cjbgkagh

10 ms·

211.
by cjbgkagh 7mo ago
I warned you specifically that this Iran war was coming and would not end up in Israel’s favor. As I stated “the Iran war is already unpopular and it hasn’t even started yet.” I understand that it is not yet over. Iran and its proxies can s
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by cjbgkagh 7mo ago
I think it’s less about the money and more about a formal declaration who won the conflict. The loser sues for peace / pays reparations.
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by cjbgkagh 7mo ago
If it holds they’ll be a regional hegemon instead of Israel, which is why Israel will not let it hold. They put everything on the line and they’re not going to give up now.
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by cjbgkagh 7mo ago
Yeah, the US overplayed its hand and is in a weak bargaining position and will likely have to accept less than what it could have had. Now with TACO Tuesday who could take his maximalist carpet nuking threats seriously anymore. I hope to be
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by cjbgkagh 7mo ago
I think this 10 point plan drops the need for US to pay reparations instead relying on transit fees which will be split with Oman. Missiles are still flying so it’s hard to say who has really agreed to what. I’ve heard rumors that Iran has
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by cjbgkagh 7mo ago
You’re not understanding the point of the hypothetical, it was to illustrate a scenario in that most people would consider evidential and point out that by definition the opposite outcome must also be evidential even if that outcome was far
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by cjbgkagh 7mo ago
Because I started at such low dose 0.025mg and ramped slowly I didn’t expect to see much of an effect until I got to more normal doses so I was unusually patient with it. Additionally extended water fasting (>5 days) was the only thing h
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by cjbgkagh 7mo ago
’fundamentalist’ has religious connotations which I did not intend, I meant deduction from first principles not foundational orthodoxy. My expression was there was tension not completely discrete factions, there is clearly some empiricism u
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by cjbgkagh 7mo ago
Thanks for the feedback, I’m noticing that ‘fundamentalism’ didn’t translate properly and I should have referred to first principles and mechanisms of action. I need better words for these and I will try to find them. As a fun aside, consid
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by cjbgkagh 7mo ago
If a lot of people take the mediation and die is that evidence that the medication is unsafe? If they live is that evidence that the medication is safe? Either both are true or neither is true. The relative weight of evidence is dependent o
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by cjbgkagh 7mo ago
I’ve not only visited many doctors personally I was also part of a team working on a medical diagnostic instrument, the result of the instrument was a probability distribution function and it was impossible to explain this to the doctors wh
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by cjbgkagh 7mo ago
Unless you’ve had ME/CFS you cannot understand how bad it is, I’ve had it and I still have a hard time comprehending how bad it was, I am occasionally reminded and it’s easy to forget. While it won’t kill you it’ll destroy your life un
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by cjbgkagh 7mo ago
The US is a rather dysfunctional country along many axis and an inability to stop imports is one of them. The difference between drugs and peptides is that by weight peptides are much more valuable. 1kg of cocaine is $28K, fentanyl is $150K
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by cjbgkagh 7mo ago
High-Performance Liquid Chromatography so purity and concentration. Back when I started few people were doing this and it was more of a risk, I was buying from research peptide vendors who had their own testing practices, but now a huge num
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by cjbgkagh 7mo ago
The vast majority of drug candidates don’t make it to the trial stage. Much of the research has to be defensible prior to the trial and what makes them defensible is having a mechanism for action. Of course once a drug is being used off lab
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by cjbgkagh 7mo ago
There are now a number of very definitive tests, most related to immune system profiling. Prof. Ron Davis has some good research and has shown that plasma from someone with ME/CFS when combined with normal red blood cells will greatly
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by cjbgkagh 7mo ago
Yes, sensitivity at over 10x normal, so I just took 10x less. I’m taking a more normal dose now after 4 years and I believe I have become desensitized as my body normalized. Other seemingly unrelated aspects also normalized such as thyroid,
228.
by cjbgkagh 7mo ago
Doctors have been maligning ME/CFS as psychosamatic for decades and generally still do despite a large amount of modern evidence to the contrary. If you have it it’s clearly not, you can get good and bad days that are clearly not depen
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by cjbgkagh 7mo ago
I have tried everything on just about every list of possible treatments, having been in the fortunate position to have made enough money that I can try things full time and being able to bypass doctors for access to medicine and being able
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by cjbgkagh 7mo ago
I don’t know the mechanism, I think ME/CFS is an autoimmune condition and semiglutide appears to help with autoimmune conditions in general. That was my reason for trying it. The improvements snuck up on me after many months as I notic
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by cjbgkagh 7mo ago
Placebos would work with anything with a plausible story, since I’ve tried many hundreds of things and only a handful worked I’m highly confident that it’s not a placebo. People with ME/CFS are used to trying things and have them not w
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by cjbgkagh 7mo ago
That makes sense, I don't like that the bottles are unlabelled so the first thing I have to do is label them. The box is labelled and this seems to be standard practice. Semaglutide is falling out of favour so I guess they're sub
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by cjbgkagh 7mo ago
I used to buy from Peptide Sciences so I was certainly paying a premium for reputation at $20/mg. I think Semaglutide is now at a bit of a premium due to it falling out of favour and most people switching to Triz and Reta. I only take
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by cjbgkagh 7mo ago
With most of these you can really tell if they work or not and there is a pretty predicable dose dependent reaction profile. With slow meds like semaglutide you'd maybe not notice it in the first week but you will by week 3. I had mine
235.
by cjbgkagh 7mo ago
I bought Semaglutide at 50c/mg and had it tested, it's the real deal. What's the normal price, $100/mg? My gf is in medicine so she had a friend test it through their work.
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by cjbgkagh 7mo ago
Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fu
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by cjbgkagh 7mo ago
They thought after V8 the performance was going keep improving and reach native speeds, they didn’t understand that the major performance wins were all upfront and it would hit a wall.
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by cjbgkagh 7mo ago
Often kind of person who makes such mistakes is the kind of person unable to learn from them. The post by Sinofsky is exactly as I imagined it would be.
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by cjbgkagh 7mo ago
He’s still around as a part time advisor, he has to officially step back or no one would take Satya seriously, but on important stuff like AI he is a bit more active.
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by cjbgkagh 7mo ago
> With all due respect, if the idea is good, then it will happen. Not sure if that's survivorship bias or post-facto rationalization. I guess the 'it will happen' implies eventually and since we cannot wait for all time th

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