dekhn

5 ms·

31.
by dekhn 1mo ago
An opportunity to correct myself? Respectfully, I decline. If you have trouble parsing my sentence, it's not meant for you.
32.
by dekhn 1mo ago
Based on: my experience working on AI for 32 years, including a decade at Google including working on large-scale model training systems that used user data and complied with various user policies around data retention, along with a few dec
33.
by dekhn 1mo ago
It seems like we can skip much of the expensive modelling and use evolutionary conservation data to shortcut building a full latent space that captures all salient interactions. It's unclear to me whether we truly need to model the en
34.
by dekhn 1mo ago
I work in pharma and I've advocated for directly training models that predict drug trial outcomes. I don't think we have the necessary support (data + algorithms) to produce accurate models in this space. I suspect that predicti
35.
by dekhn 1mo ago
Only if you interpret statements as being binary logic. "seem to be" carries semantic meaning here: I'm stating my interpretation of the situation based on data we have available (which is limited) and my prior. Put another w
36.
by dekhn 1mo ago
I don't think you're taking this thread seriously enough to respond in detail. A university can be tiny, or it can have thousands of researchers. Some of them might want to work on small models, and others on huge frontier models
37.
by dekhn 1mo ago
Sure, they have clusters. We often call them "closet clusters". Nothing has changed. Some institutions have larger systems (some extremely large) but none of them have demonstrated running warehouse-scale systems. I'm tal
38.
by dekhn 1mo ago
From the perspective of those who don't pass through the singularity to the other side, it is an endpoint. You would have no context or ability to understand a singularity transition. Really, the term is just a placeholder for &quo
39.
by dekhn 1mo ago
We don't have enough accurate knowledge to say that, and it doesn't seem to be the case at all.
40.
by dekhn 1mo ago
We don't have any proof of that at all. Please stop rushing to judge without data.
41.
by dekhn 1mo ago
Oh, I'm pretending that's not canon because it doesn't make any sense and it undermines the original scene.
42.
by dekhn 1mo ago
There's a scene in the movie "War of the Worlds" by Spielberg where the protagonist's son walks into a war zone because he is entranced by the battle ( https://www.youtube.com/watch?v=X7rfWPbEufo ). He is
43.
by dekhn 1mo ago
Um.... good! Mission accomplished.
44.
by dekhn 1mo ago
I would be excited if somebody could use this to show an unexpected or interesting behavior in the real world. Tao mentioned "finding a configuration of water molecules that would collapse and shoot off to infinity", which would q
45.
by dekhn 1mo ago
LOL, have you worked for a big university? They are massively unsuited for building and running datacenters (especially warehouse-scale ones). Further, building an AI datacenter in California is daft.
46.
by dekhn 1mo ago
Eye color is not discrete Mendelian. That's only correct to the first order. Also Mendelian has little to do with promotor sequences or differential transcription in deviations.
47.
by dekhn 1mo ago
This is not a coherent argument.
48.
by dekhn 1mo ago
Is that necessarily wrong, so long as the original innovators get a citation credit?
49.
by dekhn 1mo ago
If your question is "what is the most rational process to follow to reduce the impact of the current administration on US aid funding around the world", then I think getting as many people to vote for democrats is probably the bes
50.
by dekhn 1mo ago
Speaking as somebody who has worked within Google Research before: the researchers are under tremendous pressure to publish SOTA and sometimes they juice their results a bit to look competitive when they can't match. This is not uncom
51.
by dekhn 1mo ago
That's an interesting statement: "The gist was, can existing variation provide enough context to infer impact of variation? The answer seemed to be no." Is this saying that if we were to sequence every human being on the plan
52.
by dekhn 1mo ago
So it sounds like you're coming to this with very little knowledge about biology. I encourage reading up on modern challenges in pathogenic prediction, especially with regards to SNPs: on their own, with the exception of a few disease
53.
by dekhn 1mo ago
This has nothing to do with AlphaFold at all- not sure if you were implying that. (the scientific contriution is welcome, but it's not particularly significant)
54.
by dekhn 1mo ago
Thanks, this is more thoughtful than most of the replies I've seen. I don't think anybody proposed or considered running a randomized trial. I feel like the evidence standard has to be extremely high if you're claiming that t
55.
by dekhn 1mo ago
Not really, no.
56.
by dekhn 1mo ago
Individual SNP predictions are not useful for drug discovery. Pharma might license this, but mainly out of fear of missing out.
57.
by dekhn 1mo ago
Sure, what Elon and his DOGE buddies did was a travesty. But I believe if we're going to fight this, we can't just rest on arbitrary made-up numbers of foreign deaths as a reason to retain a funding vehicle.
58.
by dekhn 1mo ago
false claim of causality (post hoc, ergo propter hoc).
59.
by dekhn 1mo ago
Nope. And I hate that entire comic for poisoninh the very idea that asking for the evidence is wrong. I'm operating in good faith asking people to show data. There is no reliable data supporting the claim that millions of people died
60.
by dekhn 1mo ago
The Harvard articfle is just PR for a documentary that focuses on an individual (IE, an anecdote intended to be emotionally manipulative). As for the article, this is modelling, not data (both the retrospective and the predictive). There i

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