david_l_lin

8 ms·

31.
by david_l_lin 4y ago
The rise of zoonotic infections should not be surprising at all given the rate of deforestation and general disregard for nature.
32.
by david_l_lin 4y ago
I find that many of the PhD students who struggle are not prepared for the mostly self-driven nature of the pursuit, and have not had enough work experience to know how to choose a supervisor. The statistics support this: a majority of the
33.
by david_l_lin 4y ago
Hi! That's a great question that we've heard more than once. We're compiling the data, and so far we simply don't have enough data around water flossing vs string to draw any conclusions. In general, it definitely appear
34.
by david_l_lin 4y ago
This is an excellent anecdote for exactly why we are building Bristle. We're finding more and more that oral health is not a one-size fits all. I'm glad you've been able to find something that works for you. If you look close
35.
by david_l_lin 4y ago
cofounder at Bristle here. Unfortunately there is a lack of data around the efficacy of behavioral, lifestyle, and product interventions on oral health despite decades of dentists telling their patients to "brush and floss more".
36.
The effect of flossing on the oral microbiome, gum disease, and bad breath(bristlehealth.com)
35 points by david_l_lin 4y ago|19 comments
37.
by david_l_lin 4y ago
I’m glad you brought up the history of halitosis and marketing. In fact, the oft recommended twice-per-year visit to the dentist began as a pepsodent ad! It turns out that in low risk individuals, the frequency of dental cleaning and checku
38.
by david_l_lin 4y ago
Regular oral hygiene is a decent predictor of oral health. However this does not explain why the incidence of caries and irreversible gum disease are so high. Almost half of all Americans have some form of gum disease, which we can predict
39.
by david_l_lin 4y ago
Depending on your oral microbiome, there are more specific mouthwashes that primarily target anaerobic species that are implicated in diseases like gum disease and halitosis. Fluoride is highly effective at reducing caries incidence, but so
40.
by david_l_lin 4y ago
This is because of negative impacts that broad antimicrobials have on your oral microbiome. These mouthwashes essentially burn away your microbiome and allow for new species to repopulate the niche. Many times this means that anaerobic spec
41.
by david_l_lin 4y ago
Not directly related, but Listerine and other broad antimicrobial mouthwashes have been shown to have a negative impact on the oral microbiome similar to how antibiotics cause dysbiosis in the gut. At Bristle Health, we advocate for product
42.
by david_l_lin 4y ago
Might be related, but mouthwash use is correlated with a drop in systemic nitric oxide levels due to the negative impact on the oral microbiome. You can find a review here: https://pubmed.ncbi.nlm.nih.gov/35081826/ At
43.
Bristle (YC W21) is hiring engineers to prevent gum disease and bad breath(bristle.notion.site)
1 points by david_l_lin 4y ago
44.
by david_l_lin 5y ago
The associations between gut microbes and disease may be valid, but simply not actionable. The gut has incredible size, and is thousands of niches rather than a bag of marbles. The oral microbiome, however, is an entirely different story. D
45.
Bristle (YC W21) is hiring a front-end engineer to improve oral health care(bristle.notion.site)
1 points by david_l_lin 5y ago
46.
by david_l_lin 5y ago
Bristle (YC W21) | Software Engineer | San Francisco Bay Area, San Diego, US | REMOTE | Full Time | https://www.bristlehealth.com/ Bristle is a consumer wellness biotechnology company that leverages genomics and the oral m
47.
by david_l_lin 5y ago
Bristle (YC W21) | Multiple Positions | San Francisco Bay Area, San Diego, US | Remote possible | Full Time | https://www.bristlehealth.com/ Bristle is a consumer wellness biotechnology company that leverages genomics and t
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Bristle (YC W21) is hiring engineers to improve oral health care(bristle.notion.site)
1 points by david_l_lin 5y ago
49.
by david_l_lin 5y ago
Caveat: I did not read the paper but can weigh in on this: 1. The eye has immune privilege, similar to that of the brain, meaning it can tolerate antigens that would normally trigger an immune response elsewhere, like your arm. 2. Fragments
50.
by david_l_lin 6y ago
Halitosis is absolutely a wellness indication that we eventually plan to report on as we gain more insight to the pathways involved. A number of studies have suggested that sulfate reducing bacteria may be a culprit for bad breath, and we e
51.
by david_l_lin 6y ago
We do not sell personal microbiome, genetic, or survey-related data and don't have plans to do so. We will make every effort to keep your personal data yours. We de-identify all your data so that it can only be analyzed as an aggregate
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by david_l_lin 6y ago
There have been some intriguing studies associating the oral microbiome with systemic diseases such as cardiovascular indications, diabetes, oral cancers, and neurological diseases such as Parkinson's and Alzheimer's. Some studies
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by david_l_lin 6y ago
One major feature of gram-negative bacteria is their production of LPS, which is inherently inflammatory and can contribute to disease. That said, many gram-positive bacteria can also be pathogenic. The relationship between bacterial pathog
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by david_l_lin 6y ago
A majority of the products marketed today non-specifically ablate the microbiome. While they are effective at reducing the microbial titer as a whole, they are ineffective at specifically targeting pathogenic microbes associated with diseas
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by david_l_lin 6y ago
Definitely! There's still a lot of unknowns in the microbiome space, and it's something we hope to look into as we gather more data. Some studies have suggested that adolescent oral microbiome profiles can serve as indicators of f
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by david_l_lin 6y ago
Well said! Incumbents in the space have a lot to gain from the status quo of "drill, fill, and bill". This has limited the adoption of new diagnostic technology and advances in preventive health. We hope to eventually replace obse
57.
by david_l_lin 6y ago
Forgoing the details, from the user perspective, the product is almost entirely direct to consumer, and the Bristle platform provides users the opportunity to both request a test and further consult with a dentist. Prescriptions and interve
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by david_l_lin 6y ago
Regarding the oral focus: Our core technology is based around the oral microbiome for a number of key reasons. 1. decades of research have shown causal relationships between the oral microbiome and preventable gum disease. 2. the oral micr
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by david_l_lin 6y ago
Great question! We recommend a cadence similar to that of a dental checkup (at least every 6 months) depending on your oral health status. We will eventually provide insight into whether applied interventions are effective at improving your
60.
by david_l_lin 6y ago
We do not sell your DNA and do not have future plans to do so, in fact we don't currently store your personal genome information, and would inform you if this were to change. We will ask for consent before doing any analysis on your pe

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