colingauvin

4 ms·

1.
by colingauvin 2mo ago
We don't have to put up with this. We simply choose to. But our laws could be whatever we want them to be.
2.
by colingauvin 2mo ago
The FDA does not let you put something in humans without a significant amount of data, full stop. And even for a small trial, the cost of the GLP tox and the GMP manufacturing is in the millions. Of course it is nowhere near as complex as p
3.
by colingauvin 2mo ago
>Across a 20-benchmark suite spanning reasoning, math, coding, instruction following, vision, and agentic tool use, Ternary Bonsai 2 27B achieves an aggregate score of 83.9, retaining 98.2% of Qwen3.8 27B’s performance of 85.4. The model
4.
PrismML Launches Bonsai 2 27B, Its Most Capable Model Yet(prismml.com)
3 points by colingauvin 2mo ago|1 comments
5.
by colingauvin 2mo ago
I have been trying to build an assistant for a year+ at this point. I have still yet to come up with a model, harness, and set of instructions that get it to reliably not contact me just to regurgitate things I already know like text messag
6.
Perhaps I Got Lucky Never Learning Math(humanparadox.org)
4 points by colingauvin 2mo ago|1 comments
7.
by colingauvin 2mo ago
INDs and phase 1s are expensive and not trivial in any sense.
8.
by colingauvin 2mo ago
Very much regret not having been able to attend last night, but kids came down with the return to school virus. Big fan of this law and also putting MT more on the map for biotech.
9.
by colingauvin 2mo ago
If it works reliably, sure? But like, it's not something I'd pay for.
10.
by colingauvin 2mo ago
I'm probably about 90%ile income for my household but live in a HCoL area and have two children in daycare. I rent, don't own, and I have enough that I can buy a coffee without thinking, but will be sending my kids to public schoo
11.
by colingauvin 2mo ago
Because I used a semicolon? Very much not an AI...I think
12.
by colingauvin 2mo ago
Ok this cracked me up; thank you.
13.
by colingauvin 2mo ago
I used to laugh at those "this software may not be used in the development of nuclear weapons" lines.
14.
by colingauvin 2mo ago
But they aren't really competitive for cost in that size class.
15.
by colingauvin 2mo ago
It's not particularly good value if you are just comparing $ with no other context. Point is just that it's accessible and so now Anthropic and OpenAI need to make both a performance proposition and a value proposition.
16.
by colingauvin 2mo ago
Not to discredit your opinion here, but will just point out I am also a PhD biochemist who has worked on viruses, so hopefully our credentials cancel. :)
17.
by colingauvin 2mo ago
OpenAI just paused new subscriptions to their $200 plan. They are in a rock and a hard place. Obviously the Astras and Fables of the world are exponentially more expensive, but for...less than exponential returns. The question is whether th
18.
by colingauvin 2mo ago
I am for more sick of reading people complain about it than I am seeing it. The page is a table. It was fine.
19.
by colingauvin 2mo ago
I would never advocate they not be allowed to say it. But I also am sick of hearing wildly unrealistic takes.
20.
by colingauvin 2mo ago
This number gets cited a lot but it's actually the excess mortality of post-European contact, and it's not content wide, it's specific to Mexico. It also includes climate change, famine, war, relocation, etc.
21.
by colingauvin 2mo ago
Arguably yes. I would wager no one killed by an asteroid in the history of people killed by asteroids realized what was happening before they died.
22.
by colingauvin 2mo ago
Most people do not understand how easy it would be to make anthrax. Technology is not the reason it basically is never done or deployed. AI cannot meaningfully move this needle. Let's look at it in an inverse way. Making a single drug
23.
by colingauvin 2mo ago
Oh my God THANK YOU. I do not have the words how tired I am of hearing tech people and economists talk about biology.
24.
by colingauvin 2mo ago
yawn Can we just think through the logistics of AI taking over the world? Like, we won't notice it using all our GPUs? Like it somehow would have enough context to take over the world? lol.
25.
by colingauvin 2mo ago
Yes but you will lose 120 FPS/VRR. So for high end TVs not really ideal.
26.
by colingauvin 2mo ago
I'm not trying to read your comment as whataboutism, but it did get me wondering: From a moral or ethical standpoint, if there is a gradient route from "very immoral to moral", but it involves first going from "very immo
27.
by colingauvin 2mo ago
Early Fairphones were not necessarily designed for repairability. That is a principle that has emerged significantly in the last few iterations. The FP4 was the first that was really designed and marketed as fully modular from what I rememb
28.
by colingauvin 2mo ago
Fascinating. I work in this space sort of, there's still a ton I don't understand. What is the legal space like? Are you at risk of being shut down on a dime if the FDA decides Lilly can meet demand? Are you able to compound small
29.
by colingauvin 2mo ago
Since you posted this the Asus GX10 went from $4000 to $6000. https://eshop.asus.com/us/ascent-gx10.html
30.
by colingauvin 2mo ago
GLM 5.3 Flash? Qwen 3.8 Flash Next? I believe those both are as good as the best Gemini, competitive with Terra.

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