couteiral

3 ms·

1. 1.▲
   by couteiral 5y ago

   Yes: they predict structures using MSAs, without alignments to known protein structures in a majority of the cases.
2. 2.▲
   by couteiral 5y ago

   Just in case there is a confusion: there is a difference between available sequences (~300 million in standard protein sequence repositories) and structures (~170k structures in the PDB, perhaps about ~120k that are structurally non-red
3. 3.▲
   by couteiral 5y ago

   I respectfully disagree. AlphaFold 2 demonstrated almost perfect performance for a multitude of proteins for which no meaningful templates were available -- hence, it was not doing homology modelling as it is generally understood, but ab in
4. 4.▲
   by couteiral 5y ago

   There is a growing trend to include Docker (or Singularity, which is more compatible with HPC architectures common in bioinformatics) images alongside codes. In particular, AlphaFold 2 does provide a Dockerfile, and they even include a Pyth
5. 5.▲
   AlphaFold 2 is here: what’s behind the structure prediction miracle(blopig.com)

   241 points by couteiral 5y ago|93 comments