dekhn

34 ms·

781.
by dekhn 1y ago
Yes, that's exactly right. this is NewsWire for science.
782.
by dekhn 1y ago
There is a big long-running argument about what "functional" means in "non-coding" parts of the genome. The deeper I pushed into learning about the debate the less confident I became of my own understanding of genomics
783.
by dekhn 1y ago
It's not really just base pairs forcing groove structure. The repulsion of the highly charged phosphates, the specific chemical nature of the dihedral bonds making up the backbone and sugar/base bond, the propensity of the sugar
784.
by dekhn 1y ago
STATE is not a simulation. It's a trained graphical model that does property prediction as a result of a perturbation. There is no physical model of a cell. Personally, I think arc's approach is more likely to produce usable sci
785.
by dekhn 1y ago
No; what they drew doesn't look like real DNA or (duplex double stranded) RNA. Both have differently sized/spaced grooves (see https://www.researchgate.net/profile/Matthew-Dunn-11/publica... ). At least
786.
by dekhn 1y ago
That's correct. I can't even really take credit for any of the really nice work, as much as I wish I could!
787.
by dekhn 1y ago
When I went to work at Google in 2008 I immediately advocated for spending significant resources on the biological sciences (this was well before DM started working on biology). I reasoned that Google had the data mangling and ML capabilit
788.
by dekhn 1y ago
I'm not opposed to transparency or detailed diffs, but are individuals really able to make informed decisions about this? I work in the pharma industry and know plenty about drugs but I feel like I'd want an expert to make decisi
789.
by dekhn 1y ago
Nobody denied that there was mercury (in thimerosal) in vaccines. That was not being hidden. The FDA started to phase its use out in 1999. You mention that phenol is used in mouthwash, so you follow up with "inject that mouthwash int
790.
by dekhn 1y ago
Yes, you probably interacted with my coworker Jeff (first on this list: https://research.google/blog/millions-of-core-hours-awarded-... )
791.
by dekhn 1y ago
It's very unlikely we're going to inject prions into poultry. Clicking on the article, you can see the author has a clearly stated bias: "Sean witnessed the corruption within the system and developed a burning desire to expo
792.
by dekhn 1y ago
Sure, that also works, although it often leads to problems around cost and scalability and environment customization.
793.
by dekhn 1y ago
I've setup and built my own machines and clusters, as well as setting up grids, and industrial scale infrastructure. I've seen many closet clusters, and clusters administrated by grad students. Since then, I've gone nearly
794.
by dekhn 1y ago
We also simulated the LSST- in this case, using Exacycle at google (an idle cycle harvester). We took a star catalog and passed it through a highly accurate ray tracer that simulated the light falling on the sensors (through space, atmosph
795.
by dekhn 1y ago
I've worked on quite a few large-scale scientific collaborations like this (and also worked on/talked to the lead scientists of LSST) and typically, the end groups that do science aren't the ones handling the massive infrastr
796.
by dekhn 1y ago
Certainly a subset of PhDs who work at bigtech fail to have any impact. I've seen a few brilliant but inflexible people hit up against the immovable parts of a corporation. I've also seen brilliant PhDs who refuse to study for a
797.
by dekhn 1y ago
He's on garden leave, so he's still employed, and has badge access to the office (but no formal responsibilities) for 6 months after the notification (plus another 3 months pay).
798.
by dekhn 1y ago
That's a great question. To the extent that increasing the budget caused more smart people to get PhDs and more of them were able to contribute to the scientific effort (as well as help bigtech develop ML and contribute back to scienc
799.
by dekhn 1y ago
Again, nothing special. The small outfits aren't going to be doing the critical processing.
800.
by dekhn 1y ago
This happened when I was in grad school back in the late 90s. Clinton increased the budget of the NIH significantly (thanks Bill) which led to a huge increase in training grants allowing PhD programs to expand. However, faculty positions
801.
by dekhn 1y ago
I've followed this project for over a decade and the amount of data they are moving around is fairly routine, given their budget size and access to computing and networking resources. The total storage (~40-50PB) is pretty large, but
802.
by dekhn 1y ago
The US already has a very sophisticated system for this. https://en.wikipedia.org/wiki/United_States_Space_Surveillan...
803.
by dekhn 1y ago
I really like the Rubin because I think a lot of people focus too much on "deep" seeing (IE, looking at individual or several objects with very high magnification only once). The Rubin does much more "wide" seeing and t
804.
by dekhn 1y ago
The odyssey because it's the basis function for most of western thought (wily male human outsmarts gods, witches, and suitors on a long journey home). The best implementation of the monomyth, imho. Moby Dick because it's not just
805.
by dekhn 1y ago
The Odyssey, Moby Dick, Fire Upon the Deep.
806.
by dekhn 1y ago
That's a very clever joke. The article is basically saying that the authors of the Stochastic Parrot article (and their adherents) assume that humans have some sort of special magic that cannot be simulated using machine learning, and
807.
by dekhn 1y ago
It took me decades to learn these lessons on my own. many, many shiney rock lost to agile shaman!
808.
by dekhn 1y ago
The point of wayland was that the developers of X11 with the greatest experience concluded they no longer wanted to work on Xorg, and designed a new protocol taking into account their experience as well as knowledge of how desktops have cha
809.
by dekhn 1y ago
I'll never forget bromine, fuming brown off whatever high school reaction we were doing that day.
810.
by dekhn 1y ago
the evidence may be strong, but the effect size compared to the relative dosing shows they are probably misclassified.

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