditional vaccines. Haven’t been following t
807.
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f6v
5y ago
Yes, but what I meant was those would be already approved.
808.
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f6v
5y ago
I guess the same as in diseases like tuberculosis. I’ve just read an article where they studied immune responses in recent TB infections. The authors recruited subjects from South Africa. I think it’s not that hard to get them to join the t
809.
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f6v
5y ago
It’s hot tech, maybe driven by the desire to pump share prices.
810.
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f6v
5y ago
Regarding your second point, isn’t HIV a preventable disease? In the areas where the prevalence is in double digits, people don’t seem to be using condoms or taking other precautions. Why would they be taking vaccine every year?
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