cysteinechapel

4 ms·

1. 1.▲
   by cysteinechapel 1y ago

   To push back a little, isn't there causality inherently in these sequence-to-function models, in the sense that causality must proceed in the direction of genetics -> predicted molecular function? And the genetic contribution to phe
2. 2.▲
   by cysteinechapel 1y ago

   There are existing frameworks for integrating functional and statistical fine mapping methods (e.g. polyfun + susie/finemap). They use annotation overlaps like epigenetic or conservation tracks but can be extended to variant effect pre
3. 3.▲
   by cysteinechapel 1y ago

   Such an advantage that is rare and across such long time scales would be so small on average that it would be effectively neutral. Natural selection can only really act on fitness advantages greater than on the order of the inverse of effec
4. 4.▲
   by cysteinechapel 1y ago

   Plenty of simple models in biology that don't model the underlying details provide profoundly generalizable insights across scales. The percolation threshold model explains phase transition behavior from the savanna-forest transition t
5. 5.▲
   by cysteinechapel 1y ago

   Scales can also decouple from each other. Complex trait genetic variation at the whole genome level acts predominantly in an additive fashion even though individual genes and variants have clearly non-linear epistatic interactions.