daughart

15 ms·

91.
by daughart 11y ago
It's not clear to me what you are saying. Cas9/CRISPR unambiguously cuts the genome at a target site determined by the guide RNA sequence. In the presence of a DNA oligo with partial complementarity to the cut site, the DNA repair
92.
by daughart 11y ago
It will take millions of dollars of research to turn this basic bioengineering technique into an approved (safe and effective) human therapy. How do you motivate investors to fund this research without the safety net of a patent to protect
93.
by daughart 11y ago
Maybe I just didn't pick up on the buzz. (Just so people have context its a large lab divided between several physical rooms across two buildings. I was a relatively new grad student at the time.)
94.
by daughart 11y ago
Working in the Church lab (although not on CRISPR) at the time both papers came out, I recall everyone being surprised at Zhang's efforts even at the time of publication!
95.
by daughart 11y ago
Actually less idiotic than what Martin O'Malley said right afterwards, that we should never give up liberty for the promise of safety (paraphrased). Except that's exactly what a stop sign does... trade liberty to drive without sto
96.
by daughart 11y ago
I listen to Howard Stern on SiriusXM (there's a 1 month free trial for the smartphone app). It's my morning indulgence while sitting on the T drinking a coffee.
97.
by daughart 11y ago
Only at very high concentrations: Adverse neurological effects have been observed in rats and mice at doses of 100–200 mg Al/kg/day, while the USDA limit is 0.10–0.12 mg Al/kg/day for adult (25–30- and 70+-year-old) male
98.
by daughart 11y ago
To be fair, they're refusing to turn over scientists' communications, not the data itself. This is absolutely the right move, because scientists are people, not politicians. If any scientist has at any point said something that is
99.
by daughart 11y ago
Unfortunately I suspect this only reflects a small part of what it's like to be a woman. This doesn't cover any of the experiential disparities between men and women in the workplace, which I imagine are equally great and perhaps
100.
by daughart 11y ago
My understanding is that only the Edison machine uses finger prick amounts. However, it sounds like since these machines don't work they are using standard instruments. For these they take venous blood draws, just using a child-sized v
101.
by daughart 11y ago
The more data they have the more valuable they are to drug companies. The data doesn't help them provide you anything.
102.
by daughart 11y ago
Why not just sign into Game Center? It's a serious question. Once you enable Game Center it stops bothering you and as far as I can tell doesn't really do anything other than add you to leaderboards.
103.
by daughart 11y ago
This article in Fortune suggests Apple Watch is selling strongly in Best Buy stores: http://fortune.com/2015/08/25/best-buy-apple/
104.
Melies' film “A Trip to the Moon” being encoded into DNA(dailynews.com)
2 points by daughart 11y ago|0 comments
105.
by daughart 11y ago
If the embryos were not viable, can you really call them humans? In my opinion they're really not more human than a cell culture of human cells. By "in humans" I meant using cas9 in vivo to edit the genome of a living human p
106.
by daughart 11y ago
It should have been clear from the article that they haven't used this technique in humans yet. What other context is needed? They can easily do these things in cell lines and mice.
107.
by daughart 11y ago
I think it's just a metal heat sink, no liquid?
108.
by daughart 11y ago
In physics, there is a mathematical foundation upon which to build theory. In biology there is no theory. There's no way to design drugs based on an equation or a back-of-the-napkin doodle. There are no examples of therapeutics breakth
109.
by daughart 11y ago
> Cures don't make profit, treatments do. This shows that you don't understand the market well. "Harvoni, made by Gilead Sciences, has cure rates of between 94 and 99 per cent. It is the successor to Gilead’s Sovaldi, whic
110.
by daughart 11y ago
It seems really doubtful a startup would have two breakthrough drugs in different categories. I wouldn't answer an email with this information either. Plus the light conspiracy talk about pharma companies wanting a treatment not a cure
111.
by daughart 11y ago
A hallmark of "real ADD" is that tolerance typically doesn't build. Once you are at an appropriate dose you can stay there. The treatment is supposed to reduce inattentiveness and improve focus. If abused or used recreational
112.
by daughart 12y ago
Just kill the app afterwards. "This meta info of the media played is only removed after you forcefully close the browser." And no worries about the saved screenshot either.
113.
by daughart 12y ago
Just dedicate a browser other than your normal one to porn. Eg if you use Safari use the Opera browser for porn.
114.
by daughart 12y ago
Interesting article, I'm very new to the field but I have an exciting application for GIS--I'm a biologist at Harvard and we have a new method to generate biological measurements at atomic scale inside biological specimens, and I
115.
by daughart 12y ago
I am very interested in this area, if anyone is knowledgeable about it I would love to get in contact and learn more. What is the landscape for bio-data companies? Any thoughts on business plans, exit plans? It seems obvious to me that area
116.
by daughart 12y ago
Unfortunately, not really. You might know it better as Obamacare, though. It created health insurance exchanges that are subsidized for low income people and reformed other aspects of medical reimbursement and regulations governing health i
117.
by daughart 12y ago
The morons part was just me being facetious. Since I edited my comment I went from -3 to 0, so apparently people agree. I don't know why asking for a counter-argument would get me banned, or how you know anything about being banned fro
118.
by daughart 12y ago
I think perspective matters here somewhat. If you're scooped as an established scientist, it is a kind of validation of the importance of your work. If you're scooped as a graduate student or post-doc, it can be a disheartening lo
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by daughart 12y ago
Interesting, but I'm more concerned about prioritization of Skype over FaceTime because Microsoft pays Comcast more than Apple.
120.
by daughart 12y ago
There was a study a while back that suggested FODMAPs, not gluten, was a prime candidate for this type of symptom. "Fodmaps is an acronym for fermentable oligosaccharides, disaccharides, monosaccharides and polyols, sugars that draw wa

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