evandijk70

11 ms·

91.
by evandijk70 4y ago
> Risk budget How does a smaller risk budget reduce the chance of type I error? Also, a lot of care would have to be taken that all smaller studies are pre-registered as well as their outcomes. > Unblinding In practice, things happen
92.
by evandijk70 4y ago
You are comparing the wrong numbers, 5 year-OS vs objective response. Objective response is 46% in the study you cited (Table 2). 5 year-OS is nearly always lower. The patients in the new study were only followed for a median of 6.8 months,
93.
by evandijk70 4y ago
This sounds good, but there are a lot of practical problems: 1. How do you account for multiple testing? To ensure that the treatment actually works, you need to show a statistically significant difference between control group and experime
94.
by evandijk70 4y ago
Do you really believe that there are people that can't make their life work without making frequent 100+ mile long trips?
95.
by evandijk70 4y ago
I'm from Europe, and have never seen anyone use a gas-powered leaf-blower, pressure washer, or weed wacker in their garden. Do you really need them?
96.
by evandijk70 4y ago
What about a researcher that measures the kinetics of AB-aggregation in vivo, performs X-Ray crystallography to determine the structure of this (or another amyloid), or performs simulations to determine free binding energies of various anti
97.
by evandijk70 4y ago
I agree that the power of punishment as a deterrent is unclear, but your car example does not hold up, since there are a lot more bikes stolen than cars. Official reported thefts from the Netherlands [1](Note that the number of bike thefts
98.
by evandijk70 4y ago
Basic capitalism does have something to do with Netflix' problem. However, nowhere in capitalism does it say that you need endless growth. Netflix' valuation was dependent on growth (as signalled by its' PE ratio). Basic cap
99.
by evandijk70 4y ago
Do you mean cable television? To me, Netflix is the same to cable television as Spotify is to radio, so I'm not sure I see a big benefit of Spotify there.
100.
by evandijk70 4y ago
Fiber was installed here, and they provide three tiers - 50Mb/s, 100 Mb/s and 1000 Mb/s, for 45, 50, and 55 euro each. We took the 100Mb/s. I have no idea what I would use 1 Gb/s for, using it as definition for broa
101.
by evandijk70 4y ago
There is indeed about a 30% reduction in power usage when comparing trams to electric buses. https://bathtrams.uk/the-most-energy-efficient-mode-of-publi... Still, I feel that trams will be dying soon. The improved efficien
102.
by evandijk70 4y ago
You still need tracks and power lines. If the only benefit of streetcars over buses is right-of-way, why not just give buses right of way. After some deliberation, my muncipality recently decided against a streetcar-system and for a bus-bas
103.
by evandijk70 4y ago
To me it seemed that people would bike/walk instead. I still let the trolley continue though.
104.
by evandijk70 4y ago
Interesting, that is also not the case in the Netherlands. I've never been able to specify the limit, which was recently increased nationwide from 125 euro to 200 euro.
105.
by evandijk70 4y ago
I only get gas from an unmanned gas station, as it is close to my house and the cheapest option. For someone living paycheck to paycheck, price is especially important, and this approach does not work.
106.
by evandijk70 4y ago
This gives me the idea of a race for autonomous, RC-sized cars. A lot cheaper and safer, but probably just as fun.
107.
by evandijk70 4y ago
Please provide a source that 'most people don't want a smart TV'. That is not my experience at all.
108.
by evandijk70 4y ago
Another question: how common are GPCR-antibodies in non-covid patients?
109.
by evandijk70 4y ago
Accepting is different than celebrating. I disagree that it's part of the zeitgeist. The zeitgeist is that you and your life have to be perfect, because that is the image you get from everyone on social media.
110.
by evandijk70 4y ago
What if your car suddenly breaks down and you have to replace it? Is the extra income of investing, let's say, 3 months of expenses really worth it? Let's say you get 3% in an instant savings account, and 3.5% in a three months&#x
111.
by evandijk70 4y ago
As someone who probably falls partly under your definition of 'wasteful': I don't like planning, and I forget things. So I sometimes leave the light on when I leave the house, forget something when I have to do groceries at t
112.
by evandijk70 4y ago
Exactly - in the Netherlands we have the reverse problem - if a generic drug exists, some insurance companies will only reimburse that drug. In some cases that leads to problems. One example was a generic drug where some patients were aller
113.
by evandijk70 4y ago
You might be able to make an informed decision. Most people (and most doctors, for that matter), are not qualified to accurately judge the many uncertainties, biases and trade-offs present in drugs only tested in early stage clinical trials
114.
by evandijk70 4y ago
In the Netherlands, 30k is the starting salary for a PhD student. 30k for a tenure track position sounds insane to me.
115.
by evandijk70 4y ago
If 'bugs are evolving to eat plastic' does that not mean that the bacteria that can metabolize plastic are outcompeting wildtype strains, not the other way around?
116.
by evandijk70 4y ago
Could you provide a source for these statements? In another comment I gave a link to a publication that summarized the literature comparing heel striking to forefoot striking, which showed no consensus on which is better.
117.
by evandijk70 4y ago
This is indeed a popular theory in the running community, and many runners have made an effort to transition to landing on their forefoot rather than their heel. However, there does not appear to be a scientific consensus whether runners wi
118.
The email Zuckerberg sent to cut out his former coworker (2012)(businessinsider.com)
7 points by evandijk70 4y ago|0 comments
119.
by evandijk70 4y ago
An average US household. In Europe it is more like 10 kWh. Why there is such a large difference I do not know.
120.
by evandijk70 4y ago
Note that the Tesla Powerwall is already quite heavy: 97 kg (250 lb). A sodium based battery will double that, which would make the logistics of transport and installation harder. So weight is not totally irrelevant for home storage.

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