drew1492

3 ms·

1.
by drew1492 5y ago
Benzodiazepines (Xanax, Valium, etc.) are basically that - GABAergics with very high LD50. They're positive allosteric modulators, rather than direct agonists, but the pharmacological action is similar. But benzos wouldn't be a go
2.
by drew1492 5y ago
This is not true, or partially true at best. As far as I'm aware, current consensus is that psychedelics are not a causative agent in psychosis or schizophrenia in the absence of predisposing risk factors. 0.5-1% of the population will
3.
by drew1492 5y ago
Kava's nice but getting the desired effects can be a bit hit-or-miss. It's milder and more of a clearheaded serene/sedate effect, tastes like dirt-water, and can be a bit expensive, about on par with craft beers. But it'
4.
by drew1492 5y ago
GHB, for one, is said to be all the best parts of alcohol with less of the downsides. It's still addictive and super illegal though, has the stigma of being a "date-rape drug", is maybe more neurotoxic than ethanol (excitot
5.
by drew1492 8y ago
That comment is using net worth, not yearly income, as the yardstick.
6.
by drew1492 8y ago
The word "toxic" is overloaded and there are at least two main types of "toxicity" - acute and chronic. Caffeine is indeed more acutely toxic than cannabis in the sense that one could die from taking waay too much caffei
7.
by drew1492 9y ago
Spending down your principal may not be a smart idea though, especially if one is in good health. It runs the risk of them outliving their savings. Spending 4% or less of your assets annually is sustainable indefinitely, statistically speak