3 ms·

Another question: how common are GPCR-antibodies in non-covid patients?

• cjbgkagh 4y ago
  I think just about everyone has some level of GPCR-antibodies present just that people with long-covid have much greater amounts of them.
• robonerd 4y ago
  Very common, no doubt. Targeting GPCRs is a very wide net, GPCRs are a huge superfamily of proteins. > GPCRs are an important drug target and approximately 34%[6] of all Food and Drug Administration (FDA) approved drugs target 108 members of this family. The global sales volume for these drugs is estimated to be 180 billion US dollars as of 2018.[6] It is estimated that GPCRs are targets for about 50% of drugs currently on the market, mainly due to their involvement in signaling pathways related to many diseases i.e. mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. The long ago discovered association between GPCRs and many endogenous and exogenous substances, resulting in e.g. analgesia, is another dynamically developing field of the pharmaceutical research.[2]
  • yunohn 4y ago
    I’m not a medical expert, but antibodies and auto-antibodies are not the same thing.
    • robonerd 4y ago
      An auto-antibody is any antibody targeting your own proteins. My point is GPCR is not a protein, but a huge family of proteins that are broadly relevant to a huge range of conditions.